View source for Ceftazidime

<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='10/1041498/Cv/1'>
Ceftazidime, sold under the brand name Fortaz among others, is a third-generation [[cephalosporin]] antibiotic useful for the treatment of a number of bacterial infections. Specifically it is used for joint infections, meningitis, pneumonia, sepsis, urinary tract infections, malignant otitis externa, Pseudomonas aeruginosa infection, and vibrio infection.<ref name="a1">[https://www.drugs.com/monograph/ceftazidime.html "Ceftazidime".] The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.</ref> See also [https://en.wikipedia.org/wiki/Ceftazidime Ceftazidime].

Third-generation cephalosporins differ from earlier generations in the presence of a C=N-OCH3 group in their chemical structure (cefuroxime & cefuzonam also bear this functional group but are only listed as class II). This group provides improved stability against certain [[beta-lactamase]] enzymes produced by Gram-negative bacteria. These bacterial enzymes rapidly destroy earlier-generation cephalosporins by breaking open the drug's beta-lactam chemical ring, leading to antibiotic resistance. Though initially active against these bacteria, with widespread use of third-generation cephalosporins, some Gram-negative bacteria that produce extended-spectrum beta-lactamases (ESBLs) are even able to inactivate the third-generation cephalosporins. Infections caused by ESBL-producing Gram-negative bacteria are of particular concern in hospitals and other healthcare facilities.<ref name="a19">PMID:24298468</ref>

<scene name='10/1041498/Cv/2'>Penicillin-binding protein PBP3 complexed with ceftazidime</scene> ([[3pbo]]).

<scene name='10/1041498/Cv/5'>Ceftazidime binding site</scene>. Water molecules are shown as red spheres.
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== References ==
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