1o7b - Revision history

OCA at 08:55, 10 April 2024

2024-04-10T08:55:37Z

← Older revision		Revision as of 08:55, 10 April 2024
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	==Refined solution structure of the human TSG-6 Link module==		==Refined solution structure of the human TSG-6 Link module==
	<StructureSection load='1o7b' size='340' side='right'caption='[[1o7b~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='1o7b' size='340' side='right'caption='[[1o7b]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O7B FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O7B FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1tsg\|1tsg]], [[1o7c\|1o7c]]</div~~></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [https://pdbe.org/1o7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [https://www.ebi.ac.uk/pdbsum/1o7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [https://pdbe.org/1o7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [https://www.ebi.ac.uk/pdbsum/1o7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/TSG6_HUMAN TSG6_HUMAN]] Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.		[https://www.uniprot.org/uniprot/TSG6_HUMAN TSG6_HUMAN] Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o7b ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o7b ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The solution structure of the Link module from human TSG-6, a hyaladherin with important roles in inflammation and ovulation, has been determined in both its free and hyaluronan-bound conformations. This reveals a well defined hyaluronan-binding groove on one face of the Link module that is closed in the absence of ligand. The groove is lined with amino acids that have been implicated in mediating the interaction with hyaluronan, including two tyrosine residues that appear to form essential intermolecular hydrogen bonds and two basic residues capable of supporting ionic interactions. This is the first structure of a non-enzymic hyaladherin in its active state, and identifies a ligand-induced conformational change that is likely to be conserved across the Link module superfamily. NMR and isothermal titration calorimetry experiments with defined oligosaccharides have allowed us to infer the minimum length of hyaluronan that can be accommodated within the binding site and its polarity in the groove; these data have been used to generate a model of the complex formed between the Link module and a hyaluronan octasaccharide.

	The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding.,Blundell CD, Mahoney DJ, Almond A, DeAngelis PL, Kahmann JD, Teriete P, Pickford AR, Campbell ID, Day AJ J Biol Chem. 2003 Dec 5;278(49):49261-70. Epub 2003 Sep 11. PMID:12972412<ref>PMID:12972412</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 1o7b" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Blundell~~, C D~~]]		[[Category: Blundell CD]]
	[[Category: Campbell~~, I D~~]]		[[Category: Campbell ID]]
	[[Category: Day~~, A J~~]]		[[Category: Day AJ]]
	[[Category: Kahmann~~, J D~~]]		[[Category: Kahmann JD]]
	[[Category: Pickford~~, A R~~]]		[[Category: Pickford AR]]
	[[Category: Teriete, P]]		[[Category: Teriete P]]
	~~[[Category: Carbohydrate-binding domain]]~~
	~~[[Category: Cell adhesion]]~~
	~~[[Category: Glycoprotein]]~~
	~~[[Category: Hyaluronan-binding domain]]~~
	~~[[Category: Link module~~]]

OCA at 07:09, 25 August 2021

2021-08-25T07:09:25Z

← Older revision		Revision as of 07:09, 25 August 2021
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	<StructureSection load='1o7b' size='340' side='right'caption='[[1o7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1o7b' size='340' side='right'caption='[[1o7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1O7B FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O7B FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tsg\|1tsg]], [[1o7c\|1o7c]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tsg\|1tsg]], [[1o7c\|1o7c]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [~~http~~://pdbe.org/1o7b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1o7b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [https://pdbe.org/1o7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [https://www.ebi.ac.uk/pdbsum/1o7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/TSG6_HUMAN TSG6_HUMAN]] Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.		[[https://www.uniprot.org/uniprot/TSG6_HUMAN TSG6_HUMAN]] Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 18:19, 20 November 2019

2019-11-20T18:19:11Z

← Older revision		Revision as of 18:19, 20 November 2019
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	==Refined solution structure of the human TSG-6 Link module==		==Refined solution structure of the human TSG-6 Link module==
	<StructureSection load='1o7b' size='340' side='right' caption='[[1o7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1o7b' size='340' side='right'caption='[[1o7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7B FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7B FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Blundell, C D]]		[[Category: Blundell, C D]]
	[[Category: Campbell, I D]]		[[Category: Campbell, I D]]

OCA at 18:39, 24 January 2018

2018-01-24T18:39:04Z

← Older revision		Revision as of 18:39, 24 January 2018
Line 3:		Line 3:
	<StructureSection load='1o7b' size='340' side='right' caption='[[1o7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1o7b' size='340' side='right' caption='[[1o7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7B FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7B FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tsg\|1tsg]], [[1o7c\|1o7c]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tsg\|1tsg]], [[1o7c\|1o7c]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [http://pdbe.org/1o7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [http://www.ebi.ac.uk/pdbsum/1o7b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [http://pdbe.org/1o7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [http://www.ebi.ac.uk/pdbsum/1o7b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7b ProSAT]</span></td></tr>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/1o7b_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/1o7b_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Blundell, C D]]		[[Category: Blundell, C D]]
	[[Category: Campbell, I D]]		[[Category: Campbell, I D]]

OCA at 08:34, 3 August 2017

2017-08-03T08:34:39Z

← Older revision		Revision as of 08:34, 3 August 2017
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	==~~REFINED SOLUTION STRUCTURE OF THE HUMAN~~ TSG-6 ~~LINK MODULE~~==
			==Refined solution structure of the human TSG-6 Link module==
	<StructureSection load='1o7b' size='340' side='right' caption='[[1o7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1o7b' size='340' side='right' caption='[[1o7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7B FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7B FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tsg\|1tsg]], [[1o7c\|1o7c]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tsg\|1tsg]], [[1o7c\|1o7c]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [http://pdbe.org/1o7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [http://www.ebi.ac.uk/pdbsum/1o7b PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [http://pdbe.org/1o7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [http://www.ebi.ac.uk/pdbsum/1o7b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Human]]~~
	[[Category: Blundell, C D]]		[[Category: Blundell, C D]]
	[[Category: Campbell, I D]]		[[Category: Campbell, I D]]

OCA at 18:19, 7 February 2016

2016-02-07T18:19:54Z

← Older revision		Revision as of 18:19, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o7b ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:59, 10 September 2015

2015-09-10T03:59:17Z

← Older revision		Revision as of 03:59, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1o7b' size='340' side='right' caption='[[1o7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1o7b' size='340' side='right' caption='[[1o7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7B FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7B FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tsg\|1tsg]], [[1o7c\|1o7c]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tsg\|1tsg]], [[1o7c\|1o7c]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [http://www.ebi.ac.uk/pdbsum/1o7b PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [http://pdbe.org/1o7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [http://www.ebi.ac.uk/pdbsum/1o7b PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1o7b" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Blundell, C D]]		[[Category: Blundell, C D]]
	[[Category: Campbell, I D]]		[[Category: Campbell, I D]]

OCA at 17:23, 24 December 2014

2014-12-24T17:23:00Z

← Older revision		Revision as of 17:23, 24 December 2014
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7B FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7B FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tsg\|1tsg]], [[1o7c\|1o7c]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tsg\|1tsg]], [[1o7c\|1o7c]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [http://www.ebi.ac.uk/pdbsum/1o7b PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [http://www.ebi.ac.uk/pdbsum/1o7b PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/TSG6_HUMAN TSG6_HUMAN]] Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blundell, C D.]]		[[Category: Blundell, C D]]
	[[Category: Campbell, I D.]]		[[Category: Campbell, I D]]
	[[Category: Day, A J.]]		[[Category: Day, A J]]
	[[Category: Kahmann, J D.]]		[[Category: Kahmann, J D]]
	[[Category: Pickford, A R.]]		[[Category: Pickford, A R]]
	[[Category: Teriete, P.]]		[[Category: Teriete, P]]
	[[Category: Carbohydrate-binding domain]]		[[Category: Carbohydrate-binding domain]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 13:57, 29 September 2014

2014-09-29T13:57:36Z

← Older revision		Revision as of 13:57, 29 September 2014
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	[[Image:~~1o7b~~.~~png~~\|~~left~~\|~~200px~~]]		==REFINED SOLUTION STRUCTURE OF THE HUMAN TSG-6 LINK MODULE==
			<StructureSection load='1o7b' size='340' side='right' caption='[[1o7b]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1o7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7B FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tsg\|1tsg]], [[1o7c\|1o7c]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o7b RCSB], [http://www.ebi.ac.uk/pdbsum/1o7b PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/1o7b_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The solution structure of the Link module from human TSG-6, a hyaladherin with important roles in inflammation and ovulation, has been determined in both its free and hyaluronan-bound conformations. This reveals a well defined hyaluronan-binding groove on one face of the Link module that is closed in the absence of ligand. The groove is lined with amino acids that have been implicated in mediating the interaction with hyaluronan, including two tyrosine residues that appear to form essential intermolecular hydrogen bonds and two basic residues capable of supporting ionic interactions. This is the first structure of a non-enzymic hyaladherin in its active state, and identifies a ligand-induced conformational change that is likely to be conserved across the Link module superfamily. NMR and isothermal titration calorimetry experiments with defined oligosaccharides have allowed us to infer the minimum length of hyaluronan that can be accommodated within the binding site and its polarity in the groove; these data have been used to generate a model of the complex formed between the Link module and a hyaluronan octasaccharide.

	~~{{STRUCTURE_1o7b\| PDB=1o7b \| SCENE= }}~~		The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding.,Blundell CD, Mahoney DJ, Almond A, DeAngelis PL, Kahmann JD, Teriete P, Pickford AR, Campbell ID, Day AJ J Biol Chem. 2003 Dec 5;278(49):49261-70. Epub 2003 Sep 11. PMID:12972412<ref>PMID:12972412</ref>

	~~===REFINED SOLUTION STRUCTURE OF THE HUMAN TSG-6 LINK MODULE===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_12972412}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[1o7b]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes~~ the ~~now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1tsg 1tsg]. Full experimental information is available from [http://oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=1O7B OCA].~~		</StructureSection>

	~~==Reference==~~
	<~~ref group="xtra"~~>~~PMID:012972412~~</~~ref~~>~~<ref group~~=~~"xtra">PMID:012401803</ref><ref group~~=~~"xtra">PMID:012011075</ref><ref group~~=~~"xtra">PMID:011287417</ref><ref group~~=~~"xtra">PMID:010903951~~</~~ref~~><~~ref group="xtra">PMID:009126602</ref><ref group="xtra">PMID:008812829</ref><references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blundell, C D.]]		[[Category: Blundell, C D.]]

OCA at 09:38, 16 January 2013

2013-01-16T09:38:36Z

← Older revision		Revision as of 09:38, 16 January 2013
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	[[Image:1o7b.png\|left\|200px]]		[[Image:1o7b.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_1o7b", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_1o7b\| PDB=1o7b \| SCENE= }}		{{STRUCTURE_1o7b\| PDB=1o7b \| SCENE= }}

	===REFINED SOLUTION STRUCTURE OF THE HUMAN TSG-6 LINK MODULE===		===REFINED SOLUTION STRUCTURE OF THE HUMAN TSG-6 LINK MODULE===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_12972412}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 12972412 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_12972412}}		{{ABSTRACT_PUBMED_12972412}}

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	==Reference==		==Reference==
	<ref group="xtra">PMID:~~12972412~~</ref><ref group="xtra">PMID:~~12401803~~</ref><ref group="xtra">PMID:~~12011075~~</ref><ref group="xtra">PMID:~~11287417~~</ref><ref group="xtra">PMID:~~10903951~~</ref><ref group="xtra">PMID:~~9126602~~</ref><ref group="xtra">PMID:~~8812829</ref><ref group="xtra">PMID:8797823</ref><ref group="xtra">PMID:1730767~~</ref><references group="xtra"/>		<ref group="xtra">PMID:012972412</ref><ref group="xtra">PMID:012401803</ref><ref group="xtra">PMID:012011075</ref><ref group="xtra">PMID:011287417</ref><ref group="xtra">PMID:010903951</ref><ref group="xtra">PMID:009126602</ref><ref group="xtra">PMID:008812829</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blundell, C D.]]		[[Category: Blundell, C D.]]