1ss2 - Revision history

OCA at 08:49, 6 November 2024

2024-11-06T08:49:05Z

← Older revision		Revision as of 08:49, 6 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ss2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SS2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ss2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SS2 FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 24 models</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [https://pdbe.org/1ss2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ss2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ss2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [https://pdbe.org/1ss2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ss2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ss2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:24, 6 December 2023

2023-12-06T09:24:53Z

← Older revision		Revision as of 09:24, 6 December 2023
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	==Solution structure of the second complement control protein (CCP) module of the GABA(B)R1a receptor, Pro-119 cis conformer==		==Solution structure of the second complement control protein (CCP) module of the GABA(B)R1a receptor, Pro-119 cis conformer==
	<StructureSection load='1ss2' size='340' side='right'caption='[[1ss2~~]], [[NMR_Ensembles_of_Models \| 24 NMR models~~]]' scene=''>		<StructureSection load='1ss2' size='340' side='right'caption='[[1ss2]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ss2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SS2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ss2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SS2 FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1srz\|1srz]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	~~<tr~~ id~~='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class~~="~~sblockDat~~">~~GABBR1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [https://pdbe.org/1ss2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ss2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ss2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [https://pdbe.org/1ss2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ss2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ss2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/GABR1_RAT GABR1_RAT]] Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.		[https://www.uniprot.org/uniprot/GABR1_RAT GABR1_RAT] Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Buffalo rat]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Barlow~~, P N~~]]		[[Category: Rattus norvegicus]]
	[[Category: Blein, S]]		[[Category: Barlow PN]]
	[[Category: Smith~~, B O~~]]		[[Category: Blein S]]
	[[Category: Uhrin, D]]		[[Category: Smith BO]]
	[[Category: White~~, J H]]~~		[[Category: Uhrin D]]
	~~[[Category: Ccp module]]~~		[[Category: White JH]]
	~~[[Category: Cis-trans isomerisation]]~~
	~~[[Category: Short consensus repeat]]~~
	~~[[Category: Signaling protein]]~~
	~~[[Category: Sushi domain~~]]

OCA at 06:36, 2 March 2022

2022-03-02T06:36:54Z

← Older revision		Revision as of 06:36, 2 March 2022
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	<StructureSection load='1ss2' size='340' side='right'caption='[[1ss2]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>		<StructureSection load='1ss2' size='340' side='right'caption='[[1ss2]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ss2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1SS2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ss2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SS2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1srz\|1srz]]</div></td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1srz\|1srz]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABBR1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABBR1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [~~http~~://pdbe.org/1ss2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ss2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ss2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [https://pdbe.org/1ss2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ss2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ss2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/GABR1_RAT GABR1_RAT]] Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.		[[https://www.uniprot.org/uniprot/GABR1_RAT GABR1_RAT]] Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:33, 24 December 2020

2020-12-24T11:33:06Z

← Older revision		Revision as of 11:33, 24 December 2020
Line 1:		Line 1:

	==Solution structure of the second complement control protein (CCP) module of the GABA(B)R1a receptor, Pro-119 cis conformer==		==Solution structure of the second complement control protein (CCP) module of the GABA(B)R1a receptor, Pro-119 cis conformer==
	<StructureSection load='1ss2' size='340' side='right' caption='[[1ss2]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>		<StructureSection load='1ss2' size='340' side='right'caption='[[1ss2]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ss2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS2 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1SS2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ss2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1SS2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1srz\|1srz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1srz\|1srz]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABBR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABBR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [http://pdbe.org/1ss2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [http://www.ebi.ac.uk/pdbsum/1ss2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ss2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [http://pdbe.org/1ss2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [http://www.ebi.ac.uk/pdbsum/1ss2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ss2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
	*[[GABA receptor\|GABA receptor]]		*[[GABA receptor 3D structures\|GABA receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
			[[Category: Large Structures]]
	[[Category: Barlow, P N]]		[[Category: Barlow, P N]]
	[[Category: Blein, S]]		[[Category: Blein, S]]

OCA at 07:27, 14 March 2018

2018-03-14T07:27:07Z

← Older revision		Revision as of 07:27, 14 March 2018
Line 1:		Line 1:

	==Solution structure of the second complement control protein (CCP) module of the GABA(B)R1a receptor, Pro-119 cis conformer==		==Solution structure of the second complement control protein (CCP) module of the GABA(B)R1a receptor, Pro-119 cis conformer==
	<StructureSection load='1ss2' size='340' side='right' caption='[[1ss2]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>		<StructureSection load='1ss2' size='340' side='right' caption='[[1ss2]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1srz\|1srz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1srz\|1srz]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABBR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABBR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [http://pdbe.org/1ss2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [http://www.ebi.ac.uk/pdbsum/1ss2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [http://pdbe.org/1ss2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [http://www.ebi.ac.uk/pdbsum/1ss2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ss2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1ss2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1ss2" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[GABA receptor\|GABA receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:41, 11 September 2015

2015-09-11T12:41:49Z

← Older revision		Revision as of 12:41, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1ss2' size='340' side='right' caption='[[1ss2]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>		<StructureSection load='1ss2' size='340' side='right' caption='[[1ss2]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ss2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SS2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ss2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SS2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1srz\|1srz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1srz\|1srz]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABBR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABBR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [http://www.ebi.ac.uk/pdbsum/1ss2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [http://pdbe.org/1ss2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [http://www.ebi.ac.uk/pdbsum/1ss2 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1ss2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Rattus norvegicus~~]]		[[Category: Buffalo rat]]
	[[Category: Barlow, P N]]		[[Category: Barlow, P N]]
	[[Category: Blein, S]]		[[Category: Blein, S]]

OCA at 16:35, 25 December 2014

2014-12-25T16:35:37Z

← Older revision		Revision as of 16:35, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [http://www.ebi.ac.uk/pdbsum/1ss2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [http://www.ebi.ac.uk/pdbsum/1ss2 PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/GABR1_RAT GABR1_RAT]] Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Barlow, P N.]]		[[Category: Barlow, P N]]
	[[Category: Blein, S.]]		[[Category: Blein, S]]
	[[Category: Smith, B O.]]		[[Category: Smith, B O]]
	[[Category: Uhrin, D.]]		[[Category: Uhrin, D]]
	[[Category: White, J H.]]		[[Category: White, J H]]
	[[Category: Ccp module]]		[[Category: Ccp module]]
	[[Category: Cis-trans isomerisation]]		[[Category: Cis-trans isomerisation]]

OCA at 08:17, 8 October 2014

2014-10-08T08:17:28Z

← Older revision		Revision as of 08:17, 8 October 2014
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	[[~~Image~~:~~1ss2~~.~~png~~\|~~left~~\|~~200px~~]]		==Solution structure of the second complement control protein (CCP) module of the GABA(B)R1a receptor, Pro-119 cis conformer==
			<StructureSection load='1ss2' size='340' side='right' caption='[[1ss2]], [[NMR_Ensembles_of_Models \| 24 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1ss2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SS2 FirstGlance]. <br>
			</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1srz\|1srz]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GABBR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ss2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ss2 RCSB], [http://www.ebi.ac.uk/pdbsum/1ss2 PDBsum]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The gamma-aminobutyric acid type B (GABA(B)) receptor is a heterodimeric G-protein-coupled receptor. In humans, three splice variants of the GABA(B) receptor 1 (R1) subunit differ in having one, both, or neither of two putative complement control protein (CCP) modules at the extracellular N terminus, prior to the GABA-binding domain. The in vivo function of these predicted modules remains to be discovered, but a likely association with extracellular matrix proteins is intriguing. The portion of the GABA(B) R1a variant encompassing both of its CCP module-like sequences has been expressed, as have the sequences corresponding to each individual module. Each putative CCP module exhibits the expected pattern of disulfide formation. However, the second module (CCP2) is more compactly folded than the first, and the three-dimensional structure of this more C-terminal module (expressed alone) was solved on the basis of NMR-derived nuclear Overhauser effects. This revealed a strong similarity to previously determined CCP module structures in the regulators of complement activation. The N-terminal module (CCP1) displayed conformational heterogeneity under a wide range of conditions whether expressed alone or together with CCP2. Several lines of evidence indicated the presence of native disorder in CCP1, despite the fact that recombinant CCP1 contributes to binding to the extracellular matrix protein fibulin-2. Thus, we have shown that the two CCP modules of GABA(B) R1a have strikingly different structural properties, reflecting their different functions.

	~~{{STRUCTURE_1ss2\| PDB=1ss2 \| SCENE= }}~~		Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded.,Blein S, Ginham R, Uhrin D, Smith BO, Soares DC, Veltel S, McIlhinney RA, White JH, Barlow PN J Biol Chem. 2004 Nov 12;279(46):48292-306. Epub 2004 Aug 9. PMID:15304491<ref>PMID:15304491</ref>

	~~===Solution structure~~ of the ~~second complement control protein (CCP) module~~ of ~~the GABA(B)R1a receptor, Pro-119 cis conformer===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_15304491}}~~		== References ==
			<references/>
	==~~About this Structure~~==		__TOC__
	~~[[1ss2]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS2 OCA].~~		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Barlow, P N.]]		[[Category: Barlow, P N.]]

OCA: Protected "1ss2" [edit=sysop:move=sysop]

2013-01-04T10:01:04Z

Protected "1ss2" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:01, 4 January 2013
(No difference)

OCA at 10:01, 4 January 2013

2013-01-04T10:01:02Z

← Older revision		Revision as of 10:01, 4 January 2013
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	~~{{Seed}}~~
	[[Image:1ss2.png\|left\|200px]]		[[Image:1ss2.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_1ss2", creates the "Structure Box" on the page.~~
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	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
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	{{STRUCTURE_1ss2\| PDB=1ss2 \| SCENE= }}		{{STRUCTURE_1ss2\| PDB=1ss2 \| SCENE= }}

	===Solution structure of the second complement control protein (CCP) module of the GABA(B)R1a receptor, Pro-119 cis conformer===		===Solution structure of the second complement control protein (CCP) module of the GABA(B)R1a receptor, Pro-119 cis conformer===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_15304491}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_15304491}}		{{ABSTRACT_PUBMED_15304491}}

	==About this Structure==		==About this Structure==
	~~1SS2 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS2 OCA].		[[1ss2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS2 OCA].

	~~==Reference==~~
	Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded., Blein S, Ginham R, Uhrin D, Smith BO, Soares DC, Veltel S, McIlhinney RA, White JH, Barlow PN, J Biol Chem. 2004 Nov 12;279(46):48292-306. Epub 2004 Aug 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15304491 15304491]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	~~[[Category: Single protein]]~~
	[[Category: Barlow, P N.]]		[[Category: Barlow, P N.]]
	[[Category: Blein, S.]]		[[Category: Blein, S.]]
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	[[Category: Cis-trans isomerisation]]		[[Category: Cis-trans isomerisation]]
	[[Category: Short consensus repeat]]		[[Category: Short consensus repeat]]
			[[Category: Signaling protein]]
	[[Category: Sushi domain]]		[[Category: Sushi domain]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:07:25 2008''~~