View source for Hsp40

=='Hsp40s'==
<StructureSection load='2QLD' size='340' side='right' caption='Human Hsp40 Hdj1 (PDB code [[2qld]]).' scene=''>

These proteins ( J protein) and NEF cochaperones regulate the Hsp70 reaction cycle. The Hsp40 proteins constitute a large family with more than 40 members in
humans. All of them contain a J domain, which binds to the N-terminal ATPase domain of Hsp70 and the adjacent linker region. Canonical Hsp40s (members of classes I and II) function as chaperones independently and recruit Hsp70 to nonnative substrate proteins. Other Hsp40s (class III) are more diverse
and combine the J domain with a variety of functional modules. The interaction with Hsp70 strongly stimulates the hydrolysis of Hsp70-bound ATP to
ADP, resulting in stable substrate binding by Hsp70 in the closed conformation <ref>PMID:23746257</ref> to the rescue.


== References ==
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