1ji9 - Revision history

OCA at 18:43, 29 November 2023

2023-11-29T18:43:19Z

← Older revision		Revision as of 18:43, 29 November 2023
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	==Solution structure of the alpha-domain of mouse metallothionein-3==		==Solution structure of the alpha-domain of mouse metallothionein-3==
	<StructureSection load='1ji9' size='340' side='right'caption='[[1ji9~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>		<StructureSection load='1ji9' size='340' side='right'caption='[[1ji9]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ji9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JI9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ji9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JI9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ji9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji9 OCA], [https://pdbe.org/1ji9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ji9 RCSB], [https://www.ebi.ac.uk/pdbsum/1ji9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ji9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ji9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji9 OCA], [https://pdbe.org/1ji9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ji9 RCSB], [https://www.ebi.ac.uk/pdbsum/1ji9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ji9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MT3_MOUSE MT3_MOUSE]] Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity).		[https://www.uniprot.org/uniprot/MT3_MOUSE MT3_MOUSE] Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: Armitage~~, I M~~]]		[[Category: Armitage IM]]
	[[Category: Oz, G]]		[[Category: Oz G]]
	[[Category: Zangger, K]]		[[Category: Zangger K]]
	~~[[Category: 3-10 helix]]~~
	~~[[Category: Cd-s cluster]]~~
	~~[[Category: Half turn]]~~
	~~[[Category: Metal binding protein]]~~
	~~[[Category: Type ii turn~~]]

OCA at 07:19, 14 April 2021

2021-04-14T07:19:17Z

← Older revision		Revision as of 07:19, 14 April 2021
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	<StructureSection load='1ji9' size='340' side='right'caption='[[1ji9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1ji9' size='340' side='right'caption='[[1ji9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ji9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JI9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ji9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JI9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ji9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji9 OCA], [~~http~~://pdbe.org/1ji9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ji9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ji9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ji9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ji9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji9 OCA], [https://pdbe.org/1ji9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ji9 RCSB], [https://www.ebi.ac.uk/pdbsum/1ji9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ji9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MT3_MOUSE MT3_MOUSE]] Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity).		[[https://www.uniprot.org/uniprot/MT3_MOUSE MT3_MOUSE]] Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:59, 10 July 2019

2019-07-10T06:59:11Z

← Older revision		Revision as of 06:59, 10 July 2019
Line 1:		Line 1:

	==Solution structure of the alpha-domain of mouse metallothionein-3==		==Solution structure of the alpha-domain of mouse metallothionein-3==
	<StructureSection load='1ji9' size='340' side='right' caption='[[1ji9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1ji9' size='340' side='right'caption='[[1ji9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ji9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JI9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ji9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JI9 FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Armitage, I M]]		[[Category: Armitage, I M]]

OCA at 09:50, 4 October 2017

2017-10-04T09:50:03Z

← Older revision		Revision as of 09:50, 4 October 2017
Line 1:		Line 1:

	==Solution structure of the alpha-domain of mouse metallothionein-3==		==Solution structure of the alpha-domain of mouse metallothionein-3==
	<StructureSection load='1ji9' size='340' side='right' caption='[[1ji9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1ji9' size='340' side='right' caption='[[1ji9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1ji9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JI9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ji9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JI9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ji9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji9 OCA], [http://pdbe.org/1ji9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ji9 RCSB], [http://www.ebi.ac.uk/pdbsum/1ji9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ji9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji9 OCA], [http://pdbe.org/1ji9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ji9 RCSB], [http://www.ebi.ac.uk/pdbsum/1ji9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ji9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:17, 11 September 2015

2015-09-11T11:17:57Z

← Older revision		Revision as of 11:17, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1ji9' size='340' side='right' caption='[[1ji9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1ji9' size='340' side='right' caption='[[1ji9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ji9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JI9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ji9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JI9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ji9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ji9 RCSB], [http://www.ebi.ac.uk/pdbsum/1ji9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ji9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji9 OCA], [http://pdbe.org/1ji9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ji9 RCSB], [http://www.ebi.ac.uk/pdbsum/1ji9 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1ji9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Mus musculus~~]]		[[Category: Lk3 transgenic mice]]
	[[Category: Armitage, I M]]		[[Category: Armitage, I M]]
	[[Category: Oz, G]]		[[Category: Oz, G]]

OCA at 15:43, 25 December 2014

2014-12-25T15:43:44Z

← Older revision		Revision as of 15:43, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ji9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ji9 RCSB], [http://www.ebi.ac.uk/pdbsum/1ji9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ji9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ji9 RCSB], [http://www.ebi.ac.uk/pdbsum/1ji9 PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MT3_MOUSE MT3_MOUSE]] Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:02, 22 December 2014

2014-12-22T06:02:58Z

← Older revision		Revision as of 06:02, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ji9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JI9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ji9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JI9 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ji9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ji9 RCSB], [http://www.ebi.ac.uk/pdbsum/1ji9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ji9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ji9 RCSB], [http://www.ebi.ac.uk/pdbsum/1ji9 PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Armitage, I M.]]		[[Category: Armitage, I M]]
	[[Category: Oz, G.]]		[[Category: Oz, G]]
	[[Category: Zangger, K.]]		[[Category: Zangger, K]]
	[[Category: 3-10 helix]]		[[Category: 3-10 helix]]
	[[Category: Cd-s cluster]]		[[Category: Cd-s cluster]]

OCA at 05:44, 8 June 2014

2014-06-08T05:44:29Z

← Older revision		Revision as of 05:44, 8 June 2014
Line 1:		Line 1:
	[[~~Image~~:1ji9.~~png\|left\|200px~~]]		==Solution structure of the alpha-domain of mouse metallothionein-3==
			<StructureSection load='1ji9' size='340' side='right' caption='[[1ji9]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1ji9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JI9 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ji9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ji9 RCSB], [http://www.ebi.ac.uk/pdbsum/1ji9 PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The brain specific member of the metallothionein (MT) family of proteins, metallothionein-3, inhibits the growth and survival of neurons, in contrast to the ubiquitous mammalian MT isoforms, MT-1 and MT-2, that are found in most tissues and are thought to function in metal ion homeostasis and detoxification. Solution NMR was utilized to determine the structural and dynamic differences of MT-3 from MT-1 and 2. The high-resolution solution structure of the C-terminal alpha-domain of recombinant mouse MT-3 revealed a tertiary fold very similar to MT-1 and 2, except for a loop that accommodates an acidic insertion relative to these isoforms. This loop was distinguished from the rest of the domain by dynamics of the backbone on the nano- to picosecond time-scale shown by (15)N relaxation studies and was identified as a possible interaction site with other proteins. The N-terminal beta-domain contains the region responsible for the growth inhibitory activity, a CPCP tetrapeptide close to the N-terminus. Because of exchange broadening of a large number of the NMR signals from this domain, homology modeling was utilized to calculate models for the beta-domain and suggested that while the backbone fold of the MT-3 beta-domain is identical to MT-1 and 2, the second proline responsible for the activity, Pro9, may show structural heterogeneity. (15)N relaxation analyses implied fast internal motions for the beta-domain. On the basis of these observations, we conclude that the growth inhibitory activity exhibited by MT-3 is a result of a combination of local structural differences and global dynamics in the beta-domain.

	~~{{STRUCTURE_1ji9\| PDB=1ji9 \| SCENE= }}~~		Three-dimensional structure and dynamics of a brain specific growth inhibitory factor: metallothionein-3.,Oz G, Zangger K, Armitage IM Biochemistry. 2001 Sep 25;40(38):11433-41. PMID:11560491<ref>PMID:11560491</ref>

	~~===Solution structure~~ of the ~~alpha-domain of mouse metallothionein-3===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_11560491}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[1ji9]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:011560491<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Armitage, I M.]]		[[Category: Armitage, I M.]]

OCA: Protected "1ji9" [edit=sysop:move=sysop]

2012-08-14T17:43:59Z

Protected "1ji9" [edit=sysop:move=sysop]

← Older revision	Revision as of 17:43, 14 August 2012
(No difference)

OCA at 17:43, 14 August 2012

2012-08-14T17:43:57Z

← Older revision		Revision as of 17:43, 14 August 2012
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	~~{{Seed}}~~
	[[Image:1ji9.png\|left\|200px]]		[[Image:1ji9.png\|left\|200px]]

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	{{STRUCTURE_1ji9\| PDB=1ji9 \| SCENE= }}		{{STRUCTURE_1ji9\| PDB=1ji9 \| SCENE= }}

	===Solution structure of the alpha-domain of mouse metallothionein-3===		===Solution structure of the alpha-domain of mouse metallothionein-3===


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	{{ABSTRACT_PUBMED_11560491}}		{{ABSTRACT_PUBMED_11560491}}

	==About this Structure==		==About this Structure==
	~~1JI9 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA].		[[1ji9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI9 OCA].

	==Reference==		==Reference==
	~~Three-dimensional structure and dynamics of a brain specific growth inhibitory factor: metallothionein-3., Oz G, Zangger K, Armitage IM, Biochemistry. 2001 Sep 25;40(38):11433-41.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~11560491 11560491]~~		<ref group="xtra">PMID:011560491</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	~~[[Category: Single protein]]~~
	[[Category: Armitage, I M.]]		[[Category: Armitage, I M.]]
	[[Category: Oz, G.]]		[[Category: Oz, G.]]
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	[[Category: Cd-s cluster]]		[[Category: Cd-s cluster]]
	[[Category: Half turn]]		[[Category: Half turn]]
			[[Category: Metal binding protein]]
	[[Category: Type ii turn]]		[[Category: Type ii turn]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:17:15 2008''~~