View source for Pannexin

<StructureSection load='7f8o' size='340' side='right' caption='Human pannexin 1 complex with lipid (PDB ID (7f8o)' scene='91/916893/Cv/2'>

== Function ==

'''Pannexin''' (PNX) is a family of single membrane channel-forming glycoprotein.  The family is comprised of 3 members.  PNX1 is expressed in mammalian tissue and plays a role in releasing signals for apoptotic cell clearance. In addition, PNX1 plays a role in propagation of calcium waves, regulation of vascular tone, mucociliary lung clearance, taste-bud function<ref>PMID:22305965</ref>.  PNX1 mediates release of ATP which acts as a signal recruiting macrophages to apoptotic cells.  PNX1 activation requires cleavage of its C-terminal tail by caspase<ref>PMID:22311983</ref>. 

== Relevance ==

PNX1 acts like a tumor suppressor in glioma and is involved in  melanoma, epilepsy, glaucoma, hypertension. Alzheimer, diabetes and other diseases<ref>PMID:25008946</ref>. 

== Structural highlights ==

The 3D structure of human <scene name='91/916893/Cv/3'>PNX1 shows the pore to constitute 7 subunits</scene>. The C-terminal of PNX1 is cleaved by caspase to produce an active PNX1. The pore transmembrane domains are occupied by <scene name='91/916893/Cv/5'>lipid molecules which interact predominantly with hydrophobic residues</scene><ref>PMID:35133866</ref>. 


==3D structures of pannexin==

[[Pannexin 3D structures]]

</StructureSection>
== References ==
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