View source for Thiol:disulfide interchange protein

<StructureSection load='' size='340' side='right' caption='E. coli DsbC complex with MES (PDB code [[1eej]])' scene='70/705687/Cv/1'>
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== Function ==
'''Thiol:disulfide interchange protein''' is a prokaryotic disulfide bond isomerase.  <br />
*'''DsbA''' see [[Protein disulfide oxidoreductase]]<br />
*'''DsbC''' acts as a proofreader and breaks the incorrectly formed disulfide bonds.  DsbC is activated by the N terminal domain of DsbD<ref>PMID:9352906</ref>.<br />
*'''DsbD''' transfers electrons from the cytoplasmic thioredoxin to the periplasm thus maintaining the active site of DsbC, DsbE and DsbG in a reduced state<ref>PMID:10712691</ref>.<br />  
*'''DsbE''' catalyzes the reductive step in the assembly of periplasmic c-type cytochrome<ref>PMID:14597624</ref>.  <br />
*'''DsbG''' provides reducing equivalents to rescue oxidatively-damaged secreted proteins<ref>PMID:9654144</ref>.

== Structural highlights ==
DsbC active site contains a <scene name='70/705687/Cv/2'>CXXC motif</scene> which modulates the disulfide isomerization and protein folding in the bacterial periplasmic space<ref>PMID:11208797</ref><ref>PMID:11208797</ref>.
== 3D Structures of thiol:disulfide interchange protein ==
[[Thiol:disulfide interchange protein 3D structures]]

</StructureSection>

== References ==
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