View source for Adenosine A2A receptor

<StructureSection load='' size='350' side='right' scene='54/540144/Cv/1' caption='Human A2AR (mutant) complex with adenosine [[2ydo]]'>

== Function ==

'''Adenosine A2A receptor''' (A2AR) is one of the G protein-coupled receptors.  The protein uses adenosine as the preferred endogenous agonist and is involved in increasing intracellular cAMP levels.<ref>PMID:21593763</ref>

== Disease ==

A2AR antagonists are being tested in the treatment of Alzheimer's Disease.

== Relevance ==

A2AR is responsible for regulating myocardial blood flow.  It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep.  For details see [[G protein-coupled receptor]].  A2AR is blocked by <scene name='54/540144/5mzp_caffeine/1'>caffeine</scene> producing the arousal effect.<ref>PMID:21734299</ref>  For details see [[Caffeine]]. 

See also:
* [[G protein-coupled receptor]]
*[[Receptor]]
*[[Transmembrane (cell surface) receptors]]

== Structural highlights ==

Like other G proteins, <scene name='54/540144/Cv/5'>A2AR has 7 transmembrane helices</scene>. 
*<scene name='54/540144/Cv/8'>A2AR has a ligand-binding cavity</scene>. 
*<scene name='54/540144/Cv/7'>Adenosine binding site</scene>.

== 3D Structures of adenosine A2A receptor ==
[[Adenosine A2A receptor 3D structures]]

</StructureSection>



== References ==
<references/>
[[Category:Topic Page]]