1loo - Revision history

OCA at 07:17, 25 October 2023

2023-10-25T07:17:22Z

← Older revision		Revision as of 07:17, 25 October 2023
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	<StructureSection load='1loo' size='340' side='right'caption='[[1loo]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1loo' size='340' side='right'caption='[[1loo]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1loo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1LOO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1loo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LOO FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GTP:GUANOSINE~~-~~5-TRIPHOSPHATE'>GTP</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1j4b\|1j4b]], [[1iwe\|1iwe]], [[1lny\|1lny]], [[1lon\|1lon]]</div>~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ADSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10090 LK3 transgenic mice])</td~~><~~/tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1loo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loo OCA], [https://pdbe.org/1loo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1loo RCSB], [https://www.ebi.ac.uk/pdbsum/1loo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1loo ProSAT]</span></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1loo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loo OCA], [~~http~~://pdbe.org/1loo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1loo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1loo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1loo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/PURA1_MOUSE PURA1_MOUSE]] Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.<ref>PMID:12482871</ref>		[https://www.uniprot.org/uniprot/PURA1_MOUSE PURA1_MOUSE] Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.<ref>PMID:12482871</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Adenylosuccinate synthetase 3D structures\|Adenylosuccinate synthetase 3D structures]]		*[[Adenylosuccinate synthetase 3D structures\|Adenylosuccinate synthetase 3D structures]]
	*[[User:Eric Martz/Entertaining PDB codes\|User:Eric Martz/Entertaining PDB codes]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Adenylosuccinate synthase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: Borza, T]]		[[Category: Borza T]]
	[[Category: Fromm~~, H J~~]]		[[Category: Fromm HJ]]
	[[Category: Honzatko~~, R B~~]]		[[Category: Honzatko RB]]
	[[Category: Iancu~~, C V]]~~		[[Category: Iancu CV]]
	~~[[Category: Gtp-binding]]~~
	~~[[Category: Ligase]]~~
	~~[[Category: Purine biosynthesis~~]]

OCA at 08:00, 25 November 2020

2020-11-25T08:00:37Z

← Older revision		Revision as of 08:00, 25 November 2020
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	==Crystal Structure of the Mouse-Muscle Adenylosuccinate Synthetase Ligated with GTP==		==Crystal Structure of the Mouse-Muscle Adenylosuccinate Synthetase Ligated with GTP==
	<StructureSection load='1loo' size='340' side='right' caption='[[1loo]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1loo' size='340' side='right'caption='[[1loo]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1loo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LOO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1loo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1LOO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j4b\|1j4b]], [[1iwe\|1iwe]], [[1lny\|1lny]], [[1lon\|1lon]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j4b\|1j4b]], [[1iwe\|1iwe]], [[1lny\|1lny]], [[1lon\|1lon]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1loo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loo OCA], [http://pdbe.org/1loo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1loo RCSB], [http://www.ebi.ac.uk/pdbsum/1loo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1loo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1loo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loo OCA], [http://pdbe.org/1loo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1loo RCSB], [http://www.ebi.ac.uk/pdbsum/1loo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1loo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1loo_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1loo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	==See Also==		==See Also==
			*[[Adenylosuccinate synthetase 3D structures\|Adenylosuccinate synthetase 3D structures]]
	*[[User:Eric Martz/Entertaining PDB codes\|User:Eric Martz/Entertaining PDB codes]]		*[[User:Eric Martz/Entertaining PDB codes\|User:Eric Martz/Entertaining PDB codes]]
	== References ==		== References ==
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	</StructureSection>		</StructureSection>
	[[Category: Adenylosuccinate synthase]]		[[Category: Adenylosuccinate synthase]]
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Borza, T]]		[[Category: Borza, T]]

OCA at 10:40, 12 October 2017

2017-10-12T10:40:08Z

← Older revision		Revision as of 10:40, 12 October 2017
Line 1:		Line 1:

	==Crystal Structure of the Mouse-Muscle Adenylosuccinate Synthetase Ligated with GTP==		==Crystal Structure of the Mouse-Muscle Adenylosuccinate Synthetase Ligated with GTP==
	<StructureSection load='1loo' size='340' side='right' caption='[[1loo]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1loo' size='340' side='right' caption='[[1loo]], [[Resolution\|resolution]] 2.20Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1loo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loo OCA], [http://pdbe.org/1loo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1loo RCSB], [http://www.ebi.ac.uk/pdbsum/1loo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1loo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loo OCA], [http://pdbe.org/1loo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1loo RCSB], [http://www.ebi.ac.uk/pdbsum/1loo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1loo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1loo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
	*[[~~Adenylosuccinate Synthetase~~\|~~Adenylosuccinate Synthetase~~]]		*[[User:Eric Martz/Entertaining PDB codes\|User:Eric Martz/Entertaining PDB codes]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:22, 11 September 2015

2015-09-11T08:22:09Z

← Older revision		Revision as of 08:22, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1loo' size='340' side='right' caption='[[1loo]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1loo' size='340' side='right' caption='[[1loo]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1loo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1loo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j4b\|1j4b]], [[1iwe\|1iwe]], [[1lny\|1lny]], [[1lon\|1lon]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j4b\|1j4b]], [[1iwe\|1iwe]], [[1lny\|1lny]], [[1lon\|1lon]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1loo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1loo RCSB], [http://www.ebi.ac.uk/pdbsum/1loo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1loo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loo OCA], [http://pdbe.org/1loo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1loo RCSB], [http://www.ebi.ac.uk/pdbsum/1loo PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1loo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	</StructureSection>		</StructureSection>
	[[Category: Adenylosuccinate synthase]]		[[Category: Adenylosuccinate synthase]]
	[[Category: ~~Mus musculus~~]]		[[Category: Lk3 transgenic mice]]
	[[Category: Borza, T]]		[[Category: Borza, T]]
	[[Category: Fromm, H J]]		[[Category: Fromm, H J]]

OCA at 13:47, 25 December 2014

2014-12-25T13:47:55Z

← Older revision		Revision as of 13:47, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1loo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1loo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOO FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j4b\|1j4b]], [[1iwe\|1iwe]], [[1lny\|1lny]], [[1lon\|1lon]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j4b\|1j4b]], [[1iwe\|1iwe]], [[1lny\|1lny]], [[1lon\|1lon]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1loo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1loo RCSB], [http://www.ebi.ac.uk/pdbsum/1loo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1loo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1loo RCSB], [http://www.ebi.ac.uk/pdbsum/1loo PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PURA1_MOUSE PURA1_MOUSE]] Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.<ref>PMID:12482871</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Adenylosuccinate synthase]]		[[Category: Adenylosuccinate synthase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Borza, T.]]		[[Category: Borza, T]]
	[[Category: Fromm, H J.]]		[[Category: Fromm, H J]]
	[[Category: Honzatko, R B.]]		[[Category: Honzatko, R B]]
	[[Category: Iancu, C V.]]		[[Category: Iancu, C V]]
	[[Category: Gtp-binding]]		[[Category: Gtp-binding]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Purine biosynthesis]]		[[Category: Purine biosynthesis]]

OCA at 15:58, 28 September 2014

2014-09-28T15:58:48Z

← Older revision		Revision as of 15:58, 28 September 2014
Line 1:		Line 1:
	[[Image:~~1loo~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal Structure of the Mouse-Muscle Adenylosuccinate Synthetase Ligated with GTP==
			<StructureSection load='1loo' size='340' side='right' caption='[[1loo]], [[Resolution\|resolution]] 2.20Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1loo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOO FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j4b\|1j4b]], [[1iwe\|1iwe]], [[1lny\|1lny]], [[1lon\|1lon]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1loo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1loo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1loo RCSB], [http://www.ebi.ac.uk/pdbsum/1loo PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1loo_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Prokaryotes have a single form of adenylosuccinate synthetase that controls the committed step of AMP biosynthesis, but vertebrates have two isozymes of the synthetase. The basic isozyme, which predominates in muscle, participates in the purine nucleotide cycle, has an active site conformation different from that of the Escherichia coli enzyme, and exhibits significant differences in ligand recognition. Crystalline complexes presented here of the recombinant basic isozyme from mouse show the following. GTP alone binds to the active site without inducing a conformational change. IMP in combination with an acetate anion induces major conformational changes and organizes the active site for catalysis. IMP, in the absence of GTP, binds to the GTP pocket of the synthetase. The combination of GTP and IMP results in the formation of a stable complex of 6-phosphoryl-IMP and GDP in the presence or absence of hadacidin. The response of the basic isozyme to GTP alone differs from that of synthetases from plants, and yet the conformation of the mouse basic and E. coli synthetases in their complexes with GDP, 6-phosphoryl-IMP, and hadacidin are nearly identical. Hence, reported differences in ligand recognition among synthetases probably arise from conformational variations observed in partially ligated enzymes.

	~~{{STRUCTURE_1loo\| PDB=1loo \| SCENE= }}~~		IMP, GTP, and 6-phosphoryl-IMP complexes of recombinant mouse muscle adenylosuccinate synthetase.,Iancu CV, Borza T, Fromm HJ, Honzatko RB J Biol Chem. 2002 Jul 26;277(30):26779-87. Epub 2002 May 9. PMID:12004071<ref>PMID:12004071</ref>

	~~===Crystal Structure~~ of the ~~Mouse-Muscle Adenylosuccinate Synthetase Ligated with GTP===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_12004071}}~~

	~~==About this Structure==~~
	~~[[1loo]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=1LOO OCA].~~

	==See Also==		==See Also==
	*[[Adenylosuccinate Synthetase\|Adenylosuccinate Synthetase]]		*[[Adenylosuccinate Synthetase\|Adenylosuccinate Synthetase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:012004071<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Adenylosuccinate synthase]]		[[Category: Adenylosuccinate synthase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 17:26, 20 October 2012

2012-10-20T17:26:14Z

← Older revision		Revision as of 17:26, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[1loo]] is a 1 chain structure ~~of [[Adenylosuccinate Synthetase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOO OCA].		[[1loo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOO OCA].

	==See Also==		==See Also==

OCA: Protected "1loo" [edit=sysop:move=sysop]

2012-07-27T00:52:52Z

Protected "1loo" [edit=sysop:move=sysop]

← Older revision	Revision as of 00:52, 27 July 2012
(No difference)

OCA at 00:52, 27 July 2012

2012-07-27T00:52:50Z

← Older revision		Revision as of 00:52, 27 July 2012
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:1loo.png\|left\|200px]]		[[Image:1loo.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_1loo", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_1loo\| PDB=1loo \| SCENE= }}		{{STRUCTURE_1loo\| PDB=1loo \| SCENE= }}

	===Crystal Structure of the Mouse-Muscle Adenylosuccinate Synthetase Ligated with GTP===		===Crystal Structure of the Mouse-Muscle Adenylosuccinate Synthetase Ligated with GTP===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_12004071}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 12004071 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_12004071}}		{{ABSTRACT_PUBMED_12004071}}

	==About this Structure==		==About this Structure==
	~~1LOO~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOO OCA].		[[1loo]] is a 1 chain structure of [[Adenylosuccinate Synthetase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOO OCA].

			==See Also==
			*[[Adenylosuccinate Synthetase\|Adenylosuccinate Synthetase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~12004071~~</ref><references group="xtra"/>		<ref group="xtra">PMID:012004071</ref><references group="xtra"/>
	[[Category: Adenylosuccinate synthase]]		[[Category: Adenylosuccinate synthase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
Line 33:		Line 24:
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Purine biosynthesis]]		[[Category: Purine biosynthesis]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:50:59 2009''~~

OCA at 15:51, 17 February 2009

2009-02-17T15:51:00Z

← Older revision		Revision as of 15:51, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	1LOO is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOO OCA].		1LOO is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOO OCA].

	==Reference==		==Reference==
	~~IMP, GTP, and 6-phosphoryl-IMP complexes of recombinant mouse muscle adenylosuccinate synthetase., Iancu CV, Borza T, Fromm HJ, Honzatko RB, J Biol Chem. 2002 Jul 26;277(30):26779-87. Epub 2002 May 9.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12004071 12004071]~~		<ref group="xtra">PMID:12004071</ref><references group="xtra"/>
	[[Category: Adenylosuccinate synthase]]		[[Category: Adenylosuccinate synthase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	~~[[Category: Single protein]]~~
	[[Category: Borza, T.]]		[[Category: Borza, T.]]
	[[Category: Fromm, H J.]]		[[Category: Fromm, H J.]]
Line 35:		Line 34:
	[[Category: Purine biosynthesis]]		[[Category: Purine biosynthesis]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 2 21~~:36:~~19 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:50:59 2009''