View source for Adhesin

<StructureSection load='' size='350' side='right' caption='Adhesin PsaA complex with tert-butyl formate and galactose (stick model) (PDB ID [[4f8p]])' scene='70/705684/Cv/1'>

== Function ==

'''Adhesins''' (Adh) are surface components of bacteria which facillitate adhesion to surfaces or other cells.  Adh are specific surface recognition protein and are regarded as virulence factors.<ref>PMID:11043979</ref>  '''FimH''' is the ''E. coli'' adhesin which is part of the type 1 pili of the bacteria.  The pili is composed of subunits '''FimF, FimG''' and '''FimD'''<ref>PMID:18369105</ref>.  The main Adhesins of the pathogen ''Mycoplasma genitalium'' are '''P110''' or '''Mgp-operon protein 3''' and '''P140'''<ref>PMID:30367053</ref>. See also [[Journal:Acta Cryst D:S2059798320008116|Novel structure of the N-terminal helical domain of BibA, a Group B Streptococcus immunogenic bacterial adhesin]].

For trimeric autotransporter adhesin see [[EibD]].

== Disease ==

Bacterial pathogens use adhesins as a major factor in adhesion-based virulence.  Adhesins serve as vaccine targets since they are essential to infection<ref>PMID:10341176</ref>.

== Structural highlights == 

<scene name='70/705684/Cv/4'>Adhesin PsaA complex with galactose, acetate and tert-butyl formate</scene> (PDB ID [[4f8p]])<ref>PMID:23277582</ref>
*<scene name='70/705684/Cv/3'>Galactose binding site</scene>. Water molecules are shown as red spheres.
*<scene name='70/705684/Cv/5'>Tert-butyl formate/Acetate binding site</scene>.

== 3D Structures of adhesin ==
[[Adhesin 3D structures]]

</StructureSection>


== References ==
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