View source for Phytase

<StructureSection load='3mmj' size='340' side='right' caption='Phytase in complex with inositol hexakisphosphate, phosphate, acetate, glycerol and Cl- ion (PDB code [[3mmj]])' scene='91/917455/Cv/1'>

== Function ==

'''Phytase''' or '''purple acid phosphatase''' or '''acidphosphatase''' (PHYT) catalyzes the hydrolysis of phytate (myo-inositol hexakisphosphate) to myo-inositol and inorganic phosphate <ref>PMID:9025298</ref>.  PHYT are a subclass of the histidine acid phosphatase<ref>PMID:9025298</ref>.  Phytate is the main phosphorus storage system in plant seeds. Phytate is indigestible by monogastric animals and humans<ref>PMID:32271147</ref>.

== Relevance ==

PHYT is found in plant material and is used to increase the nutritional quality of grains, legumes, seeds and corn. PHYT is used as a dietary supplement in broiler nutrition<ref>PMID:31610823</ref>. Studies show that supplementing PHYT can reduce the need for calcium phosphate and increase digestive health.

== Structural highlights ==

The 3D structure of <scene name='91/917455/Cv/6'>the complex between phytase and myo-inositol hexakisphosphate</scene> shows the extensive contacts of the phosphoryl groups of the substrate binding in the <scene name='91/917455/Cv/8'>highly basic binding pocket</scene><ref>PMID:22139834</ref>. Positively charged residues are colored in magenta; water molecules are shown as red spheres.   

==3D structures of phytase==
[[Phytase 3D structures]]

</StructureSection>
== References ==
<references/>

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