View source for Cholesterol esterase

<StructureSection load='1llf' size='350' side='right' caption='Glycosylated cholesterol esterase dimer complex with bile acid (PDB entry [[1llf]])' scene='52/525136/Cv/1'>
== Function ==

'''Cholesterol esterase''' (ChoE) also named '''bile-salt activated lipase''' or '''sterol esterase''' catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides.<ref>PMID:11563913</ref> 

== Disease ==

Deficiency of this enzyme causes Wolman’s disease and cholesteryl ester storage disease.

== Structural highlights ==

ChoE <scene name='52/525136/Cv/9'>ligand-binding tunnel is ca. 30 A long</scene> ({{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}). ChoE has the <scene name='52/525136/Cv/10'>polar catalytic triad Ser-His-Glu</scene> at the opening and <scene name='52/525136/Cv/11'>hydrophobic residues lining the bottom cup</scene>.<ref>PMID:12499539</ref>

==3D structures of cholesterol esterase==
[[Cholesterol esterase 3D structures]]

</StructureSection>

== References ==
<references/>
[[Category:Topic Page]]