1htm - Revision history

OCA at 05:29, 5 June 2024

2024-06-05T05:29:54Z

← Older revision		Revision as of 05:29, 5 June 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1htm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Uncultured_beta_proteobacterium_UMTRA-608 Uncultured beta proteobacterium UMTRA-608]. The April 2006 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HTM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1htm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Uncultured_beta_proteobacterium_UMTRA-608 Uncultured beta proteobacterium UMTRA-608]. The April 2006 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HTM FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [https://pdbe.org/1htm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB], [https://www.ebi.ac.uk/pdbsum/1htm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1htm ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [https://pdbe.org/1htm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB], [https://www.ebi.ac.uk/pdbsum/1htm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1htm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:03, 11 January 2023

2023-01-11T08:03:34Z

← Older revision		Revision as of 08:03, 11 January 2023
Line 3:		Line 3:
	<StructureSection load='1htm' size='340' side='right'caption='[[1htm]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1htm' size='340' side='right'caption='[[1htm]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1htm]] is a 6 chain structure. The April 2006 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HTM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1htm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Uncultured_beta_proteobacterium_UMTRA-608 Uncultured beta proteobacterium UMTRA-608]. The April 2006 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HTM FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [https://pdbe.org/1htm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB], [https://www.ebi.ac.uk/pdbsum/1htm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1htm ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [https://pdbe.org/1htm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB], [https://www.ebi.ac.uk/pdbsum/1htm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1htm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/HEMA_I68A0 HEMA_I68A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.		[https://www.uniprot.org/uniprot/HEMA_I68A0 HEMA_I68A0] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: ~~Bullough, P A~~]]		[[Category: Uncultured beta proteobacterium UMTRA-608]]
	[[Category: ~~Hughson, F M~~]]		[[Category: Bullough PA]]
	[[Category: ~~Skehel, J J~~]]		[[Category: Hughson FM]]
	[[Category: ~~Wiley, D C~~]]		[[Category: Skehel JJ]]
	[[Category: ~~Influenza virus hemagglutinin]]~~		[[Category: Wiley DC]]
	~~[[Category: Viral protein~~]]

OCA at 07:28, 7 April 2021

2021-04-07T07:28:03Z

← Older revision		Revision as of 07:28, 7 April 2021
Line 3:		Line 3:
	<StructureSection load='1htm' size='340' side='right'caption='[[1htm]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1htm' size='340' side='right'caption='[[1htm]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1htm]] is a 6 chain structure. The April 2006 RCSB PDB [~~http~~://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [~~http~~://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1HTM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1htm]] is a 6 chain structure. The April 2006 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HTM FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [~~http~~://pdbe.org/1htm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1htm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1htm ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [https://pdbe.org/1htm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB], [https://www.ebi.ac.uk/pdbsum/1htm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1htm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/HEMA_I68A0 HEMA_I68A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.		[[https://www.uniprot.org/uniprot/HEMA_I68A0 HEMA_I68A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:

	==See Also==		==See Also==
	*[[Hemagglutinin\|Hemagglutinin]]		*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:22, 3 July 2019

2019-07-03T07:22:45Z

← Older revision		Revision as of 07:22, 3 July 2019
Line 1:		Line 1:

	==STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION==		==STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION==
	<StructureSection load='1htm' size='340' side='right' caption='[[1htm]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1htm' size='340' side='right'caption='[[1htm]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1htm]] is a 6 chain structure. The April 2006 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HTM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1htm]] is a 6 chain structure. The April 2006 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HTM FirstGlance]. <br>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Hemagglutinin]]		[[Category: Hemagglutinin]]
			[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Bullough, P A]]		[[Category: Bullough, P A]]

OCA at 10:48, 27 September 2017

2017-09-27T10:48:31Z

← Older revision		Revision as of 10:48, 27 September 2017
Line 1:		Line 1:

	==STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION==		==STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION==
	<StructureSection load='1htm' size='340' side='right' caption='[[1htm]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1htm' size='340' side='right' caption='[[1htm]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1htm]] is a 6 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Uncultured_beta_proteobacterium_umtra-608 Uncultured beta proteobacterium umtra-608]~~. The April 2006 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HTM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1htm]] is a 6 chain structure. The April 2006 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HTM FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [http://pdbe.org/1htm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB], [http://www.ebi.ac.uk/pdbsum/1htm PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [http://pdbe.org/1htm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB], [http://www.ebi.ac.uk/pdbsum/1htm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1htm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 26:
	[[Category: Hemagglutinin]]		[[Category: Hemagglutinin]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	~~[[Category: Uncultured beta proteobacterium umtra-608]]~~
	[[Category: Bullough, P A]]		[[Category: Bullough, P A]]
	[[Category: Hughson, F M]]		[[Category: Hughson, F M]]

OCA at 14:50, 10 September 2015

2015-09-10T14:50:03Z

← Older revision		Revision as of 14:50, 10 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1htm]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Uncultured_beta_proteobacterium_umtra-608 Uncultured beta proteobacterium umtra-608]. The April 2006 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HTM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1htm]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Uncultured_beta_proteobacterium_umtra-608 Uncultured beta proteobacterium umtra-608]. The April 2006 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HTM FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB], [http://www.ebi.ac.uk/pdbsum/1htm PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [http://pdbe.org/1htm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB], [http://www.ebi.ac.uk/pdbsum/1htm PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1htm" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 01:45, 25 December 2014

2014-12-25T01:45:41Z

← Older revision		Revision as of 01:45, 25 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB], [http://www.ebi.ac.uk/pdbsum/1htm PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB], [http://www.ebi.ac.uk/pdbsum/1htm PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/HEMA_I68A0 HEMA_I68A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:05, 17 December 2014

2014-12-17T14:05:11Z

← Older revision		Revision as of 14:05, 17 December 2014
Line 1:		Line 1:
	~~{{STRUCTURE_1htm\| PDB=1htm \| SCENE= }}~~		==STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION==
	===STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION===		<StructureSection load='1htm' size='340' side='right' caption='[[1htm]], [[Resolution\|resolution]] 2.50Å' scene=''>
	~~{{ABSTRACT_PUBMED_8072525}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[1htm]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Uncultured_beta_proteobacterium_umtra-608 Uncultured beta proteobacterium umtra-608]. The April 2006 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HTM FirstGlance]. <br>
			</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB], [http://www.ebi.ac.uk/pdbsum/1htm PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 A to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered.

	~~==About this~~ Structure==		Structure of influenza haemagglutinin at the pH of membrane fusion.,Bullough PA, Hughson FM, Skehel JJ, Wiley DC Nature. 1994 Sep 1;371(6492):37-43. PMID:8072525<ref>PMID:8072525</ref>
	~~[[1htm]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Uncultured_beta_proteobacterium_umtra-608 Uncultured beta proteobacterium umtra~~-~~608]~~. ~~The April 2006 RCSB PDB [http~~://~~pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule~~ of the ~~Month] feature on ''Hemagglutinin'' by David~~ S. ~~Goodsell is [http://dx~~.~~doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin~~/~~ocashort?id=1HTM OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
	*[[Hemagglutinin\|Hemagglutinin]]		*[[Hemagglutinin\|Hemagglutinin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:008072525<~~/~~ref~~><~~ref group="xtra">PMID:015298055</ref><references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Hemagglutinin]]		[[Category: Hemagglutinin]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Uncultured beta proteobacterium umtra-608]]		[[Category: Uncultured beta proteobacterium umtra-608]]
	[[Category: Bullough, P A.]]		[[Category: Bullough, P A]]
	[[Category: Hughson, F M.]]		[[Category: Hughson, F M]]
	[[Category: Skehel, J J.]]		[[Category: Skehel, J J]]
	[[Category: Wiley, D C.]]		[[Category: Wiley, D C]]
	[[Category: Influenza virus hemagglutinin]]		[[Category: Influenza virus hemagglutinin]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 10:20, 11 March 2013

2013-03-11T10:20:51Z

← Older revision		Revision as of 10:20, 11 March 2013
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	~~[[Image:1htm.png\|left\|200px]]~~

	{{STRUCTURE_1htm\| PDB=1htm \| SCENE= }}		{{STRUCTURE_1htm\| PDB=1htm \| SCENE= }}

	===STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION===		===STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION===

	{{ABSTRACT_PUBMED_8072525}}		{{ABSTRACT_PUBMED_8072525}}

OCA at 11:17, 20 October 2012

2012-10-20T11:17:21Z

← Older revision		Revision as of 11:17, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[1htm]] is a 6 chain structure ~~of [[Hemagglutinin]]~~ with sequence from [http://en.wikipedia.org/wiki/~~Bacteria Bacteria~~]. The April 2006 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA].		[[1htm]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Uncultured_beta_proteobacterium_umtra-608 Uncultured beta proteobacterium umtra-608]. The April 2006 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Hemagglutinin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2006_4 10.2210/rcsb_pdb/mom_2006_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA].

	==See Also==		==See Also==
Line 15:		Line 15:
	==Reference==		==Reference==
	<ref group="xtra">PMID:008072525</ref><ref group="xtra">PMID:015298055</ref><references group="xtra"/>		<ref group="xtra">PMID:008072525</ref><ref group="xtra">PMID:015298055</ref><references group="xtra"/>
	~~[[Category: Bacteria]]~~
	[[Category: Hemagglutinin]]		[[Category: Hemagglutinin]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
			[[Category: Uncultured beta proteobacterium umtra-608]]
	[[Category: Bullough, P A.]]		[[Category: Bullough, P A.]]
	[[Category: Hughson, F M.]]		[[Category: Hughson, F M.]]