View source for WD repeat-containing protein

<StructureSection load='' size='340' side='right' caption='Human WD-repeat protein 5 (deepskyblue) complex with histone H3 peptide (magenta) (PDB code [[2h9m]])' scene='70/709459/Cv/1'>
== Function ==
'''WD repeat-containing proteins''' or '''ribosome biogenesis protein WDR''' (WDR) contain 4 or more repeating WD units. WD repeats are ca. 40 amino acid long usually bordered by Gly-His and Trp-Asp (WD).  All WDRs form a β-propeller structure.  WDRs have critical roles in many biological functions like signal transduction, transcription regulation and apoptosis<ref>PMID:11814058</ref>.  <br />
*'''WD-repeat protein 5''' (WDR5) contains 7 WD repeats.  WDR5 contributes to histone modification.  It may position the N-terminal of histone H3 for efficient methylation at Lys4.  This methylation is implicated in the control of activation of cell lineage genes during embryogenesis.  WDR5 interacts with histone-lysine N-methyltransferase (MLL)<ref>PMID:21531708</ref>.  <br />
*'''WD repeat-containing protein 48 and 20''' act as regulators of deubiquinating complexes.

*'''WD repeat-containing protein 41''' is the non-catalytic component of C9orf72-SMCR8 complex which regulates autophagy<ref>PMID:27193190</ref>.  <br />
*'''WD repeat-containing protein 55''' is a modulator of rRNA synthesis.  <br />
*'''WD repeat-containing protein 61''' is a component of PAF1 complex which functions during RNA transcription.  <br />
*'''WD repeat-containing protein 91''' functions as negative regulator of the PI3 kinase/PI3K activity in endosomal transport<ref>PMID:27126989</ref>.  <br />
*'''WD repeat-containing protein 92''' is a modulator of apoptosis.  <br />
*'''WD repeat-containing protein SLP1''' is required for mad2-dependent spindle checkpoint activation.  <br />
*'''WD repeat protein CSA''' or '''DNA excision repair protein ERCC-8''' is part of the transcription-coupled repair complex<ref>PMID:32355176</ref>.  <br />
== Disease ==
Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>.

== Structural highlights ==
The <scene name='70/709459/Cv/4'>histone Arg2 residue inserts into the central pore</scene> of the WDR5 β-propellor structure acting like an anchoring pin <scene name='70/709459/Cv/3'>forming numerous hydrogen bonds and cation-π interactions</scene><ref>PMID:16946699</ref>. Water molecules are shown as red spheres.
== 3D Structures of WD-repeat protein ==
[[WD-repeat protein 3D structures]]
</StructureSection>

== References ==
<references/>
[[Category:Topic Page]]