1std - Revision history

OCA at 08:33, 14 February 2024

2024-02-14T08:33:33Z

← Older revision		Revision as of 08:33, 14 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1std]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyricularia_grisea Pyricularia grisea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1STD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1std]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyricularia_grisea Pyricularia grisea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1STD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFS:N-[1-(4-BROMOPHENYL)ETHYL]-5-FLUORO+SALICYLAMIDE'>BFS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFS:N-[1-(4-BROMOPHENYL)ETHYL]-5-FLUORO+SALICYLAMIDE'>BFS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1std FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1std OCA], [https://pdbe.org/1std PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1std RCSB], [https://www.ebi.ac.uk/pdbsum/1std PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1std ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1std FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1std OCA], [https://pdbe.org/1std PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1std RCSB], [https://www.ebi.ac.uk/pdbsum/1std PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1std ProSAT]</span></td></tr>
	</table>		</table>
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1std ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1std ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	BACKGROUND: Rice blast is caused by the pathogenic fungus,-Magnaporthe grisea. Non-pathogenic mutants have been identified that lack enzymes in the biosynthetic pathway of dihydroxynapthalene-derived melanin. These enzymes are therefore prime targets for fungicides designed to control rice blast disease. One of the enzymes identified by genetic analysis as a disease determinant is scytalone dehydratase. RESULTS: The three-dimensional structure of scytalone dehydratase in complex with a competitive inhibitor has been determined at 2.9 A resolution. A novel fold, a cone-shaped alpha + beta barrel, is adopted by the monomer in this trimeric protein, burying the hydrophobic active site in its interior. The interactions of the inhibitor with the protein side chains have been identified. The similarity of the inhibitor to the substrate and the side chains involved in binding afford some insights into possible catalytic mechanisms. CONCLUSIONS: These results provide a first look into the structure and catalytic residues of a non-metal dehydratase, a large class of hitherto structurally uncharacterized enzymes. It is envisaged that a detailed structural description of scytalone dehydratase will assist in the design of new inhibitors for controlling rice blast disease.

	Crystal structure of scytalone dehydratase--a disease determinant of the rice pathogen, Magnaporthe grisea.,Lundqvist T, Rice J, Hodge CN, Basarab GS, Pierce J, Lindqvist Y Structure. 1994 Oct 15;2(10):937-44. PMID:7866745<ref>PMID:7866745</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 1std" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 04:36, 30 September 2022

2022-09-30T04:36:13Z

← Older revision		Revision as of 04:36, 30 September 2022
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	<StructureSection load='1std' size='340' side='right'caption='[[1std]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1std' size='340' side='right'caption='[[1std]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1std]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Cbs_138707_[[pyricularia_grisea]] Cbs 138707 [[pyricularia~~ grisea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1STD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1std]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyricularia_grisea Pyricularia grisea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1STD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFS:N-[1-(4-BROMOPHENYL)ETHYL]-5-FLUORO+SALICYLAMIDE'>BFS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFS:N-[1-(4-BROMOPHENYL)ETHYL]-5-FLUORO+SALICYLAMIDE'>BFS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Scytalone_dehydratase Scytalone dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.94 4.2.1.94] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1std FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1std OCA], [https://pdbe.org/1std PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1std RCSB], [https://www.ebi.ac.uk/pdbsum/1std PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1std ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1std FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1std OCA], [https://pdbe.org/1std PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1std RCSB], [https://www.ebi.ac.uk/pdbsum/1std PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1std ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/SCYD_MAGO7 SCYD_MAGO7]] Catalyzes two steps in melanin biosynthesis. From scytalone they are two dehydration steps and one reduction step to yield melanin.		[https://www.uniprot.org/uniprot/SCYD_MAGO7 SCYD_MAGO7] Catalyzes two steps in melanin biosynthesis. From scytalone they are two dehydration steps and one reduction step to yield melanin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Scytalone dehydratase~~]]		[[Category: Pyricularia grisea]]
	[[Category: Lindqvist, Y]]		[[Category: Lindqvist Y]]
	[[Category: Lundqvist, T]]		[[Category: Lundqvist T]]

OCA at 07:37, 22 September 2021

2021-09-22T07:37:03Z

← Older revision		Revision as of 07:37, 22 September 2021
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	<StructureSection load='1std' size='340' side='right'caption='[[1std]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1std' size='340' side='right'caption='[[1std]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1std]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cbs_138707_[[pyricularia_grisea]] Cbs 138707 [[pyricularia grisea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1STD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1std]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cbs_138707_[[pyricularia_grisea]] Cbs 138707 [[pyricularia grisea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1STD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFS:N-[1-(4-BROMOPHENYL)ETHYL]-5-FLUORO+SALICYLAMIDE'>BFS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFS:N-[1-(4-BROMOPHENYL)ETHYL]-5-FLUORO+SALICYLAMIDE'>BFS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Scytalone_dehydratase Scytalone dehydratase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.94 4.2.1.94] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Scytalone_dehydratase Scytalone dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.94 4.2.1.94] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1std FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1std OCA], [~~http~~://pdbe.org/1std PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1std RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1std PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1std ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1std FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1std OCA], [https://pdbe.org/1std PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1std RCSB], [https://www.ebi.ac.uk/pdbsum/1std PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1std ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/SCYD_MAGO7 SCYD_MAGO7]] Catalyzes two steps in melanin biosynthesis. From scytalone they are two dehydration steps and one reduction step to yield melanin.		[[https://www.uniprot.org/uniprot/SCYD_MAGO7 SCYD_MAGO7]] Catalyzes two steps in melanin biosynthesis. From scytalone they are two dehydration steps and one reduction step to yield melanin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:18, 18 December 2019

2019-12-18T14:18:42Z

← Older revision		Revision as of 14:18, 18 December 2019
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	==CRYSTAL STRUCTURE OF SCYTALONE DEHYDRATASE: A DISEASE DETERMINANT OF THE RICE PATHOGEN, MAGNAPORTHE GRISEA==		==CRYSTAL STRUCTURE OF SCYTALONE DEHYDRATASE: A DISEASE DETERMINANT OF THE RICE PATHOGEN, MAGNAPORTHE GRISEA==
	<StructureSection load='1std' size='340' side='right' caption='[[1std]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1std' size='340' side='right'caption='[[1std]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1std]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_138707_[[pyricularia_grisea]] Cbs 138707 [[pyricularia grisea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1STD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1std]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_138707_[[pyricularia_grisea]] Cbs 138707 [[pyricularia grisea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1STD FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Scytalone dehydratase]]		[[Category: Scytalone dehydratase]]
	[[Category: Lindqvist, Y]]		[[Category: Lindqvist, Y]]
	[[Category: Lundqvist, T]]		[[Category: Lundqvist, T]]

OCA at 07:58, 14 March 2018

2018-03-14T07:58:50Z

← Older revision		Revision as of 07:58, 14 March 2018
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF SCYTALONE DEHYDRATASE: A DISEASE DETERMINANT OF THE RICE PATHOGEN, MAGNAPORTHE GRISEA==		==CRYSTAL STRUCTURE OF SCYTALONE DEHYDRATASE: A DISEASE DETERMINANT OF THE RICE PATHOGEN, MAGNAPORTHE GRISEA==
	<StructureSection load='1std' size='340' side='right' caption='[[1std]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1std' size='340' side='right' caption='[[1std]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1std]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Crabgrass-specific_blast_fungus Crabgrass-specific blast fungus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1STD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1std]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_138707_[[pyricularia_grisea]] Cbs 138707 [[pyricularia grisea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1STD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFS:N-[1-(4-BROMOPHENYL)ETHYL]-5-FLUORO+SALICYLAMIDE'>BFS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFS:N-[1-(4-BROMOPHENYL)ETHYL]-5-FLUORO+SALICYLAMIDE'>BFS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Scytalone_dehydratase Scytalone dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.94 4.2.1.94] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Scytalone_dehydratase Scytalone dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.94 4.2.1.94] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1std FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1std OCA], [http://pdbe.org/1std PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1std RCSB], [http://www.ebi.ac.uk/pdbsum/1std PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1std FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1std OCA], [http://pdbe.org/1std PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1std RCSB], [http://www.ebi.ac.uk/pdbsum/1std PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1std ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/st/1std_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/st/1std_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1std ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Crabgrass-specific blast fungus]]~~
	[[Category: Scytalone dehydratase]]		[[Category: Scytalone dehydratase]]
	[[Category: Lindqvist, Y]]		[[Category: Lindqvist, Y]]
	[[Category: Lundqvist, T]]		[[Category: Lundqvist, T]]

OCA at 00:59, 12 September 2015

2015-09-12T00:59:27Z

← Older revision		Revision as of 00:59, 12 September 2015
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	<StructureSection load='1std' size='340' side='right' caption='[[1std]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1std' size='340' side='right' caption='[[1std]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1std]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Magnaporthe_grisea Magnaporthe grisea~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1STD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1std]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Crabgrass-specific_blast_fungus Crabgrass-specific blast fungus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1STD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFS:N-[1-(4-BROMOPHENYL)ETHYL]-5-FLUORO+SALICYLAMIDE'>BFS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFS:N-[1-(4-BROMOPHENYL)ETHYL]-5-FLUORO+SALICYLAMIDE'>BFS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Scytalone_dehydratase Scytalone dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.94 4.2.1.94] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Scytalone_dehydratase Scytalone dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.94 4.2.1.94] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1std FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1std OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1std RCSB], [http://www.ebi.ac.uk/pdbsum/1std PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1std FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1std OCA], [http://pdbe.org/1std PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1std RCSB], [http://www.ebi.ac.uk/pdbsum/1std PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~SCYD_MAGGR SCYD_MAGGR~~]] Catalyzes two steps in melanin biosynthesis. From scytalone they are two dehydration steps and one reduction step to yield melanin.		[[http://www.uniprot.org/uniprot/SCYD_MAGO7 SCYD_MAGO7]] Catalyzes two steps in melanin biosynthesis. From scytalone they are two dehydration steps and one reduction step to yield melanin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1std" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Magnaporthe grisea~~]]		[[Category: Crabgrass-specific blast fungus]]
	[[Category: Scytalone dehydratase]]		[[Category: Scytalone dehydratase]]
	[[Category: Lindqvist, Y]]		[[Category: Lindqvist, Y]]
	[[Category: Lundqvist, T]]		[[Category: Lundqvist, T]]

OCA at 08:21, 6 January 2015

2015-01-06T08:21:47Z

← Older revision		Revision as of 08:21, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1std]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Magnaporthe_grisea Magnaporthe grisea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1STD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1std]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Magnaporthe_grisea Magnaporthe grisea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1STD FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFS:N-[1-(4-BROMOPHENYL)ETHYL]-5-FLUORO+SALICYLAMIDE'>BFS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFS:N-[1-(4-BROMOPHENYL)ETHYL]-5-FLUORO+SALICYLAMIDE'>BFS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Scytalone_dehydratase Scytalone dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.94 4.2.1.94] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Scytalone_dehydratase Scytalone dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.94 4.2.1.94] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1std FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1std OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1std RCSB], [http://www.ebi.ac.uk/pdbsum/1std PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1std FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1std OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1std RCSB], [http://www.ebi.ac.uk/pdbsum/1std PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/SCYD_MAGGR SCYD_MAGGR]] Catalyzes two steps in melanin biosynthesis. From scytalone they are two dehydration steps and one reduction step to yield melanin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	[[Category: Magnaporthe grisea]]		[[Category: Magnaporthe grisea]]
	[[Category: Scytalone dehydratase]]		[[Category: Scytalone dehydratase]]
	[[Category: Lindqvist, Y.]]		[[Category: Lindqvist, Y]]
	[[Category: Lundqvist, T.]]		[[Category: Lundqvist, T]]

OCA at 16:39, 29 September 2014

2014-09-29T16:39:32Z

← Older revision		Revision as of 16:39, 29 September 2014
Line 1:		Line 1:
	[[Image:~~1std~~.~~png~~\|~~left~~\|~~200px~~]]		==CRYSTAL STRUCTURE OF SCYTALONE DEHYDRATASE: A DISEASE DETERMINANT OF THE RICE PATHOGEN, MAGNAPORTHE GRISEA==
			<StructureSection load='1std' size='340' side='right' caption='[[1std]], [[Resolution\|resolution]] 2.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1std]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Magnaporthe_grisea Magnaporthe grisea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1STD FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFS:N-[1-(4-BROMOPHENYL)ETHYL]-5-FLUORO+SALICYLAMIDE'>BFS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Scytalone_dehydratase Scytalone dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.94 4.2.1.94] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1std FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1std OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1std RCSB], [http://www.ebi.ac.uk/pdbsum/1std PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/st/1std_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			BACKGROUND: Rice blast is caused by the pathogenic fungus,-Magnaporthe grisea. Non-pathogenic mutants have been identified that lack enzymes in the biosynthetic pathway of dihydroxynapthalene-derived melanin. These enzymes are therefore prime targets for fungicides designed to control rice blast disease. One of the enzymes identified by genetic analysis as a disease determinant is scytalone dehydratase. RESULTS: The three-dimensional structure of scytalone dehydratase in complex with a competitive inhibitor has been determined at 2.9 A resolution. A novel fold, a cone-shaped alpha + beta barrel, is adopted by the monomer in this trimeric protein, burying the hydrophobic active site in its interior. The interactions of the inhibitor with the protein side chains have been identified. The similarity of the inhibitor to the substrate and the side chains involved in binding afford some insights into possible catalytic mechanisms. CONCLUSIONS: These results provide a first look into the structure and catalytic residues of a non-metal dehydratase, a large class of hitherto structurally uncharacterized enzymes. It is envisaged that a detailed structural description of scytalone dehydratase will assist in the design of new inhibitors for controlling rice blast disease.

	~~{{STRUCTURE_1std\| PDB=1std \| SCENE= }}~~		Crystal structure of scytalone dehydratase--a disease determinant of the rice pathogen, Magnaporthe grisea.,Lundqvist T, Rice J, Hodge CN, Basarab GS, Pierce J, Lindqvist Y Structure. 1994 Oct 15;2(10):937-44. PMID:7866745<ref>PMID:7866745</ref>

	~~===CRYSTAL STRUCTURE OF SCYTALONE DEHYDRATASE: A DISEASE DETERMINANT OF THE RICE PATHOGEN~~, ~~MAGNAPORTHE GRISEA===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_7866745}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[1std]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Magnaporthe_grisea Magnaporthe grisea]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:007866745<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Magnaporthe grisea]]		[[Category: Magnaporthe grisea]]
	[[Category: Scytalone dehydratase]]		[[Category: Scytalone dehydratase]]
	[[Category: Lindqvist, Y.]]		[[Category: Lindqvist, Y.]]
	[[Category: Lundqvist, T.]]		[[Category: Lundqvist, T.]]

OCA: Protected "1std" [edit=sysop:move=sysop]

2013-01-04T10:44:12Z

Protected "1std" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:44, 4 January 2013
(No difference)

OCA at 10:44, 4 January 2013

2013-01-04T10:44:08Z

← Older revision		Revision as of 10:44, 4 January 2013
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	~~{{Seed}}~~
	[[Image:1std.png\|left\|200px]]		[[Image:1std.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_1std", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_1std\| PDB=1std \| SCENE= }}		{{STRUCTURE_1std\| PDB=1std \| SCENE= }}

	===CRYSTAL STRUCTURE OF SCYTALONE DEHYDRATASE: A DISEASE DETERMINANT OF THE RICE PATHOGEN, MAGNAPORTHE GRISEA===		===CRYSTAL STRUCTURE OF SCYTALONE DEHYDRATASE: A DISEASE DETERMINANT OF THE RICE PATHOGEN, MAGNAPORTHE GRISEA===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_7866745}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 7866745 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_7866745}}		{{ABSTRACT_PUBMED_7866745}}

	==About this Structure==		==About this Structure==
	~~1STD~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Magnaporthe_grisea Magnaporthe grisea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA].		[[1std]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Magnaporthe_grisea Magnaporthe grisea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1STD OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~7866745~~</ref><references group="xtra"/>		<ref group="xtra">PMID:007866745</ref><references group="xtra"/>
	[[Category: Magnaporthe grisea]]		[[Category: Magnaporthe grisea]]
	[[Category: Scytalone dehydratase]]		[[Category: Scytalone dehydratase]]
	[[Category: Lindqvist, Y.]]		[[Category: Lindqvist, Y.]]
	[[Category: Lundqvist, T.]]		[[Category: Lundqvist, T.]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:48:46 2009''~~