View source for Atlastin

<StructureSection load='4ido' size='350' side='right' caption='Structure of human atlastin cytoplasmic domain complex with GDP and AlF4 (PDB code [[4ido]]).' scene='59/590828/Cv/7'>

== Function ==

'''Atlastin''' (ATN) is a GTPase and a Golgi body transmembrane protein.  ATN was shown to be required in membrane fusion and ER formation in ''Drosophila melanogaster''.<ref name="Ad">PMID:23334294</ref>

== Disease ==

Defects in the ATN gene are a cause of the degenerative spinal cord disorder spastic paraplegia type 3 and of hereditary sensory neuropathy type 1D.  Mutations in ATL-3 affect multiple ER-related pathways<ref>PMID:30666337</ref>.

== Structural highlights ==
*<scene name='59/590828/Cv/6'>GDP/AlF4 binding site</scene> from human atlastin (PDB code [[4ido]]).<ref name="Ad">PMID:23334294</ref> Water molecules shown as red spheres.

==3D structures of atlastin==
[[Atlastin 3D structures]]

</StructureSection>

== References ==
<references/>
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