1jun - Revision history

OCA at 07:28, 23 October 2024

2024-10-23T07:28:32Z

← Older revision		Revision as of 07:28, 23 October 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jun]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JUN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jun]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JUN FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 7 models</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jun OCA], [https://pdbe.org/1jun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jun RCSB], [https://www.ebi.ac.uk/pdbsum/1jun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jun ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jun OCA], [https://pdbe.org/1jun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jun RCSB], [https://www.ebi.ac.uk/pdbsum/1jun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jun ProSAT]</span></td></tr>
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/1jun_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/1jun_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jun ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jun ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The solution structure of the c-Jun leucine zipper domain has been determined to high resolution using a new calculation protocol designed to handle highly ambiguous sets of interproton distance restraints. The domain comprises a coiled coil of parallel alpha-helices in which most of the hydrophobic residues are buried at the highly symmetrical dimer interface; this interface extends over 10 helical turns and is the most elongated protein domain solved to date using NMR methods. The backbone fold is very similar to that seen in crystal structures of the GCN4 and Jun-Fos leucine zippers; however, in contrast with these crystal structures, the Jun leucine zipper dimer appears to be devoid of favorable intermolecular electrostatic interactions. A polar asparagine residue, located at the dimer interface, forms the sole point of asymmetry in the structure; furthermore, the side chain of this residue is disordered due to motional averaging. This residue, which is highly conserved in the leucine zipper family of transcription factors, provides a destabilizing influence that is likely to facilitate the rapid exchange of zipper strands in vivo.

			High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer.,Junius FK, O'Donoghue SI, Nilges M, Weiss AS, King GF J Biol Chem. 1996 Jun 7;271(23):13663-7. PMID:8662824<ref>PMID:8662824</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 1jun" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:55, 3 April 2024

2024-04-03T07:55:03Z

← Older revision		Revision as of 07:55, 3 April 2024
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	==NMR STUDY OF C-JUN HOMODIMER==		==NMR STUDY OF C-JUN HOMODIMER==
	<StructureSection load='1jun' size='340' side='right'caption='[[1jun~~]], [[NMR_Ensembles_of_Models \| 7 NMR models~~]]' scene=''>		<StructureSection load='1jun' size='340' side='right'caption='[[1jun]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jun]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JUN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jun]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JUN FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jun OCA], [https://pdbe.org/1jun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jun RCSB], [https://www.ebi.ac.uk/pdbsum/1jun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jun ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jun OCA], [https://pdbe.org/1jun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jun RCSB], [https://www.ebi.ac.uk/pdbsum/1jun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jun ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/JUN_HUMAN JUN_HUMAN] Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.<ref>PMID:10995748</ref> <ref>PMID:17210646</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jun ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jun ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The solution structure of the c-Jun leucine zipper domain has been determined to high resolution using a new calculation protocol designed to handle highly ambiguous sets of interproton distance restraints. The domain comprises a coiled coil of parallel alpha-helices in which most of the hydrophobic residues are buried at the highly symmetrical dimer interface; this interface extends over 10 helical turns and is the most elongated protein domain solved to date using NMR methods. The backbone fold is very similar to that seen in crystal structures of the GCN4 and Jun-Fos leucine zippers; however, in contrast with these crystal structures, the Jun leucine zipper dimer appears to be devoid of favorable intermolecular electrostatic interactions. A polar asparagine residue, located at the dimer interface, forms the sole point of asymmetry in the structure; furthermore, the side chain of this residue is disordered due to motional averaging. This residue, which is highly conserved in the leucine zipper family of transcription factors, provides a destabilizing influence that is likely to facilitate the rapid exchange of zipper strands in vivo.

	High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer.,Junius FK, O'Donoghue SI, Nilges M, Weiss AS, King GF J Biol Chem. 1996 Jun 7;271(23):13663-7. PMID:8662824<ref>PMID:8662824</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 1jun" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==
Line 33:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Donoghue, S I.O]]~~		[[Category: Junius FK]]
	[[Category: Junius~~, F K~~]]		[[Category: King GF]]
	[[Category: King~~, G F~~]]		[[Category: Nilges M]]
	[[Category: Nilges, M]]		[[Category: O'Donoghue SI]]
	[[Category: ~~Dna-binding regulatory protein]]~~
	~~[[Category: Oncogene protein]]~~
	~~[[Category: Transcription activation]]~~
	~~[[Category: Transcription regulation~~]]

OCA at 08:43, 21 April 2021

2021-04-21T08:43:26Z

← Older revision		Revision as of 08:43, 21 April 2021
Line 3:		Line 3:
	<StructureSection load='1jun' size='340' side='right'caption='[[1jun]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='1jun' size='340' side='right'caption='[[1jun]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jun]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1JUN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jun]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JUN FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jun OCA], [~~http~~://pdbe.org/1jun PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1jun RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1jun PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1jun ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jun OCA], [https://pdbe.org/1jun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jun RCSB], [https://www.ebi.ac.uk/pdbsum/1jun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jun ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 12:59, 17 July 2019

2019-07-17T12:59:12Z

← Older revision		Revision as of 12:59, 17 July 2019
Line 1:		Line 1:

	==NMR STUDY OF C-JUN HOMODIMER==		==NMR STUDY OF C-JUN HOMODIMER==
	<StructureSection load='1jun' size='340' side='right' caption='[[1jun]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='1jun' size='340' side='right'caption='[[1jun]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jun]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jun]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUN FirstGlance]. <br>
Line 11:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/1jun_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/1jun_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1jun" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jun" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[C-JUN\|C-JUN]]
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Donoghue, S I.O]]		[[Category: Donoghue, S I.O]]
	[[Category: Junius, F K]]		[[Category: Junius, F K]]

OCA at 07:15, 11 October 2017

2017-10-11T07:15:47Z

← Older revision		Revision as of 07:15, 11 October 2017
Line 1:		Line 1:

	==NMR STUDY OF C-JUN HOMODIMER==		==NMR STUDY OF C-JUN HOMODIMER==
	<StructureSection load='1jun' size='340' side='right' caption='[[1jun]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='1jun' size='340' side='right' caption='[[1jun]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1jun]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jun]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUN FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jun OCA], [http://pdbe.org/1jun PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jun RCSB], [http://www.ebi.ac.uk/pdbsum/1jun PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jun OCA], [http://pdbe.org/1jun PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jun RCSB], [http://www.ebi.ac.uk/pdbsum/1jun PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jun ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jun ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1jun" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1jun" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[C-JUN\|C-JUN]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:49, 11 September 2015

2015-09-11T22:49:07Z

← Older revision		Revision as of 22:49, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1jun' size='340' side='right' caption='[[1jun]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>		<StructureSection load='1jun' size='340' side='right' caption='[[1jun]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jun]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jun]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUN FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jun OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jun RCSB], [http://www.ebi.ac.uk/pdbsum/1jun PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jun OCA], [http://pdbe.org/1jun PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jun RCSB], [http://www.ebi.ac.uk/pdbsum/1jun PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1jun" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Donoghue, S I.O]]		[[Category: Donoghue, S I.O]]
	[[Category: Junius, F K]]		[[Category: Junius, F K]]

OCA at 12:04, 2 January 2015

2015-01-02T12:04:24Z

← Older revision		Revision as of 12:04, 2 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1jun]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUN FirstGlance]. <br>		<table><tr><td colspan='2'>[[1jun]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUN FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jun OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jun RCSB], [http://www.ebi.ac.uk/pdbsum/1jun PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jun OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jun RCSB], [http://www.ebi.ac.uk/pdbsum/1jun PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Donoghue, S I.O.]]		[[Category: Donoghue, S I.O]]
	[[Category: Junius, F K.]]		[[Category: Junius, F K]]
	[[Category: King, G F.]]		[[Category: King, G F]]
	[[Category: Nilges, M.]]		[[Category: Nilges, M]]
	[[Category: Dna-binding regulatory protein]]		[[Category: Dna-binding regulatory protein]]
	[[Category: Oncogene protein]]		[[Category: Oncogene protein]]
	[[Category: Transcription activation]]		[[Category: Transcription activation]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

OCA at 10:49, 28 September 2014

2014-09-28T10:49:32Z

← Older revision		Revision as of 10:49, 28 September 2014
Line 1:		Line 1:
	[[Image:~~1jun~~.~~png~~\|~~left~~\|~~200px~~]]		==NMR STUDY OF C-JUN HOMODIMER==
			<StructureSection load='1jun' size='340' side='right' caption='[[1jun]], [[NMR_Ensembles_of_Models \| 7 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1jun]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUN FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jun OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jun RCSB], [http://www.ebi.ac.uk/pdbsum/1jun PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/1jun_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The solution structure of the c-Jun leucine zipper domain has been determined to high resolution using a new calculation protocol designed to handle highly ambiguous sets of interproton distance restraints. The domain comprises a coiled coil of parallel alpha-helices in which most of the hydrophobic residues are buried at the highly symmetrical dimer interface; this interface extends over 10 helical turns and is the most elongated protein domain solved to date using NMR methods. The backbone fold is very similar to that seen in crystal structures of the GCN4 and Jun-Fos leucine zippers; however, in contrast with these crystal structures, the Jun leucine zipper dimer appears to be devoid of favorable intermolecular electrostatic interactions. A polar asparagine residue, located at the dimer interface, forms the sole point of asymmetry in the structure; furthermore, the side chain of this residue is disordered due to motional averaging. This residue, which is highly conserved in the leucine zipper family of transcription factors, provides a destabilizing influence that is likely to facilitate the rapid exchange of zipper strands in vivo.

	~~{{STRUCTURE_1jun\| PDB=1jun \| SCENE= }}~~		High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer.,Junius FK, O'Donoghue SI, Nilges M, Weiss AS, King GF J Biol Chem. 1996 Jun 7;271(23):13663-7. PMID:8662824<ref>PMID:8662824</ref>

	~~===NMR STUDY OF C-JUN HOMODIMER===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_8662824}}~~

	~~==About this Structure==~~
	~~[[1jun]] is~~ a ~~2 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=1JUN OCA].~~

	==See Also==		==See Also==
	*[[C-JUN\|C-JUN]]		*[[C-JUN\|C-JUN]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:008662824<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Donoghue, S I.O.]]		[[Category: Donoghue, S I.O.]]

OCA at 21:07, 20 October 2012

2012-10-20T21:07:29Z

← Older revision		Revision as of 21:07, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[1jun]] is a 2 chain structure ~~of [[C-JUN]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA].		[[1jun]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUN OCA].

	==See Also==		==See Also==

OCA: Protected "1jun" [edit=sysop:move=sysop]

2012-07-27T12:39:45Z

Protected "1jun" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:39, 27 July 2012
(No difference)