1o7z - Revision history

OCA at 12:30, 13 December 2023

2023-12-13T12:30:13Z

← Older revision		Revision as of 12:30, 13 December 2023
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	<StructureSection load='1o7z' size='340' side='right'caption='[[1o7z]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='1o7z' size='340' side='right'caption='[[1o7z]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o7z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O7Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o7z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O7Z FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1lv9\|1lv9]]~~, [[~~1o7y~~\|~~1o7y~~]]~~, [[1o80\|1o80]]</div>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.92Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7z OCA], [https://pdbe.org/1o7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o7z RCSB], [https://www.ebi.ac.uk/pdbsum/1o7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7z OCA], [https://pdbe.org/1o7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o7z RCSB], [https://www.ebi.ac.uk/pdbsum/1o7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/CXL10_HUMAN CXL10_HUMAN]] Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.		[https://www.uniprot.org/uniprot/CXL10_HUMAN CXL10_HUMAN] Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Acharya~~, K R~~]]		[[Category: Acharya KR]]
	[[Category: Holloway~~, D E~~]]		[[Category: Holloway DE]]
	[[Category: Papageorgiou~~, A C~~]]		[[Category: Papageorgiou AC]]
	[[Category: Swaminathan~~, G J]]~~		[[Category: Swaminathan GJ]]
	~~[[Category: Chemokine]]~~
	~~[[Category: Chemotaxis]]~~
	~~[[Category: Inflammatory response]]~~
	~~[[Category: Interferon induction~~]]

OCA at 07:09, 25 August 2021

2021-08-25T07:09:39Z

← Older revision		Revision as of 07:09, 25 August 2021
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	<StructureSection load='1o7z' size='340' side='right'caption='[[1o7z]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='1o7z' size='340' side='right'caption='[[1o7z]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o7z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1O7Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o7z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O7Z FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lv9\|1lv9]], [[1o7y\|1o7y]], [[1o80\|1o80]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lv9\|1lv9]], [[1o7y\|1o7y]], [[1o80\|1o80]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1o7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7z OCA], [~~http~~://pdbe.org/1o7z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1o7z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1o7z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7z OCA], [https://pdbe.org/1o7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o7z RCSB], [https://www.ebi.ac.uk/pdbsum/1o7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CXL10_HUMAN CXL10_HUMAN]] Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.		[[https://www.uniprot.org/uniprot/CXL10_HUMAN CXL10_HUMAN]] Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 18:48, 20 November 2019

2019-11-20T18:48:36Z

← Older revision		Revision as of 18:48, 20 November 2019
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	==Crystal structure of IP-10 T-form==		==Crystal structure of IP-10 T-form==
	<StructureSection load='1o7z' size='340' side='right' caption='[[1o7z]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='1o7z' size='340' side='right'caption='[[1o7z]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o7z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o7z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7Z FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 1o7z" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1o7z" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[C-X-C motif chemokine 3D structures\|C-X-C motif chemokine 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]
	[[Category: Holloway, D E]]		[[Category: Holloway, D E]]

OCA at 07:34, 7 February 2018

2018-02-07T07:34:57Z

← Older revision		Revision as of 07:34, 7 February 2018
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	==~~CRYSTAL STRUCTURE OF~~ IP-10 T-~~FORM~~==
			==Crystal structure of IP-10 T-form==
	<StructureSection load='1o7z' size='340' side='right' caption='[[1o7z]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='1o7z' size='340' side='right' caption='[[1o7z]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o7z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o7z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7Z FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lv9\|1lv9]], [[1o7y\|1o7y]], [[1o80\|1o80]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lv9\|1lv9]], [[1o7y\|1o7y]], [[1o80\|1o80]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7z OCA], [http://pdbe.org/1o7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o7z RCSB], [http://www.ebi.ac.uk/pdbsum/1o7z PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7z OCA], [http://pdbe.org/1o7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o7z RCSB], [http://www.ebi.ac.uk/pdbsum/1o7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1o7z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/1o7z_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/1o7z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 1o7z" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1o7z" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[C-X-C motif chemokine\|C-X-C motif chemokine]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:32, 8 February 2016

2016-02-08T17:32:52Z

← Older revision		Revision as of 17:32, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o7z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:51, 10 September 2015

2015-09-10T13:51:24Z

← Older revision		Revision as of 13:51, 10 September 2015
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	<table><tr><td colspan='2'>[[1o7z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o7z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7Z FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lv9\|1lv9]], [[1o7y\|1o7y]], [[1o80\|1o80]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lv9\|1lv9]], [[1o7y\|1o7y]], [[1o80\|1o80]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o7z RCSB], [http://www.ebi.ac.uk/pdbsum/1o7z PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7z OCA], [http://pdbe.org/1o7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o7z RCSB], [http://www.ebi.ac.uk/pdbsum/1o7z PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1o7z" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 01:00, 25 December 2014

2014-12-25T01:00:35Z

← Older revision		Revision as of 01:00, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1o7z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[1o7z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7Z FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lv9\|1lv9]], [[1o7y\|1o7y]], [[1o80\|1o80]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lv9\|1lv9]], [[1o7y\|1o7y]], [[1o80\|1o80]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o7z RCSB], [http://www.ebi.ac.uk/pdbsum/1o7z PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o7z RCSB], [http://www.ebi.ac.uk/pdbsum/1o7z PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CXL10_HUMAN CXL10_HUMAN]] Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Acharya, K R.]]		[[Category: Acharya, K R]]
	[[Category: Holloway, D E.]]		[[Category: Holloway, D E]]
	[[Category: Papageorgiou, A C.]]		[[Category: Papageorgiou, A C]]
	[[Category: Swaminathan, G J.]]		[[Category: Swaminathan, G J]]
	[[Category: Chemokine]]		[[Category: Chemokine]]
	[[Category: Chemotaxis]]		[[Category: Chemotaxis]]
	[[Category: Inflammatory response]]		[[Category: Inflammatory response]]
	[[Category: Interferon induction]]		[[Category: Interferon induction]]

OCA at 15:48, 28 September 2014

2014-09-28T15:48:38Z

← Older revision		Revision as of 15:48, 28 September 2014
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	[[Image:~~1o7z~~.~~png~~\|~~left~~\|~~200px~~]]		==CRYSTAL STRUCTURE OF IP-10 T-FORM==
			<StructureSection load='1o7z' size='340' side='right' caption='[[1o7z]], [[Resolution\|resolution]] 1.92Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1o7z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O7Z FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lv9\|1lv9]], [[1o7y\|1o7y]], [[1o80\|1o80]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o7z RCSB], [http://www.ebi.ac.uk/pdbsum/1o7z PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o7/1o7z_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			We have determined the structure of wild-type IP-10 from three crystal forms. The crystals provide eight separate models of the IP-10 chain, all differing substantially from a monomeric IP-10 variant examined previously by NMR spectroscopy. In each crystal form, IP-10 chains form conventional beta sheet dimers, which, in turn, form a distinct tetrameric assembly. The M form tetramer is reminiscent of platelet factor 4, whereas the T and H forms feature a novel twelve-stranded beta sheet. Analytical ultracentrifugation indicates that, in free solution, IP-10 exists in a monomer-dimer equilibrium with a dissociation constant of 9 microM. We propose that the tetrameric structures may represent species promoted by the binding of glycosaminoglycans. The binding sites for several IP-10-neutralizing mAbs have also been mapped.

	~~{{STRUCTURE_1o7z\| PDB=1o7z \| SCENE= }}~~		Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine.,Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, Luster AD, Acharya KR Structure. 2003 May;11(5):521-32. PMID:12737818<ref>PMID:12737818</ref>

	~~===CRYSTAL STRUCTURE OF IP-10 T-FORM===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_12737818}}~~		==See Also==
			*[[C-X-C motif chemokine\|C-X-C motif chemokine]]
	==~~About this Structure~~==		== References ==
	[[~~1o7z~~]] ~~is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA].~~		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:012737818<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Acharya, K R.]]		[[Category: Acharya, K R.]]
	[[Category: Holloway, D E.]]		[[Category: Holloway, D E.]]

OCA: Protected "1o7z" [edit=sysop:move=sysop]

2012-12-12T22:03:32Z

Protected "1o7z" [edit=sysop:move=sysop]

← Older revision	Revision as of 22:03, 12 December 2012
(No difference)

OCA at 22:03, 12 December 2012

2012-12-12T22:03:24Z

← Older revision		Revision as of 22:03, 12 December 2012
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	~~{{Seed}}~~
	[[Image:1o7z.png\|left\|200px]]		[[Image:1o7z.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_1o7z", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_1o7z\| PDB=1o7z \| SCENE= }}		{{STRUCTURE_1o7z\| PDB=1o7z \| SCENE= }}

	===CRYSTAL STRUCTURE OF IP-10 T-FORM===		===CRYSTAL STRUCTURE OF IP-10 T-FORM===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_12737818}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 12737818 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_12737818}}		{{ABSTRACT_PUBMED_12737818}}

	==About this Structure==		==About this Structure==
	~~1O7Z~~ is a 2 ~~chains~~ structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA].		[[1o7z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~12737818~~</ref><references group="xtra"/>		<ref group="xtra">PMID:012737818</ref><references group="xtra"/>
	[[Category: Acharya, K R.]]		[[Category: Acharya, K R.]]
	[[Category: Holloway, D E.]]		[[Category: Holloway, D E.]]
	[[Category: Papageorgiou, A C.]]		[[Category: Papageorgiou, A C.]]
	[[Category: Swaminathan, G J.]]		[[Category: Swaminathan, G J.]]
	[[Category: Chemokine~~,interferon induction,chemotaxis,inflammatory response~~]]		[[Category: Chemokine]]
			[[Category: Chemotaxis]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 00~~:~~48:53 2009''~~		[[Category: Inflammatory response]]
			[[Category: Interferon induction]]