1sql - Revision history

OCA at 06:20, 23 August 2023

2023-08-23T06:20:06Z

← Older revision		Revision as of 06:20, 23 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1sql]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1sql]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sql OCA], [https://pdbe.org/1sql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sql RCSB], [https://www.ebi.ac.uk/pdbsum/1sql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sql ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sql OCA], [https://pdbe.org/1sql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sql RCSB], [https://www.ebi.ac.uk/pdbsum/1sql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sql ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/FOLB1_ARATH FOLB1_ARATH]] Catalyzes the conversion of 7,8-dihydroneopterin into 6-hydroxymethyl-7,8-dihydropterin, a biosynthetic precursor of the vitamin tetrahydrofolate.		[https://www.uniprot.org/uniprot/FOLB1_ARATH FOLB1_ARATH] Catalyzes the conversion of 7,8-dihydroneopterin into 6-hydroxymethyl-7,8-dihydropterin, a biosynthetic precursor of the vitamin tetrahydrofolate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bacher, A]]		[[Category: Bacher A]]
	[[Category: Bauer, S]]		[[Category: Bauer S]]
	[[Category: Fischer, M]]		[[Category: Fischer M]]
	[[Category: Huber, R]]		[[Category: Huber R]]
	[[Category: Illarionova, V]]		[[Category: Illarionova V]]
	[[Category: Schott~~, A K]]~~		[[Category: Schott AK]]
	~~[[Category: Aldolase class]]~~
	~~[[Category: Lyase]]~~
	~~[[Category: Purin binding]]~~
	~~[[Category: Retroaldol reaction]]~~
	~~[[Category: Schiff base]]~~
	~~[[Category: Tetrahydrofolate biosynthesis~~]]

OCA at 07:35, 22 September 2021

2021-09-22T07:35:56Z

← Older revision		Revision as of 07:35, 22 September 2021
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	<StructureSection load='1sql' size='340' side='right'caption='[[1sql]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1sql' size='340' side='right'caption='[[1sql]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1sql]] is a 16 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1SQL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1sql]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sql OCA], [~~http~~://pdbe.org/1sql PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1sql RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1sql PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1sql ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sql OCA], [https://pdbe.org/1sql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sql RCSB], [https://www.ebi.ac.uk/pdbsum/1sql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sql ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/FOLB1_ARATH FOLB1_ARATH]] Catalyzes the conversion of 7,8-dihydroneopterin into 6-hydroxymethyl-7,8-dihydropterin, a biosynthetic precursor of the vitamin tetrahydrofolate.		[[https://www.uniprot.org/uniprot/FOLB1_ARATH FOLB1_ARATH]] Catalyzes the conversion of 7,8-dihydroneopterin into 6-hydroxymethyl-7,8-dihydropterin, a biosynthetic precursor of the vitamin tetrahydrofolate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:59, 18 December 2019

2019-12-18T13:59:07Z

← Older revision		Revision as of 13:59, 18 December 2019
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	==Crystal structure of 7,8-dihydroneopterin aldolase in complex with guanine==		==Crystal structure of 7,8-dihydroneopterin aldolase in complex with guanine==
	<StructureSection load='1sql' size='340' side='right' caption='[[1sql]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1sql' size='340' side='right'caption='[[1sql]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1sql]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SQL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1sql]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SQL FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Aldolase\|Aldolase]]		*[[Aldolase 3D structures\|Aldolase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
			[[Category: Large Structures]]
	[[Category: Bacher, A]]		[[Category: Bacher, A]]
	[[Category: Bauer, S]]		[[Category: Bauer, S]]

OCA at 07:42, 14 March 2018

2018-03-14T07:42:20Z

← Older revision		Revision as of 07:42, 14 March 2018
Line 1:		Line 1:

	==Crystal structure of 7,8-dihydroneopterin aldolase in complex with guanine==		==Crystal structure of 7,8-dihydroneopterin aldolase in complex with guanine==
	<StructureSection load='1sql' size='340' side='right' caption='[[1sql]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1sql' size='340' side='right' caption='[[1sql]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1sql]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SQL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1sql]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SQL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sql OCA], [http://pdbe.org/1sql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sql RCSB], [http://www.ebi.ac.uk/pdbsum/1sql PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sql OCA], [http://pdbe.org/1sql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sql RCSB], [http://www.ebi.ac.uk/pdbsum/1sql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sql ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sql_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sql_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sql ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:08, 11 September 2015

2015-09-11T12:08:41Z

← Older revision		Revision as of 12:08, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1sql]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SQL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1sql]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SQL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sql OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sql RCSB], [http://www.ebi.ac.uk/pdbsum/1sql PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sql OCA], [http://pdbe.org/1sql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sql RCSB], [http://www.ebi.ac.uk/pdbsum/1sql PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1sql" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:15, 25 December 2014

2014-12-25T16:15:36Z

← Older revision		Revision as of 16:15, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1sql]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SQL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1sql]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SQL FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sql OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sql RCSB], [http://www.ebi.ac.uk/pdbsum/1sql PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sql OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sql RCSB], [http://www.ebi.ac.uk/pdbsum/1sql PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/FOLB1_ARATH FOLB1_ARATH]] Catalyzes the conversion of 7,8-dihydroneopterin into 6-hydroxymethyl-7,8-dihydropterin, a biosynthetic precursor of the vitamin tetrahydrofolate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Bacher, A.]]		[[Category: Bacher, A]]
	[[Category: Bauer, S.]]		[[Category: Bauer, S]]
	[[Category: Fischer, M.]]		[[Category: Fischer, M]]
	[[Category: Huber, R.]]		[[Category: Huber, R]]
	[[Category: Illarionova, V.]]		[[Category: Illarionova, V]]
	[[Category: Schott, A K.]]		[[Category: Schott, A K]]
	[[Category: Aldolase class]]		[[Category: Aldolase class]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA at 21:01, 28 September 2014

2014-09-28T21:01:00Z

← Older revision		Revision as of 21:01, 28 September 2014
Line 1:		Line 1:
	[[Image:~~1sql~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of 7,8-dihydroneopterin aldolase in complex with guanine==
			<StructureSection load='1sql' size='340' side='right' caption='[[1sql]], [[Resolution\|resolution]] 2.20Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1sql]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SQL FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sql OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sql RCSB], [http://www.ebi.ac.uk/pdbsum/1sql PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sql_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Dihydroneopterin aldolase (DHNA) catalyses a retroaldol reaction yielding 6-hydroxymethyl-7,8-dihydropterin, a biosynthetic precursor of the vitamin, tetrahydrofolate. The enzyme is a potential target for antimicrobial and anti-parasite chemotherapy. A gene specifying a dihydroneopterin aldolase from Arabidopsis thaliana was expressed in a recombinant Escherichia coli strain. The recombinant protein was purified to apparent homogeneity and crystallised using polyethylenglycol as the precipitating agent. The crystal structure was solved by X-ray diffraction analysis at 2.2A resolution. The enzyme forms a D(4)-symmetric homooctamer. Each polypeptide chain is folded into a single domain comprising an antiparallel four-stranded beta-sheet and two long alpha-helices. Four monomers are arranged in a tetrameric ring, and two of these rings form a hollow cylinder. Well defined purine derivatives are found at all eight topologically equivalent active sites. The subunit fold of the enzyme is related to substructures of dihydroneopterin triphosphate epimerase, GTP cyclohydrolase I, and pyruvoyltetrahydropterin synthase, which are all involved in the biosynthesis of pteridine type cofactors, and to urate oxidase, although some members of that superfamily have no detectable sequence similarity. Due to structural and mechanistical differences of DHNA in comparison with class I and class II aldolases, a new aldolase class is proposed.

	~~{{STRUCTURE_1sql\| PDB=1sql \| SCENE= }}~~		Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class.,Bauer S, Schott AK, Illarionova V, Bacher A, Huber R, Fischer M J Mol Biol. 2004 Jun 11;339(4):967-79. PMID:15165863<ref>PMID:15165863</ref>

	~~===Crystal structure of 7~~,~~8-dihydroneopterin aldolase in complex with guanine===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_15165863}}~~

	~~==About this Structure==~~
	~~[[1sql]] is~~ a ~~16 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=1SQL OCA].~~

	==See Also==		==See Also==
	*[[Aldolase\|Aldolase]]		*[[Aldolase\|Aldolase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:015165863<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Bacher, A.]]		[[Category: Bacher, A.]]

OCA at 18:47, 20 October 2012

2012-10-20T18:47:24Z

← Older revision		Revision as of 18:47, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[1sql]] is a 16 chain structure ~~of [[Aldolase]]~~ with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA].		[[1sql]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA].

	==See Also==		==See Also==

OCA: Protected "1sql" [edit=sysop:move=sysop]

2012-07-27T05:14:40Z

Protected "1sql" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:14, 27 July 2012
(No difference)

OCA at 05:14, 27 July 2012

2012-07-27T05:14:38Z

← Older revision		Revision as of 05:14, 27 July 2012
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	~~{{Seed}}~~
	[[Image:1sql.png\|left\|200px]]		[[Image:1sql.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_1sql", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_1sql\| PDB=1sql \| SCENE= }}		{{STRUCTURE_1sql\| PDB=1sql \| SCENE= }}

	===Crystal structure of 7,8-dihydroneopterin aldolase in complex with guanine===		===Crystal structure of 7,8-dihydroneopterin aldolase in complex with guanine===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_15165863}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 15165863 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_15165863}}		{{ABSTRACT_PUBMED_15165863}}

	==About this Structure==		==About this Structure==
	~~1SQL~~ is a 16 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA].		[[1sql]] is a 16 chain structure of [[Aldolase]] with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQL OCA].

			==See Also==
			*[[Aldolase\|Aldolase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~15165863~~</ref><references group="xtra"/>		<ref group="xtra">PMID:015165863</ref><references group="xtra"/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Bacher, A.]]		[[Category: Bacher, A.]]
Line 32:		Line 23:
	[[Category: Schott, A K.]]		[[Category: Schott, A K.]]
	[[Category: Aldolase class]]		[[Category: Aldolase class]]
			[[Category: Lyase]]
	[[Category: Purin binding]]		[[Category: Purin binding]]
	[[Category: Retroaldol reaction]]		[[Category: Retroaldol reaction]]
	[[Category: Schiff base]]		[[Category: Schiff base]]
	[[Category: Tetrahydrofolate biosynthesis]]		[[Category: Tetrahydrofolate biosynthesis]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:29:20 2009''~~