1guy - Revision history

OCA at 12:07, 13 December 2023

2023-12-13T12:07:35Z

← Older revision		Revision as of 12:07, 13 December 2023
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	<StructureSection load='1guy' size='340' side='right'caption='[[1guy]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1guy' size='340' side='right'caption='[[1guy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1guy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_29366 Atcc 29366~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GUY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1guy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chloroflexus_aurantiacus Chloroflexus aurantiacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GUY FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>~~, ~~<scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1guz\|1guz]], [[1gv0\|1gv0]], [[1gv1\|1gv1]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Malate_dehydrogenase Malate dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.37 1.1.1.37]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1guy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1guy OCA], [https://pdbe.org/1guy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1guy RCSB], [https://www.ebi.ac.uk/pdbsum/1guy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1guy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1guy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1guy OCA], [https://pdbe.org/1guy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1guy RCSB], [https://www.ebi.ac.uk/pdbsum/1guy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1guy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MDH_CHLAA MDH_CHLAA]] Catalyzes the reversible oxidation of malate to oxaloacetate.[HAMAP-Rule:MF_00487]		[https://www.uniprot.org/uniprot/MDH_CHLAA MDH_CHLAA] Catalyzes the reversible oxidation of malate to oxaloacetate.[HAMAP-Rule:MF_00487]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Atcc 29366~~]]		[[Category: Chloroflexus aurantiacus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Malate dehydrogenase]]~~		[[Category: Bjork A]]
	[[Category: Bjork, A]]		[[Category: Dalhus B]]
	[[Category: Dalhus, B]]		[[Category: Eklund H]]
	[[Category: Eklund, H]]		[[Category: Eklund P]]
	[[Category: Eklund, P]]		[[Category: Johansson K]]
	[[Category: Johansson, K]]		[[Category: Karlsson A]]
	[[Category: Karlsson, A]]		[[Category: Naterstad K]]
	[[Category: Naterstad, K]]		[[Category: Ramaswamy S]]
	[[Category: Ramaswamy, S]]		[[Category: Sarinen M]]
	[[Category: Sarinen, M]]		[[Category: Sauer UH]]
	[[Category: Sauer~~, U H~~]]		[[Category: Sirevag R]]
	[[Category: Sirevag, R]]		[[Category: Synstad B]]
	[[Category: Synstad, B]]
	~~[[Category: Dehydrogenase]]~~
	~~[[Category: Nad]]~~
	~~[[Category: Oxidoreductase]]~~
	~~[[Category: Tricarboxylic acid cycle~~]]

OCA at 11:28, 28 July 2021

2021-07-28T11:28:57Z

← Older revision		Revision as of 11:28, 28 July 2021
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	<StructureSection load='1guy' size='340' side='right'caption='[[1guy]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1guy' size='340' side='right'caption='[[1guy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1guy]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_29366 Atcc 29366]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1GUY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1guy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_29366 Atcc 29366]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GUY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1guz\|1guz]], [[1gv0\|1gv0]], [[1gv1\|1gv1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1guz\|1guz]], [[1gv0\|1gv0]], [[1gv1\|1gv1]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Malate_dehydrogenase Malate dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.37 1.1.1.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Malate_dehydrogenase Malate dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.37 1.1.1.37] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1guy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1guy OCA], [~~http~~://pdbe.org/1guy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1guy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1guy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1guy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1guy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1guy OCA], [https://pdbe.org/1guy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1guy RCSB], [https://www.ebi.ac.uk/pdbsum/1guy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1guy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MDH_CHLAA MDH_CHLAA]] Catalyzes the reversible oxidation of malate to oxaloacetate.[HAMAP-Rule:MF_00487]		[[https://www.uniprot.org/uniprot/MDH_CHLAA MDH_CHLAA]] Catalyzes the reversible oxidation of malate to oxaloacetate.[HAMAP-Rule:MF_00487]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Malate ~~dehydrogenase~~\|Malate ~~dehydrogenase~~]]		*[[Malate Dehydrogenase 3D structures\|Malate Dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:07, 23 October 2019

2019-10-23T09:07:03Z

← Older revision		Revision as of 09:07, 23 October 2019
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	==Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases==		==Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases==
	<StructureSection load='1guy' size='340' side='right' caption='[[1guy]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1guy' size='340' side='right'caption='[[1guy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1guy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29366 Atcc 29366]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GUY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1guy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29366 Atcc 29366]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GUY FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 1guy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1guy" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Malate dehydrogenase\|Malate dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 29366]]		[[Category: Atcc 29366]]
			[[Category: Large Structures]]
	[[Category: Malate dehydrogenase]]		[[Category: Malate dehydrogenase]]
	[[Category: Bjork, A]]		[[Category: Bjork, A]]

OCA at 06:45, 3 January 2018

2018-01-03T06:45:57Z

← Older revision		Revision as of 06:45, 3 January 2018
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	==~~STRUCTURAL BASIS FOR THERMOPHILIC PROTEIN STABILITY~~: ~~STRUCTURES OF THERMOPHILIC AND MESOPHILIC MALATE DEHYDROGENASES~~==
			==Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases==
	<StructureSection load='1guy' size='340' side='right' caption='[[1guy]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1guy' size='340' side='right' caption='[[1guy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1guz\|1guz]], [[1gv0\|1gv0]], [[1gv1\|1gv1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1guz\|1guz]], [[1gv0\|1gv0]], [[1gv1\|1gv1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Malate_dehydrogenase Malate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.37 1.1.1.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Malate_dehydrogenase Malate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.37 1.1.1.37] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1guy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1guy OCA], [http://pdbe.org/1guy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1guy RCSB], [http://www.ebi.ac.uk/pdbsum/1guy PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1guy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1guy OCA], [http://pdbe.org/1guy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1guy RCSB], [http://www.ebi.ac.uk/pdbsum/1guy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1guy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gu/1guy_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gu/1guy_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 1guy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1guy" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Malate dehydrogenase\|Malate dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:11, 9 February 2016

2016-02-09T10:11:24Z

← Older revision		Revision as of 10:11, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1guy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:12, 10 September 2015

2015-09-10T21:12:59Z

← Older revision		Revision as of 21:12, 10 September 2015
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	<StructureSection load='1guy' size='340' side='right' caption='[[1guy]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1guy' size='340' side='right' caption='[[1guy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1guy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Chloroflexus_aurantiacus Chloroflexus aurantiacus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GUY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1guy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29366 Atcc 29366]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GUY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1guz\|1guz]], [[1gv0\|1gv0]], [[1gv1\|1gv1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1guz\|1guz]], [[1gv0\|1gv0]], [[1gv1\|1gv1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Malate_dehydrogenase Malate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.37 1.1.1.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Malate_dehydrogenase Malate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.37 1.1.1.37] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1guy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1guy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1guy RCSB], [http://www.ebi.ac.uk/pdbsum/1guy PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1guy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1guy OCA], [http://pdbe.org/1guy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1guy RCSB], [http://www.ebi.ac.uk/pdbsum/1guy PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1guy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Chloroflexus aurantiacus~~]]		[[Category: Atcc 29366]]
	[[Category: Malate dehydrogenase]]		[[Category: Malate dehydrogenase]]
	[[Category: Bjork, A]]		[[Category: Bjork, A]]

OCA at 06:10, 25 December 2014

2014-12-25T06:10:46Z

← Older revision		Revision as of 06:10, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1guy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1guy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1guy RCSB], [http://www.ebi.ac.uk/pdbsum/1guy PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1guy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1guy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1guy RCSB], [http://www.ebi.ac.uk/pdbsum/1guy PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MDH_CHLAA MDH_CHLAA]] Catalyzes the reversible oxidation of malate to oxaloacetate.[HAMAP-Rule:MF_00487]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 23:54, 22 December 2014

2014-12-22T23:54:21Z

← Older revision		Revision as of 23:54, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1guy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chloroflexus_aurantiacus Chloroflexus aurantiacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GUY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1guy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chloroflexus_aurantiacus Chloroflexus aurantiacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GUY FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1guz\|1guz]], [[1gv0\|1gv0]], [[1gv1\|1gv1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1guz\|1guz]], [[1gv0\|1gv0]], [[1gv1\|1gv1]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Malate_dehydrogenase Malate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.37 1.1.1.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Malate_dehydrogenase Malate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.37 1.1.1.37] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1guy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1guy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1guy RCSB], [http://www.ebi.ac.uk/pdbsum/1guy PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1guy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1guy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1guy RCSB], [http://www.ebi.ac.uk/pdbsum/1guy PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Chloroflexus aurantiacus]]		[[Category: Chloroflexus aurantiacus]]
	[[Category: Malate dehydrogenase]]		[[Category: Malate dehydrogenase]]
	[[Category: Bjork, A.]]		[[Category: Bjork, A]]
	[[Category: Dalhus, B.]]		[[Category: Dalhus, B]]
	[[Category: Eklund, H.]]		[[Category: Eklund, H]]
	[[Category: Eklund, P.]]		[[Category: Eklund, P]]
	[[Category: Johansson, K.]]		[[Category: Johansson, K]]
	[[Category: Karlsson, A.]]		[[Category: Karlsson, A]]
	[[Category: Naterstad, K.]]		[[Category: Naterstad, K]]
	[[Category: Ramaswamy, S.]]		[[Category: Ramaswamy, S]]
	[[Category: Sarinen, M.]]		[[Category: Sarinen, M]]
	[[Category: Sauer, U H.]]		[[Category: Sauer, U H]]
	[[Category: Sirevag, R.]]		[[Category: Sirevag, R]]
	[[Category: Synstad, B.]]		[[Category: Synstad, B]]
	[[Category: Dehydrogenase]]		[[Category: Dehydrogenase]]
	[[Category: Nad]]		[[Category: Nad]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Tricarboxylic acid cycle]]		[[Category: Tricarboxylic acid cycle]]

OCA at 05:34, 3 October 2014

2014-10-03T05:34:48Z

← Older revision		Revision as of 05:34, 3 October 2014
Line 1:		Line 1:
	[[Image:~~1guy~~.~~png~~\|~~left~~\|~~200px~~]]		==STRUCTURAL BASIS FOR THERMOPHILIC PROTEIN STABILITY: STRUCTURES OF THERMOPHILIC AND MESOPHILIC MALATE DEHYDROGENASES==
			<StructureSection load='1guy' size='340' side='right' caption='[[1guy]], [[Resolution\|resolution]] 2.20Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1guy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chloroflexus_aurantiacus Chloroflexus aurantiacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GUY FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1guz\|1guz]], [[1gv0\|1gv0]], [[1gv1\|1gv1]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Malate_dehydrogenase Malate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.37 1.1.1.37] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1guy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1guy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1guy RCSB], [http://www.ebi.ac.uk/pdbsum/1guy PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gu/1guy_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The three-dimensional structure of four malate dehydrogenases (MDH) from thermophilic and mesophilic phototropic bacteria have been determined by X-ray crystallography and the corresponding structures compared. In contrast to the dimeric quaternary structure of most MDHs, these MDHs are tetramers and are structurally related to tetrameric malate dehydrogenases from Archaea and to lactate dehydrogenases. The tetramers are dimers of dimers, where the structures of each subunit and the dimers are similar to the dimeric malate dehydrogenases. The difference in optimal growth temperature of the corresponding organisms is relatively small, ranging from 32 to 55 degrees C. Nevertheless, on the basis of the four crystal structures, a number of factors that are likely to contribute to the relative thermostability in the present series have been identified. It appears from the results obtained, that the difference in thermostability between MDH from the mesophilic Chlorobium vibrioforme on one hand and from the moderate thermophile Chlorobium tepidum on the other hand is mainly due to the presence of polar residues that form additional hydrogen bonds within each subunit. Furthermore, for the even more thermostable Chloroflexus aurantiacus MDH, the use of charged residues to form additional ionic interactions across the dimer-dimer interface is favored. This enzyme has a favorable intercalation of His-Trp as well as additional aromatic contacts at the monomer-monomer interface in each dimer. A structural alignment of tetrameric and dimeric prokaryotic MDHs reveal that structural elements that differ among dimeric and tetrameric MDHs are located in a few loop regions.

	~~{{STRUCTURE_1guy\| PDB=1guy \| SCENE= }}~~		Structural basis for thermophilic protein stability: structures of thermophilic and mesophilic malate dehydrogenases.,Dalhus B, Saarinen M, Sauer UH, Eklund P, Johansson K, Karlsson A, Ramaswamy S, Bjork A, Synstad B, Naterstad K, Sirevag R, Eklund H J Mol Biol. 2002 May 3;318(3):707-21. PMID:12054817<ref>PMID:12054817</ref>

	~~===STRUCTURAL BASIS FOR THERMOPHILIC PROTEIN STABILITY: STRUCTURES OF THERMOPHILIC AND MESOPHILIC MALATE DEHYDROGENASES===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_12054817}}~~

	~~==About this Structure==~~
	~~[[1guy]] is~~ a ~~2 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Chloroflexus_aurantiacus Chloroflexus aurantiacus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=1GUY OCA].~~

	==See Also==		==See Also==
	*[[Johnson sandbox 1\|Johnson sandbox 1]]
	*[[Malate dehydrogenase\|Malate dehydrogenase]]		*[[Malate dehydrogenase\|Malate dehydrogenase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:012054817<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Chloroflexus aurantiacus]]		[[Category: Chloroflexus aurantiacus]]
	[[Category: Malate dehydrogenase]]		[[Category: Malate dehydrogenase]]

OCA at 13:31, 20 October 2012

2012-10-20T13:31:52Z

← Older revision		Revision as of 13:31, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[1guy]] is a 2 chain structure ~~of [[Johnson sandbox 1]] and [[Malate dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Chloroflexus_aurantiacus Chloroflexus aurantiacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUY OCA].		[[1guy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chloroflexus_aurantiacus Chloroflexus aurantiacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUY OCA].

	==See Also==		==See Also==