View source for Human FKBP52

<StructureSection load='1q1c' size='350' side='right' scene='' caption='Human FKBP52 N-terminal complex with ethylene glycol and DMSO (PDB code [[1q1c]]) '>
[[Image:1q1c.png|left|200px]]

===Crystal structure of N-terminus of human FKBP52 ([[1q1c]])===
'''(see also [[FK506 binding protein]])'''

{{ABSTRACT_PUBMED_15159550}}
{{Clear}}
The 3D structures of several FKBP family members from various species are solved, most of them comprise 1-2 FK domains (''e.g.'' human FKBP52), while wFKBP73 (''e.g.'' [[3jym]]) has 3 FK domains which is characteristic to plants. A sequence-based structure comparison between each of the 3 FK domains of wFKBP73 ([[3jym]]) and the 2 FK domains of hFKBP52 ([[1q1c]]) was performed. All 3 FK domains of wFKBP73 adopt a typical FK fold exhibiting significant diversity when superimposed. They are arranged in a linear manner in space as observed in the 2 FK domains of hFKBP52. While the 2 FK domains of hFKBP52 are in the same orientation, the orientation between any 2 consecutive wFK73 domains is different than that between the two FK domains of hFKBP52. <scene name='3jym/Al/2'>Superposition</scene> of the <font color='blueviolet'><b>wFK73_1 (in blueviolet)</b></font> and <font color='cyan'><b>wFK73_2 (in cyan)</b></font> domains ([[3jym]]) on hFK52_1 (in yellow) and <font color='blue'><b>hFK52_2 (in blue)</b></font> revealed that while <font color='cyan'><b>wFK73_2</b></font> is perfectly aligned with <font color='blue'><b>hFK52_2</b></font>, N-terminal <font color='blueviolet'><b>wFK73_1</b></font> does not align with hFK52_1 (yellow). Similarly, <scene name='3jym/Al/3'>superposition</scene> of the <font color='cyan'><b>wFK73_2</b></font> and <font color='magenta'><b>wFK73_3 (in magenta)</b></font> domains on hFKBP52 revealed that while <font color='cyan'><b>wFK73_2</b></font> is perfectly aligned with hFK52_1 (in yellow), <font color='magenta'><b>wFK73_3</b></font> does not align with <font color='blue'><b>hFK52_2</b></font>. This unique arrangement of wFKBP73 causes that the α-helices of <scene name='3jym/Al/4'>wFKBP73 3 FK domains</scene> are exposed on the same surface, while the <scene name='3jym/Al/5'>2 α-helices of hFK52</scene> are presented on opposite surfaces.
==About this Structure==
1Q1C is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1C OCA]. 
</StructureSection>
==References==
<ref group="xtra">PMID:15159550</ref> <ref group="xtra">PMID:20306145</ref><references group="xtra"/>
[[Category:Topic Page]]
[[Category: Homo sapiens]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Ding, Y.]]
[[Category: Li, P.]]
[[Category: Lou, Z.]]
[[Category: Rao, Z.]]
[[Category: Shen, B.]]
[[Category: Shu, C.]]
[[Category: Wu, B.]]
[[Category: Nuclear protein]]
[[Category: Phosphorylation]]
[[Category: Rotamase]]
[[Category: Tpr repeat]]