1ob1 - Revision history

OCA at 07:32, 23 October 2024

2024-10-23T07:32:29Z

← Older revision		Revision as of 07:32, 23 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/1ob1_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/1ob1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 12:33, 13 December 2023

2023-12-13T12:33:21Z

← Older revision		Revision as of 12:33, 13 December 2023
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	<StructureSection load='1ob1' size='340' side='right'caption='[[1ob1]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1ob1' size='340' side='right'caption='[[1ob1]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ob1]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [~~http~~://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1OB1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ob1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OB1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1ob1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ob1 OCA], [~~http~~://pdbe.org/1ob1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ob1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ob1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ob1 ProSAT]</span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ob1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ob1 OCA], [https://pdbe.org/1ob1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ob1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ob1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ob1 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/A0A5E3_MOUSE A0A5E3_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: ~~Plafa~~]]		[[Category: Plasmodium falciparum]]
	[[Category: Bentley~~, G A~~]]		[[Category: Bentley GA]]
	[[Category: Chitarra, V]]		[[Category: Chitarra V]]
	[[Category: Dartville, S]]		[[Category: Dartville S]]
	[[Category: Holm, I]]		[[Category: Holm I]]
	[[Category: Longacre, S]]		[[Category: Longacre S]]
	[[Category: Nato, F]]		[[Category: Nato F]]
	[[Category: Petres, S]]		[[Category: Petres S]]
	[[Category: Pizarro~~, J C~~]]		[[Category: Pizarro JC]]
	[[Category: Verger, D]]		[[Category: Verger D]]
	~~[[Category: Antibody fab fragment]]~~
	~~[[Category: Egf-like domain]]~~
	~~[[Category: Immune system]]~~
	~~[[Category: Immunoglobulin]]~~
	~~[[Category: Immunoglobulin-complex]]~~
	~~[[Category: Malaria vaccine component]]~~
	~~[[Category: Msp1-19]]~~
	~~[[Category: Surface antigen~~]]

OCA at 09:19, 6 January 2021

2021-01-06T09:19:44Z

← Older revision		Revision as of 09:19, 6 January 2021
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	<StructureSection load='1ob1' size='340' side='right'caption='[[1ob1]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1ob1' size='340' side='right'caption='[[1ob1]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ob1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1OB1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ob1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1OB1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ob1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ob1 OCA], [http://pdbe.org/1ob1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ob1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ob1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ob1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ob1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ob1 OCA], [http://pdbe.org/1ob1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ob1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ob1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ob1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
			*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:18, 3 April 2019

2019-04-03T07:18:49Z

← Older revision		Revision as of 07:18, 3 April 2019
Line 1:		Line 1:

	==Crystal structure of a Fab complex whith Plasmodium falciparum MSP1-19==		==Crystal structure of a Fab complex whith Plasmodium falciparum MSP1-19==
	<StructureSection load='1ob1' size='340' side='right' caption='[[1ob1]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1ob1' size='340' side='right'caption='[[1ob1]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ob1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OB1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ob1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OB1 FirstGlance]. <br>
Line 26:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1ob1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1ob1" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Plafa]]		[[Category: Plafa]]

OCA at 07:18, 7 February 2018

2018-02-07T07:18:07Z

← Older revision		Revision as of 07:18, 7 February 2018
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	==~~CRYSTAL STRUCTURE OF A FAB COMPLEX WHITH PLASMODIUM FALCIPARUM~~ MSP1-19==
			==Crystal structure of a Fab complex whith Plasmodium falciparum MSP1-19==
	<StructureSection load='1ob1' size='340' side='right' caption='[[1ob1]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1ob1' size='340' side='right' caption='[[1ob1]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ob1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OB1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ob1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OB1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ob1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ob1 OCA], [http://pdbe.org/1ob1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ob1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ob1 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ob1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ob1 OCA], [http://pdbe.org/1ob1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ob1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ob1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ob1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/1ob1_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/1ob1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 25:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1ob1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1ob1" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Antibody\|Antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:08, 8 February 2016

2016-02-08T06:08:29Z

← Older revision		Revision as of 06:08, 8 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ob1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:38, 10 September 2015

2015-09-10T08:38:50Z

← Older revision		Revision as of 08:38, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1ob1' size='340' side='right' caption='[[1ob1]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1ob1' size='340' side='right' caption='[[1ob1]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ob1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OB1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ob1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OB1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ob1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ob1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ob1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ob1 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ob1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ob1 OCA], [http://pdbe.org/1ob1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ob1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ob1 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1ob1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: ~~Plasmodium falciparum~~]]		[[Category: Plafa]]
	[[Category: Bentley, G A]]		[[Category: Bentley, G A]]
	[[Category: Chitarra, V]]		[[Category: Chitarra, V]]

OCA at 15:47, 5 January 2015

2015-01-05T15:47:12Z

← Older revision		Revision as of 15:47, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ob1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OB1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ob1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OB1 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ob1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ob1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ob1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ob1 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ob1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ob1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ob1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ob1 PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Bentley, G A.]]		[[Category: Bentley, G A]]
	[[Category: Chitarra, V.]]		[[Category: Chitarra, V]]
	[[Category: Dartville, S.]]		[[Category: Dartville, S]]
	[[Category: Holm, I.]]		[[Category: Holm, I]]
	[[Category: Longacre, S.]]		[[Category: Longacre, S]]
	[[Category: Nato, F.]]		[[Category: Nato, F]]
	[[Category: Petres, S.]]		[[Category: Petres, S]]
	[[Category: Pizarro, J C.]]		[[Category: Pizarro, J C]]
	[[Category: Verger, D.]]		[[Category: Verger, D]]
	[[Category: Antibody fab fragment]]		[[Category: Antibody fab fragment]]
	[[Category: Egf-like domain]]		[[Category: Egf-like domain]]

OCA at 16:59, 29 September 2014

2014-09-29T16:59:09Z

← Older revision		Revision as of 16:59, 29 September 2014
Line 1:		Line 1:
	[[Image:~~1ob1~~.~~png~~\|~~left~~\|~~200px~~]]		==CRYSTAL STRUCTURE OF A FAB COMPLEX WHITH PLASMODIUM FALCIPARUM MSP1-19==
			<StructureSection load='1ob1' size='340' side='right' caption='[[1ob1]], [[Resolution\|resolution]] 2.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1ob1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OB1 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ob1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ob1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ob1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ob1 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/1ob1_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Merozoite surface protein 1 (MSP1) is the major protein component on the surface of the merozoite, the erythrocyte-invasive form of the malaria parasite Plasmodium. Present in all species of Plasmodium, it undergoes two distinct proteolytic maturation steps during the course of merozoite development that are essential for invasion of the erythrocyte. Antibodies specific for the C-terminal maturation product, MSP1-19, can inhibit erythrocyte invasion and parasite growth. This polypeptide is therefore considered to be one of the more promising malaria vaccine candidates. We describe here the crystal structure of recombinant MSP1-19 from P.falciparum (PfMSP1-19), the most virulent species of the parasite in humans, as a complex with the Fab fragment of the monoclonal antibody G17.12. This antibody recognises a discontinuous epitope comprising 13 residues on the first epidermal growth factor (EGF)-like domain of PfMSP1-19. Although G17.12 was raised against the recombinant antigen expressed in an insect cell/baculovirus system, it binds uniformly to the surface of merozoites from the late schizont stage, showing that the cognate epitope is exposed on the naturally occurring MSP1 polypeptide complex. Although the epitope includes residues that have been mapped to regions recognised by invasion-inhibiting antibodies studied by other workers, G17.12 does not inhibit erythrocyte invasion or MSP1 processing.

	~~{{STRUCTURE_1ob1\| PDB=1ob1 \| SCENE= }}~~		Crystal structure of a Fab complex formed with PfMSP1-19, the C-terminal fragment of merozoite surface protein 1 from Plasmodium falciparum: a malaria vaccine candidate.,Pizarro JC, Chitarra V, Verger D, Holm I, Petres S, Dartevelle S, Nato F, Longacre S, Bentley GA J Mol Biol. 2003 May 16;328(5):1091-103. PMID:12729744<ref>PMID:12729744</ref>

	~~===CRYSTAL STRUCTURE OF A FAB COMPLEX WHITH PLASMODIUM FALCIPARUM MSP1-19===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_12729744}}~~		==See Also==
			*[[Antibody\|Antibody]]
	==~~About this Structure~~==		== References ==
	[[~~1ob1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OB1 OCA~~].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:012729744<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]

OCA at 09:54, 16 January 2013

2013-01-16T09:54:05Z

← Older revision		Revision as of 09:54, 16 January 2013
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	[[Image:1ob1.png\|left\|200px]]		[[Image:1ob1.png\|left\|200px]]

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	===CRYSTAL STRUCTURE OF A FAB COMPLEX WHITH PLASMODIUM FALCIPARUM MSP1-19===		===CRYSTAL STRUCTURE OF A FAB COMPLEX WHITH PLASMODIUM FALCIPARUM MSP1-19===


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	==Reference==		==Reference==
	<ref group="xtra">PMID:~~12729744</ref><ref group="xtra">PMID:12077458~~</ref><references group="xtra"/>		<ref group="xtra">PMID:012729744</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
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	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]
	[[Category: Immunoglobulin/complex]]		[[Category: Immunoglobulin-complex]]
	[[Category: Malaria vaccine component]]		[[Category: Malaria vaccine component]]
	~~[[Category: Merozoite surface protein 1]]~~
	[[Category: Msp1-19]]		[[Category: Msp1-19]]
	[[Category: Surface antigen]]		[[Category: Surface antigen]]