1bug - Revision history

OCA at 07:12, 9 October 2024

2024-10-09T07:12:26Z

← Older revision		Revision as of 07:12, 9 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bu/1bug_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bu/1bug_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 23:22, 27 December 2023

2023-12-27T23:22:11Z

← Older revision		Revision as of 23:22, 27 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ipomoea_batatas Ipomoea batatas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BUG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ipomoea_batatas Ipomoea batatas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BUG FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>~~, ~~<scene name='pdbligand=URS:N-PHENYLTHIOUREA'>URS</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1bt1\|1bt1]], [[1bt2\|1bt2]], [[1bt3\|1bt3]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=URS:N-PHENYLTHIOUREA'>URS</scene></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Catechol_oxidase Catechol oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.1 1.10.3.1]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bug OCA], [https://pdbe.org/1bug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bug RCSB], [https://www.ebi.ac.uk/pdbsum/1bug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bug ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bug OCA], [https://pdbe.org/1bug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bug RCSB], [https://www.ebi.ac.uk/pdbsum/1bug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bug ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PPO1_IPOBA PPO1_IPOBA]] Catalyzes the oxidation of mono- and o-diphenols to o-diquinones.		[https://www.uniprot.org/uniprot/PPO1_IPOBA PPO1_IPOBA] Catalyzes the oxidation of mono- and o-diphenols to o-diquinones.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Catechol oxidase]]~~
	[[Category: Ipomoea batatas]]		[[Category: Ipomoea batatas]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Eicken, C]]		[[Category: Eicken C]]
	[[Category: Klabunde, T]]		[[Category: Klabunde T]]
	[[Category: Krebs, B]]		[[Category: Krebs B]]
	[[Category: Sacchettini~~, J C]]~~		[[Category: Sacchettini JC]]
	~~[[Category: Dicopper enzyme]]~~
	~~[[Category: Ipomoea batata]]~~
	~~[[Category: Oxidoreductase~~]]

OCA at 10:29, 14 July 2021

2021-07-14T10:29:46Z

← Older revision		Revision as of 10:29, 14 July 2021
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	<StructureSection load='1bug' size='340' side='right'caption='[[1bug]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1bug' size='340' side='right'caption='[[1bug]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bug]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ipomoea_batatas Ipomoea batatas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1BUG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ipomoea_batatas Ipomoea batatas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BUG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=URS:N-PHENYLTHIOUREA'>URS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=URS:N-PHENYLTHIOUREA'>URS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bt1\|1bt1]], [[1bt2\|1bt2]], [[1bt3\|1bt3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bt1\|1bt1]], [[1bt2\|1bt2]], [[1bt3\|1bt3]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Catechol_oxidase Catechol oxidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.1 1.10.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Catechol_oxidase Catechol oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.1 1.10.3.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bug OCA], [~~http~~://pdbe.org/1bug PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1bug RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1bug PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1bug ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bug OCA], [https://pdbe.org/1bug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bug RCSB], [https://www.ebi.ac.uk/pdbsum/1bug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bug ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PPO1_IPOBA PPO1_IPOBA]] Catalyzes the oxidation of mono- and o-diphenols to o-diquinones.		[[https://www.uniprot.org/uniprot/PPO1_IPOBA PPO1_IPOBA]] Catalyzes the oxidation of mono- and o-diphenols to o-diquinones.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:30, 10 October 2019

2019-10-10T07:30:07Z

← Older revision		Revision as of 07:30, 10 October 2019
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	==CATECHOL OXIDASE FROM IPOMOEA BATATAS (SWEET POTATOES)-INHIBITOR COMPLEX WITH PHENYLTHIOUREA (PTU)==		==CATECHOL OXIDASE FROM IPOMOEA BATATAS (SWEET POTATOES)-INHIBITOR COMPLEX WITH PHENYLTHIOUREA (PTU)==
	<StructureSection load='1bug' size='340' side='right' caption='[[1bug]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1bug' size='340' side='right'caption='[[1bug]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ipomoea_batatas Ipomoea batatas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BUG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ipomoea_batatas Ipomoea batatas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BUG FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bu/1bug_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bu/1bug_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Catechol oxidase]]		[[Category: Catechol oxidase]]
	[[Category: Ipomoea batatas]]		[[Category: Ipomoea batatas]]
			[[Category: Large Structures]]
	[[Category: Eicken, C]]		[[Category: Eicken, C]]
	[[Category: Klabunde, T]]		[[Category: Klabunde, T]]

OCA at 08:20, 29 November 2017

2017-11-29T08:20:07Z

← Older revision		Revision as of 08:20, 29 November 2017
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	==CATECHOL OXIDASE FROM IPOMOEA BATATAS (SWEET POTATOES)-INHIBITOR COMPLEX WITH PHENYLTHIOUREA (PTU)==		==CATECHOL OXIDASE FROM IPOMOEA BATATAS (SWEET POTATOES)-INHIBITOR COMPLEX WITH PHENYLTHIOUREA (PTU)==
	<StructureSection load='1bug' size='340' side='right' caption='[[1bug]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1bug' size='340' side='right' caption='[[1bug]], [[Resolution\|resolution]] 2.70Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bt1\|1bt1]], [[1bt2\|1bt2]], [[1bt3\|1bt3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bt1\|1bt1]], [[1bt2\|1bt2]], [[1bt3\|1bt3]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_oxidase Catechol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.1 1.10.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_oxidase Catechol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.1 1.10.3.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bug OCA], [http://pdbe.org/1bug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bug RCSB], [http://www.ebi.ac.uk/pdbsum/1bug PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bug OCA], [http://pdbe.org/1bug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bug RCSB], [http://www.ebi.ac.uk/pdbsum/1bug PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bug ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 19:19, 8 February 2016

2016-02-08T19:19:01Z

← Older revision		Revision as of 19:19, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bug ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:36, 10 September 2015

2015-09-10T14:36:55Z

← Older revision		Revision as of 14:36, 10 September 2015
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bt1\|1bt1]], [[1bt2\|1bt2]], [[1bt3\|1bt3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bt1\|1bt1]], [[1bt2\|1bt2]], [[1bt3\|1bt3]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_oxidase Catechol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.1 1.10.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_oxidase Catechol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.1 1.10.3.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bug RCSB], [http://www.ebi.ac.uk/pdbsum/1bug PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bug OCA], [http://pdbe.org/1bug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bug RCSB], [http://www.ebi.ac.uk/pdbsum/1bug PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1bug" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:35, 25 December 2014

2014-12-25T01:35:58Z

← Older revision		Revision as of 01:35, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bug RCSB], [http://www.ebi.ac.uk/pdbsum/1bug PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bug RCSB], [http://www.ebi.ac.uk/pdbsum/1bug PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PPO1_IPOBA PPO1_IPOBA]] Catalyzes the oxidation of mono- and o-diphenols to o-diquinones.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:25, 22 December 2014

2014-12-22T10:25:49Z

← Older revision		Revision as of 10:25, 22 December 2014
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1bug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ipomoea_batatas Ipomoea batatas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BUG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1bug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ipomoea_batatas Ipomoea batatas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BUG FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=URS:N-PHENYLTHIOUREA'>URS</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=URS:N-PHENYLTHIOUREA'>URS</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bt1\|1bt1]], [[1bt2\|1bt2]], [[1bt3\|1bt3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bt1\|1bt1]], [[1bt2\|1bt2]], [[1bt3\|1bt3]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_oxidase Catechol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.1 1.10.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_oxidase Catechol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.1 1.10.3.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bug RCSB], [http://www.ebi.ac.uk/pdbsum/1bug PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bug RCSB], [http://www.ebi.ac.uk/pdbsum/1bug PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Catechol oxidase]]		[[Category: Catechol oxidase]]
	[[Category: Ipomoea batatas]]		[[Category: Ipomoea batatas]]
	[[Category: Eicken, C.]]		[[Category: Eicken, C]]
	[[Category: Klabunde, T.]]		[[Category: Klabunde, T]]
	[[Category: Krebs, B.]]		[[Category: Krebs, B]]
	[[Category: Sacchettini, J C~~.]]~~		[[Category: Sacchettini, J C]]
	~~[[Category: Catechol oxidase~~]]
	[[Category: Dicopper enzyme]]		[[Category: Dicopper enzyme]]
	[[Category: Ipomoea batata]]		[[Category: Ipomoea batata]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 09:48, 13 August 2014

2014-08-13T09:48:36Z

← Older revision		Revision as of 09:48, 13 August 2014
Line 1:		Line 1:
	[[Image:~~1bug~~.~~png~~\|~~left~~\|~~200px~~]]		==CATECHOL OXIDASE FROM IPOMOEA BATATAS (SWEET POTATOES)-INHIBITOR COMPLEX WITH PHENYLTHIOUREA (PTU)==
			<StructureSection load='1bug' size='340' side='right' caption='[[1bug]], [[Resolution\|resolution]] 2.70Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1bug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ipomoea_batatas Ipomoea batatas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BUG FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=URS:N-PHENYLTHIOUREA'>URS</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bt1\|1bt1]], [[1bt2\|1bt2]], [[1bt3\|1bt3]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_oxidase Catechol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.1 1.10.3.1] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bug RCSB], [http://www.ebi.ac.uk/pdbsum/1bug PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bu/1bug_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Catechol oxidases are ubiquitous plant enzymes containing a dinuclear copper center. In the wound-response mechanism of the plant they catalyze the oxidation of a broad range of ortho-diphenols to the corresponding o-quinones coupled with the reduction of oxygen to water. The crystal structures of the enzyme from sweet potato in the resting dicupric Cu(II)-Cu(II) state, the reduced dicuprous Cu(I)-Cu(I) form, and in complex with the inhibitor phenylthiourea were analyzed. The catalytic copper center is accommodated in a central four-helix-bundle located in a hydrophobic pocket close to the surface. Both metal binding sites are composed of three histidine ligands. His 109, ligated to the CuA site, is covalently linked to Cys 92 by an unusual thioether bond. Based on biochemical, spectroscopic and the presented structural data, a catalytical mechanism is proposed in which one of the oxygen atoms of the diphenolic substrate binds to CuB of the oxygenated enzyme.

	~~{{STRUCTURE_1bug\| PDB=1bug \| SCENE= }}~~		Crystal structure of a plant catechol oxidase containing a dicopper center.,Klabunde T, Eicken C, Sacchettini JC, Krebs B Nat Struct Biol. 1998 Dec;5(12):1084-90. PMID:9846879<ref>PMID:9846879</ref>

	~~===CATECHOL OXIDASE FROM IPOMOEA BATATAS (SWEET POTATOES)-INHIBITOR COMPLEX WITH PHENYLTHIOUREA (PTU)===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_9846879}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[1bug]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Ipomoea_batatas Ipomoea batatas]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1BUG OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:009846879<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Catechol oxidase]]		[[Category: Catechol oxidase]]
	[[Category: Ipomoea batatas]]		[[Category: Ipomoea batatas]]