View source for Amino acid oxidase

<StructureSection load='2jb1' size='400' side='right' scene='48/486454/Cv/1' caption='L-amino acid oxidase dimer containing FAD complex with alanine, [[2jb1]]'>
__TOC__

== Function ==

'''Amino acid oxidase''' catalyzes the oxidation of amino acids to the keto acid producing ammonia and hydrogen peroxide.  These enzymes oxidize D-amino acids (DAO) and L-amino acids (LAO).  The LAO oxidation products are 2-oxo acid, ammonia and hydrogen peroxide.  LAO is widely found in snake venom.<ref>PMID:12175601</ref>  DAOs oxidize neutral and basic D-amino acids.<ref>PMID:17396222</ref>  
*'''L-amino acid oxidase/monooxigenase''' catalyzes both the oxidative deamination and oxidative decarboxylation of the alpha group of L-Lys producing keto acid and amide<ref>PMID:29511608</ref>.

== Relevance ==

Some DAOs are used in cancer therapy as inducers of oxidative stress and apoptosis.  DAO and LAO use FAD as a cofactor. 

== Structural highlights ==

LAO structure contains 3 domains: <scene name='48/486454/Cv/5'>FAD-binding, substrate-binding and helical</scene> domains.  <scene name='48/486454/Cv/6'>Active site</scene> of L-amino acid oxidase ([[2jb1]]).<ref>PMID:17234209</ref> Water molecules are shown as red spheres.

==3D structures of amino acid oxidase==
[[Amino acid oxidase 3D structures]]

</StructureSection>

== References ==
<references/>
[[Category:Topic Page]]