View source for Filamin

<StructureSection load='2wa5' size='350' side='right' scene='' caption='Human Filamin B actin-binding domain complex with sulfate and carbonate (PDB code [[2wa5]]) '>

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== Function ==

* [[Filamin]] '''A (FLNA)''' has an actin-binding domain (ABD).  It crosslinks actin filaments and participates in anchoring of membrane proteins<ref>PMID:19773341</ref>.<br />
*  '''Filamin B (FLNB)''' is a human cytoplasmic protein which functions similarly to FLNA and guides proper skeletal development<ref>PMID:19505475</ref>.<br />
*  '''Filamin C (FLNC)''' is functionally similar and contains 3 domains: the N-terminal ABD, the C-terminal dimerization domain (DD) and a membrane glycoprotein-binding domain<ref>PMID:11336782</ref>.<br />
For more details on filamin C see [[Group:MUZIC:FilaminC]].

== Disease ==

Mutations in FLNA cause frontometaphyseal dysplasia, intestinal pseudo-obstruction, Melnick-Needles syndrome, otopalatodigital syndrome and periventricular heterotopia.  Mutations in FLNAB cause boomerang dysplasia<ref>PMID:25614868</ref>.

==3D structures of filamin==
[[Filamin 3D structures]]

</StructureSection>

==References==
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