View source for Phospholamban

<StructureSection load='4y3u' size='340' side='right' caption='Dog phospholamban (green and pink) complex with calcium pump (grey) and K+ ion (purple) (PDB code [[4y3u]])' scene=''>
== Function ==

'''Phospholamban''' (PLB) is a 52-amino acid membrane protein that regulates the Ca+2 pump in cardiac and skeletal muscle cells.  PLB functions as a homopentamer and is an inhibitor of Ca+2-ATPase in its unphosphorylated state.  When PLB is phosphorylated by protein kinase A, it dissociates from Ca+2-ATPase and its inhibitory function is lost resulting in increase of ATPase activity<ref>PMID:16317512</ref>.

== Disease ==

Mutations in PLB cause cardiomyopathy<ref>PMID:21167350</ref>.

== Relevance ==

PLB is a key protein in the cardiac diastolic function<ref>PMID:23907041</ref>.

</StructureSection>

== 3D Structures of phospholamban ==

[[Phospholamban 3D strucures]]

== References ==
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