1c4e - Revision history

OCA at 06:02, 5 July 2023

2023-07-05T06:02:44Z

← Older revision		Revision as of 06:02, 5 July 2023
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	==GURMARIN FROM GYMNEMA SYLVESTRE==		==GURMARIN FROM GYMNEMA SYLVESTRE==
	<StructureSection load='1c4e' size='340' side='right'caption='[[1c4e~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='1c4e' size='340' side='right'caption='[[1c4e]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C4E FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene~~></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2gur\|2gur]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [https://pdbe.org/1c4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [https://www.ebi.ac.uk/pdbsum/1c4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [https://pdbe.org/1c4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [https://www.ebi.ac.uk/pdbsum/1c4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/GUR_GYMSY GUR_GYMSY]] Suppresses strongly the sweet taste responses in the rat with high specificity to sucrose, glucose, glycine, and saccharin. This effect is reversible, but complete recovery of the suppressed responses required at least 3h. Gurmarin showed no effect or only a very weak effect on the sweet taste sensation in humans.		[https://www.uniprot.org/uniprot/GUR_GYMSY GUR_GYMSY] Suppresses strongly the sweet taste responses in the rat with high specificity to sucrose, glucose, glycine, and saccharin. This effect is reversible, but complete recovery of the suppressed responses required at least 3h. Gurmarin showed no effect or only a very weak effect on the sweet taste sensation in humans.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	[[Category: Gymnema sylvestre]]		[[Category: Gymnema sylvestre]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Dingley~~, A J~~]]		[[Category: Dingley AJ]]
	[[Category: Fletcher~~, J I~~]]		[[Category: Fletcher JI]]
	[[Category: King~~, G F]]~~		[[Category: King GF]]
	~~[[Category: Cystine knot]]~~
	~~[[Category: Gurmarin]]~~
	~~[[Category: Plant protein]]~~
	~~[[Category: Sweet taste suppression]]~~
	~~[[Category: Sweet taste transduction~~]]

OCA at 09:17, 29 September 2021

2021-09-29T09:17:16Z

← Older revision		Revision as of 09:17, 29 September 2021
Line 3:		Line 3:
	<StructureSection load='1c4e' size='340' side='right'caption='[[1c4e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1c4e' size='340' side='right'caption='[[1c4e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c4e]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1C4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C4E FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gur\|2gur]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gur\|2gur]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [~~http~~://pdbe.org/1c4e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1c4e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1c4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [https://pdbe.org/1c4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [https://www.ebi.ac.uk/pdbsum/1c4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/GUR_GYMSY GUR_GYMSY]] Suppresses strongly the sweet taste responses in the rat with high specificity to sucrose, glucose, glycine, and saccharin. This effect is reversible, but complete recovery of the suppressed responses required at least 3h. Gurmarin showed no effect or only a very weak effect on the sweet taste sensation in humans.		[[https://www.uniprot.org/uniprot/GUR_GYMSY GUR_GYMSY]] Suppresses strongly the sweet taste responses in the rat with high specificity to sucrose, glucose, glycine, and saccharin. This effect is reversible, but complete recovery of the suppressed responses required at least 3h. Gurmarin showed no effect or only a very weak effect on the sweet taste sensation in humans.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:26, 10 October 2019

2019-10-10T07:26:12Z

← Older revision		Revision as of 07:26, 10 October 2019
Line 1:		Line 1:

	==GURMARIN FROM GYMNEMA SYLVESTRE==		==GURMARIN FROM GYMNEMA SYLVESTRE==
	<StructureSection load='1c4e' size='340' side='right' caption='[[1c4e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1c4e' size='340' side='right'caption='[[1c4e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C4E FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Gymnema sylvestre]]		[[Category: Gymnema sylvestre]]
			[[Category: Large Structures]]
	[[Category: Dingley, A J]]		[[Category: Dingley, A J]]
	[[Category: Fletcher, J I]]		[[Category: Fletcher, J I]]

OCA at 11:20, 24 August 2017

2017-08-24T11:20:43Z

← Older revision		Revision as of 11:20, 24 August 2017
Line 1:		Line 1:

	==GURMARIN FROM GYMNEMA SYLVESTRE==		==GURMARIN FROM GYMNEMA SYLVESTRE==
	<StructureSection load='1c4e' size='340' side='right' caption='[[1c4e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1c4e' size='340' side='right' caption='[[1c4e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gur\|2gur]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gur\|2gur]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [http://pdbe.org/1c4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [http://www.ebi.ac.uk/pdbsum/1c4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [http://pdbe.org/1c4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [http://www.ebi.ac.uk/pdbsum/1c4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1c4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 17:11, 11 September 2015

2015-09-11T17:11:38Z

← Older revision		Revision as of 17:11, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gur\|2gur]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gur\|2gur]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [http://www.ebi.ac.uk/pdbsum/1c4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [http://pdbe.org/1c4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [http://www.ebi.ac.uk/pdbsum/1c4e PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1c4e" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:26, 25 December 2014

2014-12-25T19:26:44Z

← Older revision		Revision as of 19:26, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [http://www.ebi.ac.uk/pdbsum/1c4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [http://www.ebi.ac.uk/pdbsum/1c4e PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/GUR_GYMSY GUR_GYMSY]] Suppresses strongly the sweet taste responses in the rat with high specificity to sucrose, glucose, glycine, and saccharin. This effect is reversible, but complete recovery of the suppressed responses required at least 3h. Gurmarin showed no effect or only a very weak effect on the sweet taste sensation in humans.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:20, 22 December 2014

2014-12-22T09:20:54Z

← Older revision		Revision as of 09:20, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1c4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[1c4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C4E FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gur\|2gur]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gur\|2gur]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [http://www.ebi.ac.uk/pdbsum/1c4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [http://www.ebi.ac.uk/pdbsum/1c4e PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Gymnema sylvestre]]		[[Category: Gymnema sylvestre]]
	[[Category: Dingley, A J.]]		[[Category: Dingley, A J]]
	[[Category: Fletcher, J I.]]		[[Category: Fletcher, J I]]
	[[Category: King, G F.]]		[[Category: King, G F]]
	[[Category: Cystine knot]]		[[Category: Cystine knot]]
	[[Category: Gurmarin]]		[[Category: Gurmarin]]

OCA at 17:12, 20 August 2014

2014-08-20T17:12:04Z

← Older revision		Revision as of 17:12, 20 August 2014
Line 1:		Line 1:
	[[~~Image~~:~~1c4e~~.~~png~~\|~~left~~\|~~200px~~]]		==GURMARIN FROM GYMNEMA SYLVESTRE==
			<StructureSection load='1c4e' size='340' side='right' caption='[[1c4e]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1c4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C4E FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gur\|2gur]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [http://www.ebi.ac.uk/pdbsum/1c4e PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Gurmarin is a 35-residue polypeptide from the Asclepiad vine Gymnema sylvestre. It has been utilised as a pharmacological tool in the study of sweet-taste transduction because of its ability to selectively inhibit the neural response to sweet tastants in rats. We have chemically synthesised and folded gurmarin and determined its three-dimensional solution structure to high resolution using two-dimensional NMR spectroscopy. Structure calculations utilised 612 interproton-distance, 19 dihedral-angle, and 18 hydrogen-bond restraints. The structure is well defined for residues 3-34, with backbone and heavy atom rms differences of 0.27 +/- 0.09 A and 0.73 +/- 0.09 A, respectively. Gurmarin adopts a compact structure containing an antiparallel beta-hairpin (residues 22-34), several well-defined beta-turns, and a cystine-knot motif commonly observed in toxic and inhibitory polypeptides. Despite striking structural homology with delta-atracotoxin, a spider neurotoxin known to slow the inactivation of voltage-gated Na+ channels, we show that gurmarin has no effect on a variety of voltage-sensitive channels.

	~~{{STRUCTURE_1c4e\| PDB=1c4e \| SCENE= }}~~		High-resolution solution structure of gurmarin, a sweet-taste-suppressing plant polypeptide.,Fletcher JI, Dingley AJ, Smith R, Connor M, Christie MJ, King GF Eur J Biochem. 1999 Sep;264(2):525-33. PMID:10491100<ref>PMID:10491100</ref>

	~~===GURMARIN FROM GYMNEMA SYLVESTRE===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_10491100}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[1c4e]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes~~ the ~~now removed PDB entry [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:010491100<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Gymnema sylvestre]]		[[Category: Gymnema sylvestre]]
	[[Category: Dingley, A J.]]		[[Category: Dingley, A J.]]

OCA: Protected "1c4e" [edit=sysop:move=sysop]

2012-10-21T20:50:46Z

Protected "1c4e" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:50, 21 October 2012
(No difference)

OCA at 20:50, 21 October 2012

2012-10-21T20:50:43Z

← Older revision		Revision as of 20:50, 21 October 2012
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	~~{{Seed}}~~
	[[Image:1c4e.png\|left\|200px]]		[[Image:1c4e.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_1c4e", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_1c4e\| PDB=1c4e \| SCENE= }}		{{STRUCTURE_1c4e\| PDB=1c4e \| SCENE= }}

	===GURMARIN FROM GYMNEMA SYLVESTRE===		===GURMARIN FROM GYMNEMA SYLVESTRE===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_10491100}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 10491100 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_10491100}}		{{ABSTRACT_PUBMED_10491100}}

	==About this Structure==		==About this Structure==
	~~1C4E~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA].		[[1c4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~10491100~~</ref><references group="xtra"/>		<ref group="xtra">PMID:010491100</ref><references group="xtra"/>
	[[Category: Gymnema sylvestre]]		[[Category: Gymnema sylvestre]]
	[[Category: Dingley, A J.]]		[[Category: Dingley, A J.]]
Line 33:		Line 21:
	[[Category: Sweet taste suppression]]		[[Category: Sweet taste suppression]]
	[[Category: Sweet taste transduction]]		[[Category: Sweet taste transduction]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 8 20:06:14 2009''~~