View source for Band 3

==Band 3==
<StructureSection load='7rtm' size='340' side='right' caption='Rabbit Band 3 dimer PDB code [[7rtm]].' scene=''>
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==Function== 

'''Anion exchanger 1''' (AE1), also known as '''band 3''' or '''SLC4A1''' or '''Band 3 anion transport protein''' or '''anion exchange protein''' exchanges chloride and bicarbonate across the red blood cell membrane, assisting in removing carbon dioxide from tissues. It also anchors the membrane skeleton <ref>PMID:34669510</ref>. Band 3's name comes from its appearance as the third major band on SDS-PAGE of red blood cell membrane proteins <ref>PMID: 4326772</ref>. 

Its function has been studied for more than 150 years; even so, the first complete structure was not published until 2015 <ref>PMID: 26542571</ref>, and the first crystals grown without addition of an antibody were grown on the International Space Station <ref> PMID: 30118660</ref>.  

==Disease==

Mutations in AE1 can cause distal renal tubular acidosis<ref> PMID:15649129</ref>. 
== Structural highlights ==

Band 3 functions as a <scene name='96/962946/Dimer_inside_outside/1'>dimer</scene>.  Each monomer contains fourteen transmembrane segments, as well as an intracellular domain that plays a gating role and a small extracellular domain.

==3D structures of anion exchange protein==

[[Anion exchange protein 3D structures]]

== References ==
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</StructureSection>

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