1bs0 - Revision history

OCA at 23:21, 27 December 2023

2023-12-27T23:21:57Z

← Older revision		Revision as of 23:21, 27 December 2023
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	<StructureSection load='1bs0' size='340' side='right'caption='[[1bs0]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1bs0' size='340' side='right'caption='[[1bs0]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bs0]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BS0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1BS0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bs0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BS0 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>BIOF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~562~~ "~~Bacillus coli~~" ~~Migula 1895])</td~~><~~/tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47]~~ </~~span~~></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bs0 OCA], [https://pdbe.org/1bs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bs0 RCSB], [https://www.ebi.ac.uk/pdbsum/1bs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bs0 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1bs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bs0 OCA], [~~http~~://pdbe.org/1bs0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1bs0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1bs0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1bs0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/BIOF_ECOLI BIOF_ECOLI]] Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Can also use pimeloyl-CoA instead of pimeloyl-ACP as substrate, but it is believed that pimeloyl-ACP rather than pimeloyl-CoA is the physiological substrate of BioF.<ref>PMID:20693992</ref>		[https://www.uniprot.org/uniprot/BIOF_ECOLI BIOF_ECOLI] Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Can also use pimeloyl-CoA instead of pimeloyl-ACP as substrate, but it is believed that pimeloyl-ACP rather than pimeloyl-CoA is the physiological substrate of BioF.<ref>PMID:20693992</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Transferase]]~~		[[Category: Alexeev D]]
	[[Category: Alexeev, D]]		[[Category: Alexeeva M]]
	[[Category: Alexeeva, M]]		[[Category: Baxter RL]]
	[[Category: Baxter~~, R L~~]]		[[Category: Campopiano DJ]]
	[[Category: Campopiano~~, D J~~]]		[[Category: Sawyer L]]
	[[Category: Sawyer, L]]		[[Category: Webster SP]]
	[[Category: Webster~~, S P]]~~
	~~[[Category: 8-amino-7-ketopelargonate synthase]]~~
	~~[[Category: 8-amino-7-oxonanoate synthase]]~~
	~~[[Category: Biotin biosynthesis]]~~
	~~[[Category: Plp-dependent acyl-coa synthase~~]]

OCA at 10:15, 18 November 2020

2020-11-18T10:15:24Z

← Older revision		Revision as of 10:15, 18 November 2020
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	==PLP-DEPENDENT ACYL-COA SYNTHASE==		==PLP-DEPENDENT ACYL-COA SYNTHASE==
	<StructureSection load='1bs0' size='340' side='right' caption='[[1bs0]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1bs0' size='340' side='right'caption='[[1bs0]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bs0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BS0 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1BS0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bs0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BS0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1BS0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIOF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIOF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1bs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bs0 OCA], [http://pdbe.org/1bs0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bs0 RCSB], [http://www.ebi.ac.uk/pdbsum/1bs0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bs0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1bs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bs0 OCA], [http://pdbe.org/1bs0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bs0 RCSB], [http://www.ebi.ac.uk/pdbsum/1bs0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bs0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bs/1bs0_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bs/1bs0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
			[[Category: Large Structures]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Alexeev, D]]		[[Category: Alexeev, D]]

OCA at 08:11, 29 November 2017

2017-11-29T08:11:53Z

← Older revision		Revision as of 08:11, 29 November 2017
Line 1:		Line 1:

	==PLP-DEPENDENT ACYL-COA SYNTHASE==		==PLP-DEPENDENT ACYL-COA SYNTHASE==
	<StructureSection load='1bs0' size='340' side='right' caption='[[1bs0]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1bs0' size='340' side='right' caption='[[1bs0]], [[Resolution\|resolution]] 1.65Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIOF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIOF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bs0 OCA], [http://pdbe.org/1bs0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bs0 RCSB], [http://www.ebi.ac.uk/pdbsum/1bs0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bs0 OCA], [http://pdbe.org/1bs0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bs0 RCSB], [http://www.ebi.ac.uk/pdbsum/1bs0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bs0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 06:06, 10 February 2016

2016-02-10T06:06:00Z

← Older revision		Revision as of 06:06, 10 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bs0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:06, 11 September 2015

2015-09-11T06:06:14Z

← Older revision		Revision as of 06:06, 11 September 2015
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	<StructureSection load='1bs0' size='340' side='right' caption='[[1bs0]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='1bs0' size='340' side='right' caption='[[1bs0]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bs0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BS0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bs0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BS0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIOF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIOF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~8-amino-7-oxononanoate_synthase 8-amino-7-oxononanoate synthase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bs0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bs0 RCSB], [http://www.ebi.ac.uk/pdbsum/1bs0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bs0 OCA], [http://pdbe.org/1bs0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bs0 RCSB], [http://www.ebi.ac.uk/pdbsum/1bs0 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1bs0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~8-amino-7-oxononanoate synthase~~]]		[[Category: Bacillus coli migula 1895]]
	[[Category: ~~Escherichia coli~~]]		[[Category: Transferase]]
	[[Category: Alexeev, D]]		[[Category: Alexeev, D]]
	[[Category: Alexeeva, M]]		[[Category: Alexeeva, M]]
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	[[Category: Biotin biosynthesis]]		[[Category: Biotin biosynthesis]]
	[[Category: Plp-dependent acyl-coa synthase]]		[[Category: Plp-dependent acyl-coa synthase]]
	~~[[Category: Transferase]]~~

OCA at 12:19, 25 December 2014

2014-12-25T12:19:59Z

← Older revision		Revision as of 12:19, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bs0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bs0 RCSB], [http://www.ebi.ac.uk/pdbsum/1bs0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bs0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bs0 RCSB], [http://www.ebi.ac.uk/pdbsum/1bs0 PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/BIOF_ECOLI BIOF_ECOLI]] Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Can also use pimeloyl-CoA instead of pimeloyl-ACP as substrate, but it is believed that pimeloyl-ACP rather than pimeloyl-CoA is the physiological substrate of BioF.<ref>PMID:20693992</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:43, 22 December 2014

2014-12-22T10:43:23Z

← Older revision		Revision as of 10:43, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bs0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BS0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bs0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BS0 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIOF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIOF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/8-amino-7-oxononanoate_synthase 8-amino-7-oxononanoate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/8-amino-7-oxononanoate_synthase 8-amino-7-oxononanoate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bs0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bs0 RCSB], [http://www.ebi.ac.uk/pdbsum/1bs0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bs0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bs0 RCSB], [http://www.ebi.ac.uk/pdbsum/1bs0 PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: 8-amino-7-oxononanoate synthase]]		[[Category: 8-amino-7-oxononanoate synthase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Alexeev, D.]]		[[Category: Alexeev, D]]
	[[Category: Alexeeva, M.]]		[[Category: Alexeeva, M]]
	[[Category: Baxter, R L.]]		[[Category: Baxter, R L]]
	[[Category: Campopiano, D J.]]		[[Category: Campopiano, D J]]
	[[Category: Sawyer, L.]]		[[Category: Sawyer, L]]
	[[Category: Webster, S P.]]		[[Category: Webster, S P]]
	[[Category: 8-amino-7-ketopelargonate synthase]]		[[Category: 8-amino-7-ketopelargonate synthase]]
	[[Category: 8-amino-7-oxonanoate synthase]]		[[Category: 8-amino-7-oxonanoate synthase]]

OCA at 09:42, 13 August 2014

2014-08-13T09:42:32Z

← Older revision		Revision as of 09:42, 13 August 2014
Line 1:		Line 1:
	[[Image:~~1bs0~~.~~png~~\|~~left~~\|~~200px~~]]		==PLP-DEPENDENT ACYL-COA SYNTHASE==
			<StructureSection load='1bs0' size='340' side='right' caption='[[1bs0]], [[Resolution\|resolution]] 1.65Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1bs0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BS0 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BIOF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/8-amino-7-oxononanoate_synthase 8-amino-7-oxononanoate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bs0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bs0 RCSB], [http://www.ebi.ac.uk/pdbsum/1bs0 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bs/1bs0_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			8-Amino-7-oxononanoate synthase (or 8-amino-7-ketopelargonate synthase; EC 2.3.1.47; AONS) catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. We have cloned, over-expressed and purified AONS from Escherichia coli and determined the crystal structures of the apo and PLP-bound forms of the enzyme. The protein is a symmetrical homodimer with a tertiary structure and active site organisation similar to, but distinct from, those of other PLP-dependent enzymes whose three-dimensional structures are known. The critical PLP-binding lysine of AONS is located at the end of a deep cleft that allows access of the pantothenate arm of pimeloyl-CoA. A cluster of positively charged residues at the entrance to this cleft forms a putative diphosphate binding site for CoA. The structure of E. coli AONS enables identification of the key residues of the PLP-binding site and thus provides a framework with which to understand the biochemical mechanism, which is similar to that catalysed by 5-aminolevulinate synthase and two other alpha-oxoamine synthases. Although AONS has a low overall sequence similarity with the catalytic domains of other alpha-oxoamine synthases, the structure reveals the regions of significant identity to be functionally important. This suggests that the organisation of the conserved catalytic residues in the active site is similar for all enzymes of this sub-class of PLP-dependent enzymes and they share a common mechanism. Knowledge of the three-dimensional structure of AONS will enable characterisation of the structural features of this enzyme sub-family that are responsible for this important type of reaction.

	~~{{STRUCTURE_1bs0\| PDB=1bs0 \| SCENE= }}~~		The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme.,Alexeev D, Alexeeva M, Baxter RL, Campopiano DJ, Webster SP, Sawyer L J Mol Biol. 1998 Nov 27;284(2):401-19. PMID:9813126<ref>PMID:9813126</ref>

	~~===PLP-DEPENDENT ACYL-COA SYNTHASE===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_9813126}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[1bs0]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1BS0 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:009813126<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: 8-amino-7-oxononanoate synthase]]		[[Category: 8-amino-7-oxononanoate synthase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]

OCA: Protected "1bs0" [edit=sysop:move=sysop]

2012-10-21T20:14:03Z

Protected "1bs0" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:14, 21 October 2012
(No difference)

OCA at 20:13, 21 October 2012

2012-10-21T20:13:59Z

← Older revision		Revision as of 20:13, 21 October 2012
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	~~{{Seed}}~~
	[[Image:1bs0.png\|left\|200px]]		[[Image:1bs0.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_1bs0", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_1bs0\| PDB=1bs0 \| SCENE= }}		{{STRUCTURE_1bs0\| PDB=1bs0 \| SCENE= }}

	===PLP-DEPENDENT ACYL-COA SYNTHASE===		===PLP-DEPENDENT ACYL-COA SYNTHASE===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_9813126}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 9813126 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_9813126}}		{{ABSTRACT_PUBMED_9813126}}

	==About this Structure==		==About this Structure==
	~~1BS0~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BS0 OCA].		[[1bs0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BS0 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~9813126~~</ref><references group="xtra"/>		<ref group="xtra">PMID:009813126</ref><references group="xtra"/>
	[[Category: 8-amino-7-oxononanoate synthase]]		[[Category: 8-amino-7-oxononanoate synthase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
Line 36:		Line 24:
	[[Category: Biotin biosynthesis]]		[[Category: Biotin biosynthesis]]
	[[Category: Plp-dependent acyl-coa synthase]]		[[Category: Plp-dependent acyl-coa synthase]]
			[[Category: Transferase]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 16:00:37 2009''~~