View source for PI3K/AKT/mTOR signaling pathway

<StructureSection load='3hhm' size='350' side='right' scene='' caption='PI3K (grey) complex with NISH2 P85α and wortmannin (PDB code [[3hhm]]) '>
The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. [[PI3K]] activation phosphorylates and activates AKT, localizing it in the plasma membrane. Protein kinase B (PKB), also known as Akt, is the collective name of a set of three [[Serine/threonine protein kinase|serine/threonine-specific protein kinases]] that play key roles in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration. AKT can have a number of downstream effects such as activating CREB, inhibiting p27, localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating [[mTOR]], which can affect transcription of p70 or 4EBP1.

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== References ==
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