1tk2 - Revision history

OCA at 06:31, 23 August 2023

2023-08-23T06:31:22Z

← Older revision		Revision as of 06:31, 23 August 2023
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	<StructureSection load='1tk2' size='340' side='right'caption='[[1tk2]], [[Resolution\|resolution]] 1.54Å' scene=''>		<StructureSection load='1tk2' size='340' side='right'caption='[[1tk2]], [[Resolution\|resolution]] 1.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tk2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bacillus_lentus Bacillus lentus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TK2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tk2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevibacillus_brevis Brevibacillus brevis] and [https://en.wikipedia.org/wiki/Lederbergia_lenta Lederbergia lenta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TK2 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.54Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~DPN~~:~~D-PHENYLALANINE~~'>~~DPN~~</scene>, <scene name='pdbligand=~~ORN~~:L-~~ORNITHINE~~'>~~ORN~~</scene><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;~~'>[[2xdc\|2xdc]], [[1av2\|1av2]], [[1bdw\|1bdw]], [[1c4d\|1c4d]], [[1gmk\|1gmk]], [[1grm\|1grm]], [[1jno\|1jno]], [[1kqe\|1kqe]], [[1mag\|1mag]], [[1mic\|1mic]], [[1ng8\|1ng8]], [[1nrm\|1nrm]], [[1nru\|1nru]], [[1nt5\|1nt5]], [[1jo3\|1jo3]], [[1jo4\|1jo4]], [[1nt6\|1nt6]], [[1tkq\|1tkq]], [[1w5u\|1w5u]], [[2izq\|2izq]], [[3l8l\|3l8l]], [[1al4\|1al4]], [[1alx\|1alx]], [[1alz\|1alz]]</~~div></td></tr>~~
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tk2 OCA], [https://pdbe.org/1tk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tk2 RCSB], [https://www.ebi.ac.uk/pdbsum/1tk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tk2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tk2 OCA], [https://pdbe.org/1tk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tk2 RCSB], [https://www.ebi.ac.uk/pdbsum/1tk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tk2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~SUBS_BACLE SUBS_BACLE]~~] Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides.		[https://www.uniprot.org/uniprot/SUBS_LEDLE SUBS_LEDLE] Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus lentus~~]]		[[Category: Brevibacillus brevis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Subtilisin~~]]		[[Category: Lederbergia lenta]]
	[[Category: Betzel, C]]		[[Category: Betzel C]]
	[[Category: Bhatt~~, V S~~]]		[[Category: Bhatt VS]]
	[[Category: Brenner, S]]		[[Category: Brenner S]]
	[[Category: Kaur, P]]		[[Category: Kaur P]]
	[[Category: Klupsch, S]]		[[Category: Klupsch S]]
	[[Category: Singh~~, T P]]~~		[[Category: Singh TP]]
	~~[[Category: Antibacterial]]~~
	~~[[Category: Antibiotic]]~~
	~~[[Category: Antifungal]]~~
	~~[[Category: Cyclic gramicidin]]~~
	~~[[Category: Gramicidin]]~~
	~~[[Category: Hydrolase-antibiotic complex]]~~
	~~[[Category: Membrane ion channel~~]]

OCA at 09:28, 29 September 2021

2021-09-29T09:28:53Z

← Older revision		Revision as of 09:28, 29 September 2021
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	<StructureSection load='1tk2' size='340' side='right'caption='[[1tk2]], [[Resolution\|resolution]] 1.54Å' scene=''>		<StructureSection load='1tk2' size='340' side='right'caption='[[1tk2]], [[Resolution\|resolution]] 1.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tk2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bacillus_lentus Bacillus lentus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TK2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tk2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_lentus Bacillus lentus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TK2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdc\|2xdc]], [[1av2\|1av2]], [[1bdw\|1bdw]], [[1c4d\|1c4d]], [[1gmk\|1gmk]], [[1grm\|1grm]], [[1jno\|1jno]], [[1kqe\|1kqe]], [[1mag\|1mag]], [[1mic\|1mic]], [[1ng8\|1ng8]], [[1nrm\|1nrm]], [[1nru\|1nru]], [[1nt5\|1nt5]], [[1jo3\|1jo3]], [[1jo4\|1jo4]], [[1nt6\|1nt6]], [[1tkq\|1tkq]], [[1w5u\|1w5u]], [[2izq\|2izq]], [[3l8l\|3l8l]], [[1al4\|1al4]], [[1alx\|1alx]], [[1alz\|1alz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xdc\|2xdc]], [[1av2\|1av2]], [[1bdw\|1bdw]], [[1c4d\|1c4d]], [[1gmk\|1gmk]], [[1grm\|1grm]], [[1jno\|1jno]], [[1kqe\|1kqe]], [[1mag\|1mag]], [[1mic\|1mic]], [[1ng8\|1ng8]], [[1nrm\|1nrm]], [[1nru\|1nru]], [[1nt5\|1nt5]], [[1jo3\|1jo3]], [[1jo4\|1jo4]], [[1nt6\|1nt6]], [[1tkq\|1tkq]], [[1w5u\|1w5u]], [[2izq\|2izq]], [[3l8l\|3l8l]], [[1al4\|1al4]], [[1alx\|1alx]], [[1alz\|1alz]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tk2 OCA], [~~http~~://pdbe.org/1tk2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tk2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tk2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tk2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tk2 OCA], [https://pdbe.org/1tk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tk2 RCSB], [https://www.ebi.ac.uk/pdbsum/1tk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tk2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/SUBS_BACLE SUBS_BACLE]] Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides.		[[https://www.uniprot.org/uniprot/SUBS_BACLE SUBS_BACLE]] Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Gramicidin\|Gramicidin]]		*[[Gramicidin\|Gramicidin]]
	*[[Subtilisin\|Subtilisin]]		*[[Subtilisin 3D structures\|Subtilisin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:37, 25 December 2019

2019-12-25T13:37:09Z

← Older revision		Revision as of 13:37, 25 December 2019
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	==Crystal Structure of the Complex formed between Alkaline Proteinase Savinase and Gramicidin S at 1.5A Resolution==		==Crystal Structure of the Complex formed between Alkaline Proteinase Savinase and Gramicidin S at 1.5A Resolution==
	<StructureSection load='1tk2' size='340' side='right' caption='[[1tk2]], [[Resolution\|resolution]] 1.54Å' scene=''>		<StructureSection load='1tk2' size='340' side='right'caption='[[1tk2]], [[Resolution\|resolution]] 1.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_lentus Bacillus lentus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TK2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_lentus Bacillus lentus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TK2 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus lentus]]		[[Category: Bacillus lentus]]
			[[Category: Large Structures]]
	[[Category: Subtilisin]]		[[Category: Subtilisin]]
	[[Category: Betzel, C]]		[[Category: Betzel, C]]

OCA at 08:28, 21 March 2018

2018-03-21T08:28:41Z

← Older revision		Revision as of 08:28, 21 March 2018
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	==Crystal Structure of the Complex formed between Alkaline Proteinase Savinase and Gramicidin S at 1.5A Resolution==		==Crystal Structure of the Complex formed between Alkaline Proteinase Savinase and Gramicidin S at 1.5A Resolution==
	<StructureSection load='1tk2' size='340' side='right' caption='[[1tk2]], [[Resolution\|resolution]] 1.54Å' scene=''>		<StructureSection load='1tk2' size='340' side='right' caption='[[1tk2]], [[Resolution\|resolution]] 1.54Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdc\|2xdc]], [[1av2\|1av2]], [[1bdw\|1bdw]], [[1c4d\|1c4d]], [[1gmk\|1gmk]], [[1grm\|1grm]], [[1jno\|1jno]], [[1kqe\|1kqe]], [[1mag\|1mag]], [[1mic\|1mic]], [[1ng8\|1ng8]], [[1nrm\|1nrm]], [[1nru\|1nru]], [[1nt5\|1nt5]], [[1jo3\|1jo3]], [[1jo4\|1jo4]], [[1nt6\|1nt6]], [[1tkq\|1tkq]], [[1w5u\|1w5u]], [[2izq\|2izq]], [[3l8l\|3l8l]], [[1al4\|1al4]], [[1alx\|1alx]], [[1alz\|1alz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdc\|2xdc]], [[1av2\|1av2]], [[1bdw\|1bdw]], [[1c4d\|1c4d]], [[1gmk\|1gmk]], [[1grm\|1grm]], [[1jno\|1jno]], [[1kqe\|1kqe]], [[1mag\|1mag]], [[1mic\|1mic]], [[1ng8\|1ng8]], [[1nrm\|1nrm]], [[1nru\|1nru]], [[1nt5\|1nt5]], [[1jo3\|1jo3]], [[1jo4\|1jo4]], [[1nt6\|1nt6]], [[1tkq\|1tkq]], [[1w5u\|1w5u]], [[2izq\|2izq]], [[3l8l\|3l8l]], [[1al4\|1al4]], [[1alx\|1alx]], [[1alz\|1alz]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tk2 OCA], [http://pdbe.org/1tk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tk2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tk2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tk2 OCA], [http://pdbe.org/1tk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tk2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tk2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tk/1tk2_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tk/1tk2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tk2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 14:22, 11 September 2015

2015-09-11T14:22:00Z

← Older revision		Revision as of 14:22, 11 September 2015
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdc\|2xdc]], [[1av2\|1av2]], [[1bdw\|1bdw]], [[1c4d\|1c4d]], [[1gmk\|1gmk]], [[1grm\|1grm]], [[1jno\|1jno]], [[1kqe\|1kqe]], [[1mag\|1mag]], [[1mic\|1mic]], [[1ng8\|1ng8]], [[1nrm\|1nrm]], [[1nru\|1nru]], [[1nt5\|1nt5]], [[1jo3\|1jo3]], [[1jo4\|1jo4]], [[1nt6\|1nt6]], [[1tkq\|1tkq]], [[1w5u\|1w5u]], [[2izq\|2izq]], [[3l8l\|3l8l]], [[1al4\|1al4]], [[1alx\|1alx]], [[1alz\|1alz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdc\|2xdc]], [[1av2\|1av2]], [[1bdw\|1bdw]], [[1c4d\|1c4d]], [[1gmk\|1gmk]], [[1grm\|1grm]], [[1jno\|1jno]], [[1kqe\|1kqe]], [[1mag\|1mag]], [[1mic\|1mic]], [[1ng8\|1ng8]], [[1nrm\|1nrm]], [[1nru\|1nru]], [[1nt5\|1nt5]], [[1jo3\|1jo3]], [[1jo4\|1jo4]], [[1nt6\|1nt6]], [[1tkq\|1tkq]], [[1w5u\|1w5u]], [[2izq\|2izq]], [[3l8l\|3l8l]], [[1al4\|1al4]], [[1alx\|1alx]], [[1alz\|1alz]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tk2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tk2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tk2 OCA], [http://pdbe.org/1tk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tk2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tk2 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 17:38, 25 December 2014

2014-12-25T17:38:52Z

← Older revision		Revision as of 17:38, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_lentus Bacillus lentus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TK2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_lentus Bacillus lentus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TK2 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdc\|2xdc]], [[1av2\|1av2]], [[1bdw\|1bdw]], [[1c4d\|1c4d]], [[1gmk\|1gmk]], [[1grm\|1grm]], [[1jno\|1jno]], [[1kqe\|1kqe]], [[1mag\|1mag]], [[1mic\|1mic]], [[1ng8\|1ng8]], [[1nrm\|1nrm]], [[1nru\|1nru]], [[1nt5\|1nt5]], [[1jo3\|1jo3]], [[1jo4\|1jo4]], [[1nt6\|1nt6]], [[1tkq\|1tkq]], [[1w5u\|1w5u]], [[2izq\|2izq]], [[3l8l\|3l8l]], [[1al4\|1al4]], [[1alx\|1alx]], [[1alz\|1alz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdc\|2xdc]], [[1av2\|1av2]], [[1bdw\|1bdw]], [[1c4d\|1c4d]], [[1gmk\|1gmk]], [[1grm\|1grm]], [[1jno\|1jno]], [[1kqe\|1kqe]], [[1mag\|1mag]], [[1mic\|1mic]], [[1ng8\|1ng8]], [[1nrm\|1nrm]], [[1nru\|1nru]], [[1nt5\|1nt5]], [[1jo3\|1jo3]], [[1jo4\|1jo4]], [[1nt6\|1nt6]], [[1tkq\|1tkq]], [[1w5u\|1w5u]], [[2izq\|2izq]], [[3l8l\|3l8l]], [[1al4\|1al4]], [[1alx\|1alx]], [[1alz\|1alz]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tk2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tk2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tk2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tk2 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/SUBS_BACLE SUBS_BACLE]] Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 29:
	[[Category: Bacillus lentus]]		[[Category: Bacillus lentus]]
	[[Category: Subtilisin]]		[[Category: Subtilisin]]
	[[Category: Betzel, C.]]		[[Category: Betzel, C]]
	[[Category: Bhatt, V S.]]		[[Category: Bhatt, V S]]
	[[Category: Brenner, S.]]		[[Category: Brenner, S]]
	[[Category: Kaur, P.]]		[[Category: Kaur, P]]
	[[Category: Klupsch, S.]]		[[Category: Klupsch, S]]
	[[Category: Singh, T P.]]		[[Category: Singh, T P]]
	[[Category: Antibacterial]]		[[Category: Antibacterial]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]

OCA at 22:43, 28 September 2014

2014-09-28T22:43:35Z

← Older revision		Revision as of 22:43, 28 September 2014
Line 1:		Line 1:
	~~[[Image:1tk2.png\|left\|200px]]~~		==Crystal Structure of the Complex formed between Alkaline Proteinase Savinase and Gramicidin S at 1.5A Resolution==
			<StructureSection load='1tk2' size='340' side='right' caption='[[1tk2]], [[Resolution\|resolution]] 1.54Å' scene=''>
	~~{{STRUCTURE_1tk2\| PDB=1tk2 \| SCENE= }}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[1tk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_lentus Bacillus lentus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TK2 FirstGlance]. <br>
	===Crystal Structure of the Complex formed between Alkaline Proteinase Savinase and Gramicidin S at 1.5A Resolution===		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
			<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xdc\|2xdc]], [[1av2\|1av2]], [[1bdw\|1bdw]], [[1c4d\|1c4d]], [[1gmk\|1gmk]], [[1grm\|1grm]], [[1jno\|1jno]], [[1kqe\|1kqe]], [[1mag\|1mag]], [[1mic\|1mic]], [[1ng8\|1ng8]], [[1nrm\|1nrm]], [[1nru\|1nru]], [[1nt5\|1nt5]], [[1jo3\|1jo3]], [[1jo4\|1jo4]], [[1nt6\|1nt6]], [[1tkq\|1tkq]], [[1w5u\|1w5u]], [[2izq\|2izq]], [[3l8l\|3l8l]], [[1al4\|1al4]], [[1alx\|1alx]], [[1alz\|1alz]]</td></tr>
	==~~About this Structure~~==		<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>
	[[1tk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_lentus Bacillus lentus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK2 OCA].		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tk2 RCSB], [http://www.ebi.ac.uk/pdbsum/1tk2 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tk/1tk2_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Gramicidin\|Gramicidin]]		*[[Gramicidin\|Gramicidin]]
	*[[Subtilisin\|Subtilisin]]		*[[Subtilisin\|Subtilisin]]
			__TOC__
			</StructureSection>
	[[Category: Bacillus lentus]]		[[Category: Bacillus lentus]]
	[[Category: Subtilisin]]		[[Category: Subtilisin]]

OCA at 19:33, 20 October 2012

2012-10-20T19:33:08Z

← Older revision		Revision as of 19:33, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
	[[1tk2]] is a 2 chain structure ~~of [[Gramicidin]] and [[Subtilisin]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_lentus Bacillus lentus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK2 OCA].		[[1tk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_lentus Bacillus lentus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK2 OCA].

	==See Also==		==See Also==

OCA at 07:43, 27 July 2012

2012-07-27T07:43:20Z

← Older revision		Revision as of 07:43, 27 July 2012
Line 1:		Line 1:
	[[Image:1tk2.png\|left\|200px]]		[[Image:1tk2.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_1tk2", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_1tk2\| PDB=1tk2 \| SCENE= }}		{{STRUCTURE_1tk2\| PDB=1tk2 \| SCENE= }}

Line 16:		Line 10:

	==See Also==		==See Also==
	*[[Gramicidin]]		*[[Gramicidin\|Gramicidin]]
	*[[Subtilisin]]		*[[Subtilisin\|Subtilisin]]
	[[Category: Bacillus lentus]]		[[Category: Bacillus lentus]]
	[[Category: Subtilisin]]		[[Category: Subtilisin]]

OCA at 04:54, 27 July 2011

2011-07-27T04:54:16Z

← Older revision		Revision as of 04:54, 27 July 2011
Line 13:		Line 13:

	==About this Structure==		==About this Structure==
	[[1tk2]] is a 2 chain structure of [[Subtilisin]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_lentus Bacillus lentus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK2 OCA].		[[1tk2]] is a 2 chain structure of [[Gramicidin]] and [[Subtilisin]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_lentus Bacillus lentus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK2 OCA].

	==See Also==		==See Also==
			*[[Gramicidin]]
	*[[Subtilisin]]		*[[Subtilisin]]
	[[Category: Bacillus lentus]]		[[Category: Bacillus lentus]]
Line 25:		Line 26:
	[[Category: Klupsch, S.]]		[[Category: Klupsch, S.]]
	[[Category: Singh, T P.]]		[[Category: Singh, T P.]]
	[[Category: ~~1 5a resolution~~]]		[[Category: Antibacterial]]
	[[Category: ~~Complex~~]]		[[Category: Antibiotic]]
	[[Category: ~~Crystal strucure~~]]		[[Category: Antifungal]]
			[[Category: Cyclic gramicidin]]
	[[Category: Gramicidin]]		[[Category: Gramicidin]]
	[[Category: Hydrolase]]		[[Category: Hydrolase-antibiotic complex]]
	[[Category: ~~Savinase~~]]		[[Category: Membrane ion channel]]