View source for Talk:Keratins

==  Ideas for improvement ==

This "figure-review" was written by Allycen Lindsay as part of an assignment for a Biochemistry course at Westfield State University, and posted by the instructor with permission.


#         '''My favorite figure''': Figure: “coiled-coil structure”. The figure shows the binding of the two subunits Keratin 5 and Keratin 14 and the specific residues Ser332-Gly421 of K14 and Thr382-Gly476 of K5 and the PDB ID is 3tnu. The name of the green link is script /wiki/scripts/55/559109/Cysteines/1.spt and the actual script is  https://proteopedia.org/wiki/scripts/55/559109/Cysteines/1.spt. The primary citation[1] is from 2012. Also available is a paper[2] that highlights the structure and function of keratins in more depth.
#         '''This is my suggestion for a figure legend''': Crystal structure of 2B helical domain of coiled-coil dimer of type 1  Keratin K14 and type II Keratin K5 showing the tightly bonded subunits. Chain A is green and Chain B is blue.
#         '''What I like about the figure''': It gives a representation of just how tightly bonded the two subunits are. The figure also gives you an option to locate different residues on the structure which helps in trying to understand what is going on. 
#         '''Corresponding figure in the primary citation''': Figure 1b [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864793/figure/F1/?report=objectonly] . In the figure, it shows how the structure of the 2B domain of K5-K14 is in parallel and bonded. It also shows the length of the structure as well as which α-helices is K14 and which is K5. The figure also shows the N and C terminus of the structure.
#         '''How I think the figure could be improved''': I think it would be really nice for the figure to have a label indicating which α-helices is K14 and which is K5 not just saying chain a or b. I also wish that the structure had a measurement indicating how long it was at the bottom. Once these elements are added, the figure legend would be updated so it could better explain the figure. 

 

References

# Lee C-H, Kim M-S, Chung BM, Leahy DJ, Coulombe PA. Structural basis for heteromeric assembly and perinuclear organization of keratin filaments. Nature Structural & Molecular Biology. 2012;19(7):707-715. doi:10.1038/nsmb.2330. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864793/

# McKittrick J, Chen P, Bodde SG, Yang W, Novitskaya EE, Meyers MA. The structure, functions, and mechanical properties of keratin. Jom. 2012;64(4):449-468,444-445. http://meyersgroup.ucsd.edu/papers/journals/Meyers%20354.pdf

--[[User:Karsten Theis|Karsten Theis]] 18:57, 10 December 2018 (UTC)