View source for Platelet glycoprotein

<StructureSection load='' size='350' side='right' scene='1m10/Surface/2' caption='Platelet-receptor glycoprotein Ib alpha (blue) involved in Willebrand disease bound to the von Willebrand Factor A1 Domain (green surface), ([[1m10]])' > 

{{Clear}}
===Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain===

{{ABSTRACT_PUBMED_12183630}}
*'''Platelet glycoprotein Ib alpha''' has a role in the adhesion and migration of leukocytes on vascular thrombus<ref>PMID:10899906</ref>.
*'''Platelet glycoprotein 4''' or '''CD36''' functions as a receptor for thrombospondin and collagen <ref>PMID:2665870</ref>.
*'''Platelet glycoprotein 6''' ha a role in collagen-induced platelet activation<ref>PMID:15381385</ref>.

==Disease==
Known disease associated with this structure: von Willebrand disease, autosomal dominant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=193400 193400]], von Willebrand disease, autosomal recessive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=193400 193400]], Bernard-Soulier syndrome, benign autosomal dominant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606672 606672]], Bernard-Soulier syndrome, type A OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606672 606672]], von Willebrand disease, platelet-type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606672 606672]], Nonarteritic anterior ischemic optic neuropathy, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606672 606672]]

==About this Structure==
{{Button ColorLeucine}} <scene name='1m10/Surface/2'>Initial scene</scene>

[[1m10]] is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M10 OCA]. 

</StructureSection>
==3D structures of platelet glycoprotein==

[[platelet glycoprotein 3D structures]]


==Reference==
<ref group="xtra">PMID:12183630</ref><references group="xtra"/>
<references/>
==See Also==
*[[Leucine-rich repeat]]
*[[Variable lymphocyte receptor]]
*[[Lamprey Variable Lymphocyte Receptor]]
*[[Diseases]]
[[Category:Topic Page]]
[[Category: Homo sapiens]]
[[Category: Groot, P G.de.]]
[[Category: Gros, P.]]
[[Category: Huizinga, E G.]]
[[Category: Romijn, R A.P.]]
[[Category: Schiphorst, M E.]]
[[Category: Sixma, J J.]]
[[Category: Tsuji, S.]]
[[Category: Dinucleotide binding fold]]
[[Category: Hemostasis]]
[[Category: Leucine-rich repeat]]