View source for Profilin

<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (grey),  VASP protein poly-Pro peptide (olive), ATP and Ca+2 ion (PDB code [[2pbd]])' scene=''>
== Function ==
'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin.  PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>.  PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers.  '''PFN-I''' is expressed in most tissues while '''PFN-II''' is expressed in brain and kidney.  PFN was found in all eukaryotes.

== Disease ==

PFN from birch, peanut and other plants is a major allergen<ref>PMID:25123397</ref>.

== 3D Structures of profilin ==
[[Profilin 3D Structures]]

</StructureSection>

== References ==
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