View source for Response regulator PLED in complex with C-di-GMP

<StructureSection load='1w25' size='400' side='right' scene='1w25/Chain_a/3' caption="Response regulator PleD complex with GMP, [[1w25]]">

[[Image:1w25_small.png|left]]
 
===RESPONSE REGULATOR PLED IN COMPLEX WITH C-DI-GMP===
<scene name='1w25/Chain_a/4'>Chain A</scene>

Phosphorylation site: <scene name='1w25/Acidic_pocket/1'>acidic pocket with Mg++ bound</scene>

Substrate binding site: <scene name='1w25/Active_site/2'>view1</scene>

&nbsp;&nbsp;&nbsp;  with c-di-GMP bound <scene name='1w25/Active_site/3'>view2</scene> <scene name='1w25/Active_site/5'>view3</scene> 

&nbsp;&nbsp;&nbsp; Note that the ligand is cross-linking to another substrate binding site <br>
&nbsp;&nbsp;&nbsp; (belonging to an adjacent dimer, not shown).

----

{{ABSTRACT_PUBMED_15569936}}

==About this Structure==
1W25 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W25 OCA].

Also see [[C-di-GMP_signaling#PleD]].
</StructureSection>

==Primary Reference==
Structural basis of activity and allosteric control of diguanylate cyclase., Chan C, Paul R, Samoray D, Amiot NC, Giese B, Jenal U, Schirmer T, Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17084-9. Epub 2004 Nov 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15569936 15569936]
==Further References==
Activated PleD structure [[2v0n]]:
<ref group="xtra">PMID:17697997</ref> <ref group="xtra">PMID:15075296</ref>  <ref group="xtra">PMID:17640875</ref>
<references group="xtra"/>

[[Category: Caulobacter vibrioides]]
[[Category: Single protein]]
[[Category: Chan, C.]]
[[Category: Jenal, U.]]
[[Category: Schirmer, T.]]
[[Category: Allosteric product inhibition]]
[[Category: Cyclic dinucleotide]]
[[Category: Cyclic-digmp]]
[[Category: Cyclic-di-GMP]]
[[Category: C-di-GMP]]
[[Category: Diguanylate cyclase]]
[[Category: Ggdef domain]]
[[Category: Phosphorylation]]
[[Category: Response regulator]]
[[Category: Signaling protein]]
[[Category: Two-component system]]
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Created by [[User:Tilman Schirmer|Tilman Schirmer]].