1v6p - Revision history

OCA at 00:35, 21 November 2024

2024-11-21T00:35:41Z

← Older revision		Revision as of 00:35, 21 November 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v6/1v6p_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v6/1v6p_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 23:58, 27 December 2023

2023-12-27T23:58:34Z

← Older revision		Revision as of 23:58, 27 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v6p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V6P FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v6p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V6P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 0.87Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v6p OCA], [https://pdbe.org/1v6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v6p RCSB], [https://www.ebi.ac.uk/pdbsum/1v6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v6p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v6p OCA], [https://pdbe.org/1v6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v6p RCSB], [https://www.ebi.ac.uk/pdbsum/1v6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v6p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/3S1CB_NAJAT 3S1CB_NAJAT]] Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Has a higher toxicity than cobrotoxin-b.		[https://www.uniprot.org/uniprot/3S1CB_NAJAT 3S1CB_NAJAT] Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Has a higher toxicity than cobrotoxin-b.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Naja atra]]		[[Category: Naja atra]]
	[[Category: Hao, Q]]		[[Category: Hao Q]]
	[[Category: Huang, Q]]		[[Category: Huang Q]]
	[[Category: Liu, Q]]		[[Category: Liu Q]]
	[[Category: Lou, X]]		[[Category: Lou X]]
	[[Category: Niu, L]]		[[Category: Niu L]]
	[[Category: Teng, M]]		[[Category: Teng M]]
	[[Category: Tu, X]]		[[Category: Tu X]]
	[[Category: Wang, J]]		[[Category: Wang J]]
	~~[[Category: Atomic resolution]]~~
	~~[[Category: Copper ion]]~~
	~~[[Category: Short-chain neurotoxin]]~~
	~~[[Category: Toxin~~]]

OCA at 06:26, 6 October 2021

2021-10-06T06:26:14Z

← Older revision		Revision as of 06:26, 6 October 2021
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	<StructureSection load='1v6p' size='340' side='right'caption='[[1v6p]], [[Resolution\|resolution]] 0.87Å' scene=''>		<StructureSection load='1v6p' size='340' side='right'caption='[[1v6p]], [[Resolution\|resolution]] 0.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v6p]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1V6P FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v6p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V6P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1v6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v6p OCA], [~~http~~://pdbe.org/1v6p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1v6p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1v6p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1v6p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v6p OCA], [https://pdbe.org/1v6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v6p RCSB], [https://www.ebi.ac.uk/pdbsum/1v6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v6p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/3S1CB_NAJAT 3S1CB_NAJAT]] Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Has a higher toxicity than cobrotoxin-b.		[[https://www.uniprot.org/uniprot/3S1CB_NAJAT 3S1CB_NAJAT]] Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Has a higher toxicity than cobrotoxin-b.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:15, 1 January 2020

2020-01-01T13:15:09Z

← Older revision		Revision as of 13:15, 1 January 2020
Line 1:		Line 1:

	==Crystal structure of Cobrotoxin==		==Crystal structure of Cobrotoxin==
	<StructureSection load='1v6p' size='340' side='right' caption='[[1v6p]], [[Resolution\|resolution]] 0.87Å' scene=''>		<StructureSection load='1v6p' size='340' side='right'caption='[[1v6p]], [[Resolution\|resolution]] 0.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V6P FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V6P FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Naja atra]]		[[Category: Naja atra]]
	[[Category: Hao, Q]]		[[Category: Hao, Q]]

OCA at 08:04, 28 March 2018

2018-03-28T08:04:40Z

← Older revision		Revision as of 08:04, 28 March 2018
Line 1:		Line 1:

	==Crystal structure of Cobrotoxin==		==Crystal structure of Cobrotoxin==
	<StructureSection load='1v6p' size='340' side='right' caption='[[1v6p]], [[Resolution\|resolution]] 0.87Å' scene=''>		<StructureSection load='1v6p' size='340' side='right' caption='[[1v6p]], [[Resolution\|resolution]] 0.87Å' scene=''>
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	<table><tr><td colspan='2'>[[1v6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V6P FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V6P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v6p OCA], [http://pdbe.org/1v6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v6p RCSB], [http://www.ebi.ac.uk/pdbsum/1v6p PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v6p OCA], [http://pdbe.org/1v6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v6p RCSB], [http://www.ebi.ac.uk/pdbsum/1v6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1v6p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v6/1v6p_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v6/1v6p_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:36, 8 February 2016

2016-02-08T20:36:44Z

← Older revision		Revision as of 20:36, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v6p ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:11, 10 September 2015

2015-09-10T15:11:16Z

← Older revision		Revision as of 15:11, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1v6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V6P FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V6P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v6p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v6p RCSB], [http://www.ebi.ac.uk/pdbsum/1v6p PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v6p OCA], [http://pdbe.org/1v6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v6p RCSB], [http://www.ebi.ac.uk/pdbsum/1v6p PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/3S1CB_NAJAT 3S1CB_NAJAT]] Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Has a higher toxicity than cobrotoxin-b.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1v6p" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:58, 6 January 2015

2015-01-06T12:58:00Z

← Older revision		Revision as of 12:58, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1v6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V6P FirstGlance]. <br>		<table><tr><td colspan='2'>[[1v6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V6P FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v6p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v6p RCSB], [http://www.ebi.ac.uk/pdbsum/1v6p PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v6p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v6p RCSB], [http://www.ebi.ac.uk/pdbsum/1v6p PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Naja atra]]		[[Category: Naja atra]]
	[[Category: Hao, Q.]]		[[Category: Hao, Q]]
	[[Category: Huang, Q.]]		[[Category: Huang, Q]]
	[[Category: Liu, Q.]]		[[Category: Liu, Q]]
	[[Category: Lou, X.]]		[[Category: Lou, X]]
	[[Category: Niu, L.]]		[[Category: Niu, L]]
	[[Category: Teng, M.]]		[[Category: Teng, M]]
	[[Category: Tu, X.]]		[[Category: Tu, X]]
	[[Category: Wang, J.]]		[[Category: Wang, J]]
	[[Category: Atomic resolution]]		[[Category: Atomic resolution]]
	[[Category: Copper ion]]		[[Category: Copper ion]]
	~~[[Category: Naja atra]]~~
	[[Category: Short-chain neurotoxin]]		[[Category: Short-chain neurotoxin]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 21:34, 29 September 2014

2014-09-29T21:34:19Z

← Older revision		Revision as of 21:34, 29 September 2014
Line 1:		Line 1:
	[[Image:~~1v6p~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of Cobrotoxin==
			<StructureSection load='1v6p' size='340' side='right' caption='[[1v6p]], [[Resolution\|resolution]] 0.87Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1v6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V6P FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v6p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v6p RCSB], [http://www.ebi.ac.uk/pdbsum/1v6p PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v6/1v6p_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			By using single wavelength anomalous diffraction phasing based on the anomalous signal from copper atoms, the crystal structure of atratoxin was determined at the resolution of 1.5 A and was refined to an ultrahigh resolution of 0.87 A. The ultrahigh resolution electron density maps allowed the modeling of 38 amino acid residues in alternate conformations and the location of 322 of 870 possible hydrogen atoms. To get accurate information at the atomic level, atratoxin-b (an analog of atratoxin with reduced toxicity) was also refined to an atomic resolution of 0.92 A. By the sequence and structural comparison of these two atratoxins, Arg(33) and Arg(36) were identified to be critical to their varied toxicity. The effect of copper ions on the distribution of hydrogen atoms in atratoxin was discussed, and the interactions between copper ions and protein residues were analyzed based on a statistical method, revealing a novel pentahedral copper-binding motif.

	~~{{STRUCTURE_1v6p\| PDB=1v6p \| SCENE= }}~~		The atomic resolution crystal structure of atratoxin determined by single wavelength anomalous diffraction phasing.,Lou X, Liu Q, Tu X, Wang J, Teng M, Niu L, Schuller DJ, Huang Q, Hao Q J Biol Chem. 2004 Sep 10;279(37):39094-104. Epub 2004 Jul 12. PMID:15252034<ref>PMID:15252034</ref>

	~~===Crystal structure~~ of ~~Cobrotoxin===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_15252034}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[1v6p]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Naja_atra Naja atra]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1V6P OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:015252034<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Naja atra]]		[[Category: Naja atra]]
	[[Category: Hao, Q.]]		[[Category: Hao, Q.]]

OCA: Protected "1v6p" [edit=sysop:move=sysop]

2013-01-05T12:53:41Z

Protected "1v6p" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:53, 5 January 2013
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