View source for Death-associated protein kinase

<StructureSection load='1jkl' size='350' side='right' caption='Structure of human death-associated protein kinase 1 catalytic domain complex with ATP analog (PDB entry [[1jkl]])' scene='51/517372/Cv/1'>
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== Function ==

'''Death-associated protein kinase''' (DAPK) is a multi-domain serine/threonine kinase which regulates cell death mechanisms and has tumor suppression functions.<ref>PMID:16756490</ref>  <br />
* '''DAPK1''' is a positive mediator of γ-interferon induced programmed cell death.  <br />
* '''DAPK2''' is a calcium/calmodulin dependent kinase involved in multiple cell signaling pathways which trigger cell survival.  <br />
* '''DAPK3''' or zipper-interacting protein kinase is involved in the regulation of apoptosis. <br />

== Relevance ==

DAPK expression is lost in many types of cancer.  DAPK1 expression is elevated in brains of Alzheimer Disease patients and in epilepsy patients.  DAPK1 inhibitors are tested as drugs for attenuating acute brain injury.

== Structural highlights ==

DAPK1 structure contains a small β sheet N-terminal lobe and a larger helix-rich C-terminal lobe.  <scene name='51/517372/Cv/3'>The ATP substrate is bound in a cleft between the two lobes</scene>. <ref>PMID:11573098</ref>

==3D structures of death-associated protein kinase==
[[Death-associated protein kinase 3D structures]]

</StructureSection>
 
== References ==
<references/>
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