View source for Elastase

<StructureSection load='1eai' size='350' side='right' caption='Pig elastase (cyan, green) complex with chymotrypsin/elastase isoinhibitor (magenta, yellow)  (PDB code [[1eai]]).' scene='41/411401/Cv/3'>

[[Elastase]] (ELA) is a chymotrypsin-like serine protease which breaks down proteins.  The ELAs are numbered according to their genes.  '''Panceatic ELA''' cleaves proteins at the carboxyl-terminal side of small neutral amino acids.  It cleaves Ala-Ala and Ala-Gly bonds.  <ref>PMID:12059069</ref>  For additional details see <br />
*[[Protease]]<br />
*[[Serine Proteases]].

== Relevance ==

'''ELA1''' in the pancreas correlates well with exocrine pancreatic functioning and is used as a function test for patients with pancreatitis.  '''ELA2''' (or PMN-ELA) is secreted by neutrophils during inflammation.

== Disease ==

Pulmonary emphysema is caused by the destruction of elastic fibre by elastase.  Mutations in ELA2 are linked to the genetic disorder cyclic hematopoeiesis.  Neutrophil elastase is involved in the blistering in bullose pemphigoid.

== Structural highlights ==

<scene name='41/411401/Cv/8'>Pig elastase</scene> (cyan, green) complex with <scene name='41/411401/Cv/9'>chymotrypsin/elastase isoinhibitor</scene> (magenta, yellow)  (PDB code [[1eai]]). ELA <scene name='41/411401/Cv/10'>catalytic triad is Ser-His-Asp</scene>.<ref>PMID:7922044</ref>

==3D structures of elastase==
[[Elastase 3D structures]]

</StructureSection>

== References ==
<references/>
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