1ehs - Revision history

OCA at 06:33, 30 October 2024

2024-10-30T06:33:56Z

← Older revision		Revision as of 06:33, 30 October 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EHS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EHS FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [https://pdbe.org/1ehs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [https://www.ebi.ac.uk/pdbsum/1ehs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ehs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [https://pdbe.org/1ehs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [https://www.ebi.ac.uk/pdbsum/1ehs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ehs ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:47, 22 November 2023

2023-11-22T11:47:41Z

← Older revision		Revision as of 11:47, 22 November 2023
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	==THE STRUCTURE OF ESCHERICHIA COLI HEAT-STABLE ENTEROTOXIN B BY NUCLEAR MAGNETIC RESONANCE AND CIRCULAR DICHROISM==		==THE STRUCTURE OF ESCHERICHIA COLI HEAT-STABLE ENTEROTOXIN B BY NUCLEAR MAGNETIC RESONANCE AND CIRCULAR DICHROISM==
	<StructureSection load='1ehs' size='340' side='right'caption='[[1ehs~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>		<StructureSection load='1ehs' size='340' side='right'caption='[[1ehs]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EHS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EHS FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [https://pdbe.org/1ehs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [https://www.ebi.ac.uk/pdbsum/1ehs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ehs ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [https://pdbe.org/1ehs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [https://www.ebi.ac.uk/pdbsum/1ehs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ehs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/HSTI_ECOLX HSTI_ECOLX]] Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.		[https://www.uniprot.org/uniprot/HSTI_ECOLX HSTI_ECOLX] Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Dreyfus~~, L A~~]]		[[Category: Dreyfus LA]]
	[[Category: Gierasch~~, L M~~]]		[[Category: Gierasch LM]]
	[[Category: Kupersztoch~~, Y M~~]]		[[Category: Kupersztoch YM]]
	[[Category: Rizo, J]]		[[Category: Rizo J]]
	[[Category: Sukumar, M]]		[[Category: Sukumar M]]
	[[Category: Wall, M]]		[[Category: Wall M]]
	~~[[Category: Disulfide]]~~
	~~[[Category: Enterotoxin]]~~
	~~[[Category: Heat-stable~~]]

OCA at 10:40, 16 February 2022

2022-02-16T10:40:29Z

← Older revision		Revision as of 10:40, 16 February 2022
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	<StructureSection load='1ehs' size='340' side='right'caption='[[1ehs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1ehs' size='340' side='right'caption='[[1ehs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EHS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EHS FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [https://pdbe.org/1ehs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [https://www.ebi.ac.uk/pdbsum/1ehs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ehs ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [https://pdbe.org/1ehs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [https://www.ebi.ac.uk/pdbsum/1ehs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ehs ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Bacillus coli migula 1895]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Dreyfus, L A]]		[[Category: Dreyfus, L A]]

OCA at 07:11, 17 March 2021

2021-03-17T07:11:37Z

← Older revision		Revision as of 07:11, 17 March 2021
Line 3:		Line 3:
	<StructureSection load='1ehs' size='340' side='right'caption='[[1ehs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1ehs' size='340' side='right'caption='[[1ehs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1EHS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EHS FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [~~http~~://pdbe.org/1ehs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ehs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ehs ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [https://pdbe.org/1ehs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [https://www.ebi.ac.uk/pdbsum/1ehs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ehs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/HSTI_ECOLX HSTI_ECOLX]] Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.		[[https://www.uniprot.org/uniprot/HSTI_ECOLX HSTI_ECOLX]] Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:47, 12 June 2019

2019-06-12T06:47:56Z

← Older revision		Revision as of 06:47, 12 June 2019
Line 1:		Line 1:

	==THE STRUCTURE OF ESCHERICHIA COLI HEAT-STABLE ENTEROTOXIN B BY NUCLEAR MAGNETIC RESONANCE AND CIRCULAR DICHROISM==		==THE STRUCTURE OF ESCHERICHIA COLI HEAT-STABLE ENTEROTOXIN B BY NUCLEAR MAGNETIC RESONANCE AND CIRCULAR DICHROISM==
	<StructureSection load='1ehs' size='340' side='right' caption='[[1ehs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1ehs' size='340' side='right'caption='[[1ehs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EHS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EHS FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Dreyfus, L A]]		[[Category: Dreyfus, L A]]
	[[Category: Gierasch, L M]]		[[Category: Gierasch, L M]]

OCA at 03:58, 6 September 2017

2017-09-06T03:58:06Z

← Older revision		Revision as of 03:58, 6 September 2017
Line 1:		Line 1:

	==THE STRUCTURE OF ESCHERICHIA COLI HEAT-STABLE ENTEROTOXIN B BY NUCLEAR MAGNETIC RESONANCE AND CIRCULAR DICHROISM==		==THE STRUCTURE OF ESCHERICHIA COLI HEAT-STABLE ENTEROTOXIN B BY NUCLEAR MAGNETIC RESONANCE AND CIRCULAR DICHROISM==
	<StructureSection load='1ehs' size='340' side='right' caption='[[1ehs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1ehs' size='340' side='right' caption='[[1ehs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EHS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EHS FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [http://pdbe.org/1ehs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [http://www.ebi.ac.uk/pdbsum/1ehs PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [http://pdbe.org/1ehs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [http://www.ebi.ac.uk/pdbsum/1ehs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ehs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Bacillus coli migula 1895]]~~
	[[Category: Dreyfus, L A]]		[[Category: Dreyfus, L A]]
	[[Category: Gierasch, L M]]		[[Category: Gierasch, L M]]

OCA at 06:10, 11 September 2015

2015-09-11T06:10:11Z

← Older revision		Revision as of 06:10, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1ehs' size='340' side='right' caption='[[1ehs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1ehs' size='340' side='right' caption='[[1ehs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EHS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EHS FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [http://www.ebi.ac.uk/pdbsum/1ehs PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [http://pdbe.org/1ehs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [http://www.ebi.ac.uk/pdbsum/1ehs PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~HSTI_ECOLI HSTI_ECOLI~~]] Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.		[[http://www.uniprot.org/uniprot/HSTI_ECOLX HSTI_ECOLX]] Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1ehs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia~~ coli]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Dreyfus, L A]]		[[Category: Dreyfus, L A]]
	[[Category: Gierasch, L M]]		[[Category: Gierasch, L M]]

OCA at 12:22, 25 December 2014

2014-12-25T12:22:15Z

← Older revision		Revision as of 12:22, 25 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [http://www.ebi.ac.uk/pdbsum/1ehs PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [http://www.ebi.ac.uk/pdbsum/1ehs PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/HSTI_ECOLI HSTI_ECOLI]] Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 20:21, 22 December 2014

2014-12-22T20:21:28Z

← Older revision		Revision as of 20:21, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EHS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EHS FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [http://www.ebi.ac.uk/pdbsum/1ehs PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [http://www.ebi.ac.uk/pdbsum/1ehs PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Dreyfus, L A.]]		[[Category: Dreyfus, L A]]
	[[Category: Gierasch, L M.]]		[[Category: Gierasch, L M]]
	[[Category: Kupersztoch, Y M.]]		[[Category: Kupersztoch, Y M]]
	[[Category: Rizo, J.]]		[[Category: Rizo, J]]
	[[Category: Sukumar, M.]]		[[Category: Sukumar, M]]
	[[Category: Wall, M.]]		[[Category: Wall, M]]
	[[Category: Disulfide]]		[[Category: Disulfide]]
	[[Category: Enterotoxin]]		[[Category: Enterotoxin]]
	[[Category: Heat-stable]]		[[Category: Heat-stable]]

OCA at 11:26, 24 September 2014

2014-09-24T11:26:38Z

← Older revision		Revision as of 11:26, 24 September 2014
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	[[~~Image~~:1ehs.~~png\|left\|200px~~]]		==THE STRUCTURE OF ESCHERICHIA COLI HEAT-STABLE ENTEROTOXIN B BY NUCLEAR MAGNETIC RESONANCE AND CIRCULAR DICHROISM==
			<StructureSection load='1ehs' size='340' side='right' caption='[[1ehs]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1ehs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EHS FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ehs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ehs RCSB], [http://www.ebi.ac.uk/pdbsum/1ehs PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The heat-stable enterotoxin b (STb) is secreted by enterotoxigenic Escherichia coli that cause secretory diarrhea in animals and humans. It is a 48-amino acid peptide containing two disulfide bridges, between residues 10 and 48 and 21 and 36, which are crucial for its biological activity. Here, we report the solution structure of STb determined by two- and three-dimensional NMR methods. Approximate interproton distances derived from NOE data were used to construct structures of STb using distance-geometry and simulated annealing procedures. The NMR-derived structure shows that STb is helical between residues 10 and 22 and residues 38 and 44. The helical structure in the region 10-22 is amphipathic and exposes several polar residues to the solvent, some of which have been shown to be important in determining the toxicity of STb. The hydrophobic residues on the opposite face of this helix make contacts with the hydrophobic residues of the C-terminal helix. The loop region between residues 21 and 36 has another cluster of hydrophobic residues and exposes Arg 29 and Asp 30, which have been shown to be important for intestinal secretory activity. CD studies show that reduction of disulfide bridges results in a dramatic loss of structure, which correlates with loss of function. Reduced STb adopts a predominantly random-coil conformation. Chromatographic measurements of concentrations of native, fully reduced, and single-disulfide species in equilibrium mixtures of STb in redox buffers indicate that the formation of the two disulfide bonds in STb is only moderately cooperative. Similar measurements in the presence of 8 M urea suggest that the native secondary structure significantly stabilizes the disulfide bonds.

	~~{{STRUCTURE_1ehs\| PDB=1ehs \| SCENE= }}~~		The structure of Escherichia coli heat-stable enterotoxin b by nuclear magnetic resonance and circular dichroism.,Sukumar M, Rizo J, Wall M, Dreyfus LA, Kupersztoch YM, Gierasch LM Protein Sci. 1995 Sep;4(9):1718-29. PMID:8528070<ref>PMID:8528070</ref>

	~~===THE STRUCTURE OF ESCHERICHIA COLI HEAT-STABLE ENTEROTOXIN B BY NUCLEAR MAGNETIC RESONANCE AND CIRCULAR DICHROISM===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			== References ==
	==~~About this Structure~~==		<references/>
	~~[[1ehs]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHS OCA].~~		__TOC__
			</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Dreyfus, L A.]]		[[Category: Dreyfus, L A.]]