1xml - Revision history

OCA at 07:55, 15 May 2024

2024-05-15T07:55:50Z

← Older revision		Revision as of 07:55, 15 May 2024
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	<StructureSection load='1xml' size='340' side='right'caption='[[1xml]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1xml' size='340' side='right'caption='[[1xml]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xml]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XML FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xml]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XML FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1xmm\|1xmm]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xml OCA], [https://pdbe.org/1xml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xml RCSB], [https://www.ebi.ac.uk/pdbsum/1xml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xml ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xml OCA], [https://pdbe.org/1xml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xml RCSB], [https://www.ebi.ac.uk/pdbsum/1xml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xml ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/DCPS_HUMAN DCPS_HUMAN] Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.<ref>PMID:12198172</ref> <ref>PMID:12871939</ref> <ref>PMID:11747811</ref> <ref>PMID:14523240</ref> <ref>PMID:15273322</ref> <ref>PMID:15383679</ref> <ref>PMID:16140270</ref> <ref>PMID:18426921</ref> <ref>PMID:22985415</ref> <ref>PMID:15769464</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chen, N]]		[[Category: Chen N]]
	[[Category: Song, H]]		[[Category: Song H]]
	~~[[Category: Chaperone]]~~
	~~[[Category: Scavenger decapping enzyme~~]]

OCA at 16:39, 27 October 2021

2021-10-27T16:39:54Z

← Older revision		Revision as of 16:39, 27 October 2021
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	<StructureSection load='1xml' size='340' side='right'caption='[[1xml]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1xml' size='340' side='right'caption='[[1xml]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xml]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XML OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1XML FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xml]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XML FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmm\|1xmm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xmm\|1xmm]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xml OCA], [~~http~~://pdbe.org/1xml PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1xml RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1xml PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1xml ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xml OCA], [https://pdbe.org/1xml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xml RCSB], [https://www.ebi.ac.uk/pdbsum/1xml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xml ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 17:57, 22 January 2020

2020-01-22T17:57:12Z

← Older revision		Revision as of 17:57, 22 January 2020
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	==Structure of human Dcps==		==Structure of human Dcps==
	<StructureSection load='1xml' size='340' side='right' caption='[[1xml]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1xml' size='340' side='right'caption='[[1xml]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XML FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XML FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Chen, N]]		[[Category: Chen, N]]
	[[Category: Song, H]]		[[Category: Song, H]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Scavenger decapping enzyme]]		[[Category: Scavenger decapping enzyme]]

OCA at 07:34, 18 April 2018

2018-04-18T07:34:11Z

← Older revision		Revision as of 07:34, 18 April 2018
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	==Structure of human Dcps==		==Structure of human Dcps==
	<StructureSection load='1xml' size='340' side='right' caption='[[1xml]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1xml' size='340' side='right' caption='[[1xml]], [[Resolution\|resolution]] 2.00Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmm\|1xmm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmm\|1xmm]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xml OCA], [http://pdbe.org/1xml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xml RCSB], [http://www.ebi.ac.uk/pdbsum/1xml PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xml OCA], [http://pdbe.org/1xml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xml RCSB], [http://www.ebi.ac.uk/pdbsum/1xml PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xml ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xm/1xml_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xm/1xml_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:58, 8 February 2016

2016-02-08T04:58:59Z

← Older revision		Revision as of 04:58, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xml ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:06, 10 September 2015

2015-09-10T08:06:53Z

← Older revision		Revision as of 08:06, 10 September 2015
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	<StructureSection load='1xml' size='340' side='right' caption='[[1xml]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1xml' size='340' side='right' caption='[[1xml]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XML FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XML FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmm\|1xmm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmm\|1xmm]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xml RCSB], [http://www.ebi.ac.uk/pdbsum/1xml PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xml OCA], [http://pdbe.org/1xml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xml RCSB], [http://www.ebi.ac.uk/pdbsum/1xml PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1xml" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Chen, N]]		[[Category: Chen, N]]
	[[Category: Song, H]]		[[Category: Song, H]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Scavenger decapping enzyme]]		[[Category: Scavenger decapping enzyme]]

OCA at 14:00, 6 January 2015

2015-01-06T14:00:15Z

← Older revision		Revision as of 14:00, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1xml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XML FirstGlance]. <br>		<table><tr><td colspan='2'>[[1xml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XML FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmm\|1xmm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmm\|1xmm]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xml RCSB], [http://www.ebi.ac.uk/pdbsum/1xml PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xml RCSB], [http://www.ebi.ac.uk/pdbsum/1xml PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, N.]]		[[Category: Chen, N]]
	[[Category: Song, H.]]		[[Category: Song, H]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Scavenger decapping enzyme]]		[[Category: Scavenger decapping enzyme]]

OCA at 21:08, 29 September 2014

2014-09-29T21:08:28Z

← Older revision		Revision as of 21:08, 29 September 2014
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	[[Image:~~1xml~~.~~png~~\|~~left~~\|~~200px~~]]		==Structure of human Dcps==
			<StructureSection load='1xml' size='340' side='right' caption='[[1xml]], [[Resolution\|resolution]] 2.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1xml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XML FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmm\|1xmm]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xml RCSB], [http://www.ebi.ac.uk/pdbsum/1xml PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xm/1xml_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Eukaryotic cells utilize DcpS, a scavenger decapping enzyme, to degrade the residual cap structure following 3'-5' mRNA decay, thereby preventing the premature decapping of the capped long mRNA and misincorporation of methylated nucleotides in nucleic acids. We report the structures of DcpS in ligand-free form and in a complex with m7GDP. apo-DcpS is a symmetric dimer, strikingly different from the asymmetric dimer observed in the structures of DcpS with bound cap analogues. In contrast, and similar to the m7GpppG-DcpS complex, DcpS with bound m7GDP is an asymmetric dimer in which the closed state appears to be the substrate-bound complex, whereas the open state mimics the product-bound complex. Comparisons of these structures revealed conformational changes of both the N-terminal swapped-dimeric domain and the cap-binding pocket upon cap binding. Moreover, Tyr273 in the cap-binding pocket displays remarkable conformational changes upon cap binding. Mutagenesis and biochemical analysis suggest that Tyr273 seems to play an important role in cap binding and product release. Examination of the crystallographic B-factors indicates that the N-terminal domain in apo-DcpS is inherently flexible, and in a dynamic state ready for substrate binding and product release.

	~~{{STRUCTURE_1xml\| PDB=1xml \| SCENE= }}~~		Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.,Chen N, Walsh MA, Liu Y, Parker R, Song H J Mol Biol. 2005 Apr 8;347(4):707-18. PMID:15769464<ref>PMID:15769464</ref>

	~~===Structure~~ of ~~human Dcps===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_15769464}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[1xml]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1XML OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:015769464<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, N.]]		[[Category: Chen, N.]]

OCA: Protected "1xml" [edit=sysop:move=sysop]

2013-01-05T12:11:26Z

Protected "1xml" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:11, 5 January 2013
(No difference)

OCA at 12:11, 5 January 2013

2013-01-05T12:11:21Z

← Older revision		Revision as of 12:11, 5 January 2013
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	~~{{Seed}}~~
	[[Image:1xml.png\|left\|200px]]		[[Image:1xml.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_1xml", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_1xml\| PDB=1xml \| SCENE= }}		{{STRUCTURE_1xml\| PDB=1xml \| SCENE= }}

	===Structure of human Dcps===		===Structure of human Dcps===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_15769464}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 15769464 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_15769464}}		{{ABSTRACT_PUBMED_15769464}}

	==About this Structure==		==About this Structure==
	~~1XML~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XML OCA].		[[1xml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XML OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~15769464~~</ref><references group="xtra"/>		<ref group="xtra">PMID:015769464</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, N.]]		[[Category: Chen, N.]]
	[[Category: Song, H.]]		[[Category: Song, H.]]
			[[Category: Chaperone]]
	[[Category: Scavenger decapping enzyme]]		[[Category: Scavenger decapping enzyme]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:58:54 2009''~~