View source for Enoyl-CoA hydratase

<StructureSection load='1mj3' size='350' side='right' caption='Structure of enoyl-CoA hydratase complex with hexadienoyl-CoA (PDB code [[1mj3]]).' scene='59/594523/Cv/1'>

== Function ==

'''Enoyl-CoA hydratase''' (ECH) (gene '''rpfF''') is part of the fatty acid metabolism ([[Beta oxidation]]). ECH hydrates the double bond between the second and third carbons in acyl-CoA.  
*'''ECH1''' or '''short-chain ECH''' is mitochondrial.  It processes enoyl-CoA thioesters from C4 to C16<ref>PMID:12467702</ref>. 
*'''ECH2''' hydrates enoyl-CoA to 3-hydroxyacyl-CoA in the oxidation of fatty acids pathway<ref>PMID:15051722</ref>. 
*'''Enoyl-CoA hydratase/isomerase''' catalyzes the hydration and hydrolysis of methylthioacryloyl-CoA in the last step of the methanethiol pathway of dimethyl-sulphoniopropionate catabolism<ref>PMID:23704947</ref>.

== Disease ==

ECH1 mutations cause combined respiratory chain deficiency resulting inn Leigh syndrome<ref>PMID:25393721</ref>.

== Structural highlights ==

<scene name='59/594523/Cv/2'>Rat ECH is homohexamer</scene>; <scene name='59/594523/Cv/3'>another view for homohexamer</scene>. ECH <scene name='59/594523/Cv/7'>active site binds the substrate analog hexadienoyl-CoA</scene>. <ref>PMID:12445775</ref>

==3D structures of enoyl-CoA hydratase==
[[Enoyl-CoA hydratase 3D structures]]

</StructureSection>

== References ==
<references/>

[[Category:Topic Page]]