View source for Cullin

<StructureSection load='' size='340' side='right' caption='Human cullin-1 (cyan) complex with ring box protein 1 (green) and Zn+2 ion (grey) (PDB code [[1ldj]])' scene='70/706699/Cv/2'>
'''Cullins''' are hydrophobic scaffold proteins for E3 ubiquitin ligases.  They combine with ring box proteins (RBX) to form the CRL complex.<ref>PMID:15688063</ref>  The CRL complex is essential in targeting proteins to ubiquitin-mediated destruction.  Cullin-1 to 7 are part of the multi-subunit ubiquitin complex.  Conjugation of cullin to NEDD8 modulates the activation of the CRL.<br />
*'''Cullin-1''' is part of the SCF (Skp-cullin-F-box containing) complex which catalyzes the ubiquitination of proteins.<ref>PMID:11961546</ref><br />
*'''Cullin-2''' is part of the ECS (Elongin-cullin-SOCS-box) complex.<ref>PMID:25661653</ref><br />
*'''Cullin-3''' is part of the BTB-Cul3 complex.<ref>PMID:23349464</ref> <br />
*'''Cullin-4A and 4B''' regulate various processes like DNA repair, chromatin remodeling and mitotic cell cycle.<ref>PMID:22118460</ref><br />
*'''Cullin-5''' inhibits cellular proliferation.<ref>PMID:18805092</ref><br />
*'''Cullin-7''' is a core component of a complex which mediates ubiquitination of target proteins.<ref>PMID:17298945</ref><br />

<scene name='70/706699/Cv/7'>Human cullin-1 complex with ring box protein 1 and Zn+2 ions</scene>.

<scene name='70/706699/Cv/8'>1st Zn coordination site</scene>.

<scene name='70/706699/Cv/9'>2nd Zn coordination site</scene>.

<scene name='70/706699/Cv/10'>3rd Zn coordination site</scene>.(PDB code [[1ldj]])

== 3D Structures of cullin==
[[Cullin 3D structures]]

</StructureSection>

== References ==
<references/>
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