1e8a - Revision history

OCA at 11:56, 13 December 2023

2023-12-13T11:56:05Z

← Older revision		Revision as of 11:56, 13 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1e8a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[1e8a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E8A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8a OCA], [https://pdbe.org/1e8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e8a RCSB], [https://www.ebi.ac.uk/pdbsum/1e8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e8a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8a OCA], [https://pdbe.org/1e8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e8a RCSB], [https://www.ebi.ac.uk/pdbsum/1e8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e8a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/S10AC_HUMAN S10AC_HUMAN]] S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.<ref>PMID:11522286</ref> <ref>PMID:17208591</ref> <ref>PMID:18292089</ref> <ref>PMID:19386136</ref>		[https://www.uniprot.org/uniprot/S10AC_HUMAN S10AC_HUMAN] S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.<ref>PMID:11522286</ref> <ref>PMID:17208591</ref> <ref>PMID:18292089</ref> <ref>PMID:19386136</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Antson~~, A A~~]]		[[Category: Antson AA]]
	[[Category: Bronstein~~, I B~~]]		[[Category: Bronstein IB]]
	[[Category: Dodson~~, G G~~]]		[[Category: Dodson GG]]
	[[Category: Lukanidin~~, E M~~]]		[[Category: Lukanidin EM]]
	[[Category: Maitland~~, N J~~]]		[[Category: Maitland NJ]]
	[[Category: Moroz~~, O V~~]]		[[Category: Moroz OV]]
	[[Category: Murshudov~~, G N~~]]		[[Category: Murshudov GN]]
	[[Category: Skibshoj, I]]		[[Category: Skibshoj I]]
	[[Category: Wilson~~, K S]]~~		[[Category: Wilson KS]]
	~~[[Category: Antifungal protein]]~~
	~~[[Category: Calcium binding]]~~
	~~[[Category: Ef-hand]]~~
	~~[[Category: S100 protein~~]]

OCA at 10:23, 17 February 2021

2021-02-17T10:23:57Z

← Older revision		Revision as of 10:23, 17 February 2021
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	<StructureSection load='1e8a' size='340' side='right'caption='[[1e8a]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='1e8a' size='340' side='right'caption='[[1e8a]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1e8a]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1E8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[1e8a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E8A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8a OCA], [~~http~~://pdbe.org/1e8a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1e8a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1e8a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1e8a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8a OCA], [https://pdbe.org/1e8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e8a RCSB], [https://www.ebi.ac.uk/pdbsum/1e8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e8a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/S10AC_HUMAN S10AC_HUMAN]] S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.<ref>PMID:11522286</ref> <ref>PMID:17208591</ref> <ref>PMID:18292089</ref> <ref>PMID:19386136</ref>		[[https://www.uniprot.org/uniprot/S10AC_HUMAN S10AC_HUMAN]] S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.<ref>PMID:11522286</ref> <ref>PMID:17208591</ref> <ref>PMID:18292089</ref> <ref>PMID:19386136</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[S100 ~~protein~~\|S100 ~~protein~~]]		*[[S100 proteins 3D structures\|S100 proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:32, 10 May 2019

2019-05-10T11:32:47Z

← Older revision		Revision as of 11:32, 10 May 2019
Line 1:		Line 1:

	==The three-dimensional structure of human S100A12==		==The three-dimensional structure of human S100A12==
	<StructureSection load='1e8a' size='340' side='right' caption='[[1e8a]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='1e8a' size='340' side='right'caption='[[1e8a]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1e8a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[1e8a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E8A FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1e8a" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1e8a" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[S100 protein\|S100 protein]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
			[[Category: Large Structures]]
	[[Category: Antson, A A]]		[[Category: Antson, A A]]
	[[Category: Bronstein, I B]]		[[Category: Bronstein, I B]]

OCA at 07:51, 13 December 2017

2017-12-13T07:51:03Z

← Older revision		Revision as of 07:51, 13 December 2017
Line 1:		Line 1:
	==~~THE THREE~~-~~DIMENSIONAL STRUCTURE OF HUMAN~~ S100A12==
			==The three-dimensional structure of human S100A12==
	<StructureSection load='1e8a' size='340' side='right' caption='[[1e8a]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='1e8a' size='340' side='right' caption='[[1e8a]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1e8a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[1e8a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E8A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8a OCA], [http://pdbe.org/1e8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e8a RCSB], [http://www.ebi.ac.uk/pdbsum/1e8a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8a OCA], [http://pdbe.org/1e8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e8a RCSB], [http://www.ebi.ac.uk/pdbsum/1e8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1e8a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/1e8a_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/1e8a_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1e8a" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1e8a" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[S100 protein\|S100 protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:49, 9 February 2016

2016-02-09T20:49:28Z

← Older revision		Revision as of 20:49, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e8a ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:54, 11 September 2015

2015-09-11T01:54:39Z

← Older revision		Revision as of 01:54, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1e8a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[1e8a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E8A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e8a RCSB], [http://www.ebi.ac.uk/pdbsum/1e8a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8a OCA], [http://pdbe.org/1e8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e8a RCSB], [http://www.ebi.ac.uk/pdbsum/1e8a PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1e8a" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 09:26, 25 December 2014

2014-12-25T09:26:37Z

← Older revision		Revision as of 09:26, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e8a RCSB], [http://www.ebi.ac.uk/pdbsum/1e8a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e8a RCSB], [http://www.ebi.ac.uk/pdbsum/1e8a PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/S10AC_HUMAN S10AC_HUMAN]] S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.<ref>PMID:11522286</ref> <ref>PMID:17208591</ref> <ref>PMID:18292089</ref> <ref>PMID:19386136</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 22:11, 22 December 2014

2014-12-22T22:11:52Z

← Older revision		Revision as of 22:11, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1e8a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[1e8a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E8A FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e8a RCSB], [http://www.ebi.ac.uk/pdbsum/1e8a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e8a RCSB], [http://www.ebi.ac.uk/pdbsum/1e8a PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Antson, A A.]]		[[Category: Antson, A A]]
	[[Category: Bronstein, I B.]]		[[Category: Bronstein, I B]]
	[[Category: Dodson, G G.]]		[[Category: Dodson, G G]]
	[[Category: Lukanidin, E M.]]		[[Category: Lukanidin, E M]]
	[[Category: Maitland, N J.]]		[[Category: Maitland, N J]]
	[[Category: Moroz, O V.]]		[[Category: Moroz, O V]]
	[[Category: Murshudov, G N.]]		[[Category: Murshudov, G N]]
	[[Category: Skibshoj, I.]]		[[Category: Skibshoj, I]]
	[[Category: Wilson, K S.]]		[[Category: Wilson, K S]]
	[[Category: Antifungal protein]]		[[Category: Antifungal protein]]
	[[Category: Calcium binding]]		[[Category: Calcium binding]]
	[[Category: Ef-hand]]		[[Category: Ef-hand]]
	[[Category: S100 protein]]		[[Category: S100 protein]]

OCA at 16:05, 29 September 2014

2014-09-29T16:05:49Z

← Older revision		Revision as of 16:05, 29 September 2014
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	[[Image:~~1e8a~~.~~png~~\|~~left~~\|~~200px~~]]		==THE THREE-DIMENSIONAL STRUCTURE OF HUMAN S100A12==
			<StructureSection load='1e8a' size='340' side='right' caption='[[1e8a]], [[Resolution\|resolution]] 1.95Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1e8a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E8A FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1e8a RCSB], [http://www.ebi.ac.uk/pdbsum/1e8a PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/1e8a_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The crystal structure of human EF-hand calcium-binding protein S100A12 in its calcium-bound form has been determined to 1.95 A resolution by molecular replacement using the structure of the S100B protein. The S100 family members are homologous to calmodulin and other related EF-hand calcium-binding proteins. Like the majority of S100 proteins, S100A12 is a dimer, with the interface between the two subunits being composed mostly of hydrophobic residues. The fold of S100A12 is similar to the other known crystal and solution structures of S100 proteins, except for the linker region between the two EF-hand motifs. Sequence and structure comparison between members of the S100 family suggests that the target-binding region in S100A12 is formed by the linker region and C-terminal residues of one subunit and the N-terminal residues of another subunit of the dimer. The N-terminal region of the target-binding site includes two glutamates that are conserved in most of the S100 sequences. The comparison also provided a better understanding of the role of the residues important for intra- and inter-subunit hydrophobic interactions. The precise role of S100A12 in cell behaviour is yet undefined, as is the case for the whole family, although it has been shown that the interaction of S100A12 with the RAGE receptor is implicated in inflammatory response.

	~~{{STRUCTURE_1e8a\| PDB=1e8a \| SCENE= }}~~		The three-dimensional structure of human S100A12.,Moroz OV, Antson AA, Murshudov GN, Maitland NJ, Dodson GG, Wilson KS, Skibshoj I, Lukanidin EM, Bronstein IB Acta Crystallogr D Biol Crystallogr. 2001 Jan;57(Pt 1):20-9. PMID:11134923<ref>PMID:11134923</ref>

	~~===THE THREE-DIMENSIONAL STRUCTURE OF HUMAN S100A12===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_11134923}}~~		==See Also==
			*[[S100 protein\|S100 protein]]
	==~~About this Structure~~==		== References ==
	[[~~1e8a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8A OCA~~].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:011134923<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Antson, A A.]]		[[Category: Antson, A A.]]

OCA at 09:30, 16 January 2013

2013-01-16T09:30:48Z

← Older revision		Revision as of 09:30, 16 January 2013
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	[[Image:1e8a.png\|left\|200px]]		[[Image:1e8a.png\|left\|200px]]

	~~<!--~~
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	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_1e8a\| PDB=1e8a \| SCENE= }}		{{STRUCTURE_1e8a\| PDB=1e8a \| SCENE= }}

	===THE THREE-DIMENSIONAL STRUCTURE OF HUMAN S100A12===		===THE THREE-DIMENSIONAL STRUCTURE OF HUMAN S100A12===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_11134923}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_11134923}}		{{ABSTRACT_PUBMED_11134923}}

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	==Reference==		==Reference==
	<ref group="xtra">PMID:~~11134923</ref><ref group="xtra">PMID:10666601~~</ref><references group="xtra"/>		<ref group="xtra">PMID:011134923</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Antson, A A.]]		[[Category: Antson, A A.]]
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	[[Category: Ef-hand]]		[[Category: Ef-hand]]
	[[Category: S100 protein]]		[[Category: S100 protein]]
	~~[[Category: X-ray structure]]~~