View source for Carbamazepine

<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='10/1025400/Cv/3'>
Carbamazepine, sold under the brand name Tegretol among others, is an anticonvulsant medication used in the treatment of epilepsy and neuropathic pain.<ref name="a4">[https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8d409411-aa9f-4f3a-a52c-fbcb0c3ec053 "Tegretol - carbamazepine suspension Tegretol - carbamazepine tablet Tegretol XR- carbamazepine tablet, extended release".] DailyMed. 16 May 2022. Retrieved 3 January 2023.</ref><ref name="a1">[https://www.drugs.com/monograph/carbamazepine.html "Carbamazepine".] The American Society of Health-System Pharmacists. Archived from the original on 27 February 2015. Retrieved 28 March 2015.</ref> It is used as an adjunctive treatment in schizophrenia along with other medications and as a second-line agent in bipolar disorder.<ref name="a6">PMID:30091458</ref><ref name="a1">[https://www.drugs.com/monograph/carbamazepine.html "Carbamazepine".] The American Society of Health-System Pharmacists. Archived from the original on 27 February 2015. Retrieved 28 March 2015.</ref> Carbamazepine appears to work as well as phenytoin and valproate for focal and generalized seizures.<ref name="a7">PMID: 31318037</ref> It is not effective for absence or myoclonic seizures.<ref name="a1">[https://www.drugs.com/monograph/carbamazepine.html "Carbamazepine".] The American Society of Health-System Pharmacists. Archived from the original on 27 February 2015. Retrieved 28 March 2015.</ref> See also [https://en.wikipedia.org/wiki/Carbamazepine Carbamazepine].

Carbamazepine is a sodium channel blocker.<ref name="a36">PMID: 26801895</ref> It binds preferentially to voltage-gated sodium channels (Nav) in their inactive conformation, which prevents repetitive and sustained firing of an action potential.

<scene name='10/1025400/Cv/2'>Nav1.7 with Carbamazepine</scene> ([[8s9c]]).

<scene name='10/1025400/Cv/4'>Carbamazepine binding site</scene>.
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== References ==
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