View source for BRCA

<StructureSection load='' size='450' side='right' caption='Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code [[3coj]]) ' scene='75/750267/Cv/4' pspeed='8'>

== Function ==
'''BRCA1''' and '''BRCA2''' or '''breast cancer type 1 susceptibility protein''' are tumor suppressors which help repair damaged DNA.  For more details see:
*[[RING Finger Domain of BRCA1 and BARD1 Heterodimer]].
*[[Mutations in BRCA1/BARD1 RING-domain heterodimer]].
*[[Mutations in Brca1 BRCT Domains]].

== Disease ==
Mutations in BRAC1 and BRAC2 are associated with increased risk of breast cancer, ovarian cancer and to a lesser extent with other cancers<ref>PMID:20301425</ref>.

== Structural highlights ==
The <scene name='75/750267/Cv/5'>phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains</scene>.  These domains contain most of the mutations seen in BRCA1<ref>PMID:18452305</ref>. <scene name='75/750267/Cv/6'>Phosphoserine binding</scene>. 

==3D structures of BRCA==
[[BRCA 3D structures]]

</StructureSection>

== References ==
<references/>
[[Category:Topic Page]]