View source for Vesicle-associated membrane protein

<StructureSection load='5w5c' size='340' side='right' caption='Rat vesicle-associated membrane protein 2 SNARE motif (grey) complex with syntaxin-1A SNARE motif (green), SNAP25 SNARE motif (pink and yellow), complexin-1 (magenta), synaptotagmin-1 (cyan), glycerol and Mg+2 ion (green) (PDB code [[5w5c]])' scene='80/801800/Cv/1'>
== Function ==

'''Vesicle-associated membrane protein''' (VAMP) has been implicated in synaptic vesicle docking and fusion<ref>PMID:7929121</ref>.

* '''VAMP2''' is part of the protein complex which in volve [[Syntaxin]] and SNAP25 which is involved in the docking or fusion of synaptic vesicles with the presynaptic <ref>PMID:21733851</ref>.<br />
* '''VAMP4''' is involved in the pathway that functions to remove an inhibitor (probably synaptotagmin) of calcium-triggered exocytosis during the maturation of secretory granules.<br />
* '''VAMP8''' is involved in the homotypic fusion of secretary granules<ref>PMID:21733851</ref>.<br />

'''Vesicle-associated membrane protein-associated protein''' (VAP) are endoplasmic reticulum proteins functioning in vesicle traffic, neurotransmitter release, microtubule organisation, lipid transport and unfolded protein transport<ref>PMID:18468439</ref>.

== Relevance ==

Decreased levels of VAMP2 and α-synuclein correlate with duration of dementia<ref>PMID:26639969</ref>.  Decreased level of VAMPB/C is observed in ALS spinal cord <ref>PMID:18701194</ref>.

== Structural highlights ==

There is a remarkable shape complementarity between the proteins involved in the SNARE-complexin-synaptotagmin interface<ref>PMID:28813412</ref>.

==3D structures of vesicle-associated membrane protein==
[[Vesicle-associated membrane protein 3D structures]]

== References ==
<references/>
</StructureSection>
[[Category:Topic Page]]