View source for Ton

[[Image:TON.jpg|400px|right|thumb| The Ton System<ref name='Witty'> PMID: 12169623</ref>]]

==Structure==
The Ton system comprises of the triumvirate [[TonB]]/[[ExbB]]/[[ExbD]] inner membrane complex.

==Function==
The Ton proteins are involved in the uptake of vitamin B12 and chelated-iron into the cell<ref>PMID: 17347522</ref>, and the system as a whole is known to be an energy-transducing system.  Each of the three proteins involved have their separate role<ref name='Held'>PMID: 12193634</ref>.  For more information, see the respective pages for TonB, ExbB and ExbD.

The Ton system can be exploited by group B Colicins {see [[Colicin]] for more details) which include<ref name="Cascales">PMID: 17347522</ref><ref name='Davies'>PMID: 124727</ref>:
*[[Colicin 5]]
*[[Colicin 6]]
*[[Colicin 7]]
*[[Colicin 8]]
*[[Colicin 9]]
*[[Colicin 10]]
*[[Colicin Ia]]
*[[Colicin Ib]]
*[[Colicin B]]
*[[Colicin D]]
*[[Colicin M]]
*[[Colicin V]]
*[[Colicin Js]]
*[[Colicin Y]]

It is interesting to note that the name 'Ton' comes its resistance to the T1 phage<ref name='Davies'>PMID: 124727</ref>.

==Interaction of Ton proteins==
Like in the [[Tol]] complex, the Ton system proteins interact with each other<ref>PMID: 9811664</ref>:
# the transmembrane domain of TonB interacts with both ExbB and ExbD, which contribute to the stability of the protein and support the TonB-dependent active transport across the outer membrane.
# ExbB and ExbD interact with each other, which has been suggested to play a part in the mechanism of energy transduction

==3D structures of TonB==

[[TonB]]

== References==
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