1zig - Revision history

OCA at 09:31, 6 December 2023

2023-12-06T09:31:46Z

← Older revision		Revision as of 09:31, 6 December 2023
Line 1:		Line 1:

	==GAGA RNA TETRALOOP, NMR, 10 STRUCTURES==		==GAGA RNA TETRALOOP, NMR, 10 STRUCTURES==
	<StructureSection load='1zig' size='340' side='right'caption='[[1zig~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>		<StructureSection load='1zig' size='340' side='right'caption='[[1zig]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zig]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZIG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zig]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZIG FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1zif\|1zif]], [[1zih\|1zih]]</div~~></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zig OCA], [https://pdbe.org/1zig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zig RCSB], [https://www.ebi.ac.uk/pdbsum/1zig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zig ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zig OCA], [https://pdbe.org/1zig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zig RCSB], [https://www.ebi.ac.uk/pdbsum/1zig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zig ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Heus~~, H A~~]]		[[Category: Heus HA]]
	[[Category: Jucker~~, F M~~]]		[[Category: Jucker FM]]
	[[Category: Moors, E]]		[[Category: Moors E]]
	[[Category: Pardi, A]]		[[Category: Pardi A]]
	[[Category: Yip~~, P F]]~~		[[Category: Yip PF]]
	~~[[Category: Gnra]]~~
	~~[[Category: Hairpin]]~~
	~~[[Category: Ribonucleic acid]]~~
	~~[[Category: Rna]]~~
	~~[[Category: Tetraloop~~]]

OCA at 08:21, 10 November 2021

2021-11-10T08:21:32Z

← Older revision		Revision as of 08:21, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='1zig' size='340' side='right'caption='[[1zig]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1zig' size='340' side='right'caption='[[1zig]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zig]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZIG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zig]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZIG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zif\|1zif]], [[1zih\|1zih]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zif\|1zif]], [[1zih\|1zih]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zig OCA], [~~http~~://pdbe.org/1zig PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zig RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zig PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zig ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zig OCA], [https://pdbe.org/1zig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zig RCSB], [https://www.ebi.ac.uk/pdbsum/1zig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zig ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:21, 5 February 2020

2020-02-05T09:21:14Z

← Older revision		Revision as of 09:21, 5 February 2020
Line 1:		Line 1:

	==GAGA RNA TETRALOOP, NMR, 10 STRUCTURES==		==GAGA RNA TETRALOOP, NMR, 10 STRUCTURES==
	<StructureSection load='1zig' size='340' side='right' caption='[[1zig]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1zig' size='340' side='right'caption='[[1zig]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zig]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zig]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIG FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Heus, H A]]		[[Category: Heus, H A]]
	[[Category: Jucker, F M]]		[[Category: Jucker, F M]]

OCA at 08:47, 2 May 2018

2018-05-02T08:47:42Z

← Older revision		Revision as of 08:47, 2 May 2018
Line 1:		Line 1:

	==GAGA RNA TETRALOOP, NMR, 10 STRUCTURES==		==GAGA RNA TETRALOOP, NMR, 10 STRUCTURES==
	<StructureSection load='1zig' size='340' side='right' caption='[[1zig]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='1zig' size='340' side='right' caption='[[1zig]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1zig]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zig]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zif\|1zif]], [[1zih\|1zih]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zif\|1zif]], [[1zih\|1zih]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zig OCA], [http://pdbe.org/1zig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zig RCSB], [http://www.ebi.ac.uk/pdbsum/1zig PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zig OCA], [http://pdbe.org/1zig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zig RCSB], [http://www.ebi.ac.uk/pdbsum/1zig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zig ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:52, 10 September 2015

2015-09-10T19:52:55Z

← Older revision		Revision as of 19:52, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1zig]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zig]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zif\|1zif]], [[1zih\|1zih]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zif\|1zif]], [[1zih\|1zih]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zig OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zig RCSB], [http://www.ebi.ac.uk/pdbsum/1zig PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zig OCA], [http://pdbe.org/1zig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zig RCSB], [http://www.ebi.ac.uk/pdbsum/1zig PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1zig" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:35, 3 January 2015

2015-01-03T22:35:10Z

← Older revision		Revision as of 22:35, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zig]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zig]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIG FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zif\|1zif]], [[1zih\|1zih]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zif\|1zif]], [[1zih\|1zih]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zig OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zig RCSB], [http://www.ebi.ac.uk/pdbsum/1zig PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zig OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zig RCSB], [http://www.ebi.ac.uk/pdbsum/1zig PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Heus, H A.]]		[[Category: Heus, H A]]
	[[Category: Jucker, F M.]]		[[Category: Jucker, F M]]
	[[Category: Moors, E.]]		[[Category: Moors, E]]
	[[Category: Pardi, A.]]		[[Category: Pardi, A]]
	[[Category: Yip, P F.]]		[[Category: Yip, P F]]
	[[Category: Gnra]]		[[Category: Gnra]]
	[[Category: Hairpin]]		[[Category: Hairpin]]

OCA at 06:47, 9 June 2014

2014-06-09T06:47:53Z

← Older revision		Revision as of 06:47, 9 June 2014
Line 1:		Line 1:
	[[~~Image~~:~~1zig~~.~~png~~\|~~left~~\|~~200px~~]]		==GAGA RNA TETRALOOP, NMR, 10 STRUCTURES==
			<StructureSection load='1zig' size='340' side='right' caption='[[1zig]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1zig]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZIG FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zif\|1zif]], [[1zih\|1zih]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zig OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zig RCSB], [http://www.ebi.ac.uk/pdbsum/1zig PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			RNA hairpin loops containing a GNRA consensus sequence are the most frequently occurring hairpins in a variety of prokaryotic and eukaryotic RNAs. These tetraloops play important functional roles in RNA folding, in RNA-RNA tertiary interactions and as protein binding sites. Homo and heteronuclear NMR spectroscopy have been used to determine the structures of the most abundant members of the GNRA tetraloop family: the GAGA, GCAA and GAAA loops closed by a C-G base pair. Analysis of the structures of these three hairpin loops reveals a network of heterogeneous hydrogen bonds. The loops contain a G-A base pair, a G base-phosphate hydrogen bond and several 2' OH-base hydrogen bonds. These intramolecular interactions and the extensive base stacking in the loop help explain the high thermodynamic stability and give insight into the diverse biological roles of the GNRA RNA hairpins.

	~~{{STRUCTURE_1zig\| PDB=1zig \| SCENE= }}~~		A network of heterogeneous hydrogen bonds in GNRA tetraloops.,Jucker FM, Heus HA, Yip PF, Moors EH, Pardi A J Mol Biol. 1996 Dec 20;264(5):968-80. PMID:9000624<ref>PMID:9000624</ref>

	~~===GAGA RNA TETRALOOP, NMR~~, ~~10 STRUCTURES===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_9000624}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[1zig]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1ZIG OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:009000624<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Heus, H A.]]		[[Category: Heus, H A.]]
	[[Category: Jucker, F M.]]		[[Category: Jucker, F M.]]

OCA: Protected "1zig" [edit=sysop:move=sysop]

2012-08-14T17:22:15Z

Protected "1zig" [edit=sysop:move=sysop]

← Older revision	Revision as of 17:22, 14 August 2012
(No difference)

OCA at 17:22, 14 August 2012

2012-08-14T17:22:13Z

← Older revision		Revision as of 17:22, 14 August 2012
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:1zig.png\|left\|200px]]		[[Image:1zig.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_1zig", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_1zig\| PDB=1zig \| SCENE= }}		{{STRUCTURE_1zig\| PDB=1zig \| SCENE= }}

	===GAGA RNA TETRALOOP, NMR, 10 STRUCTURES===		===GAGA RNA TETRALOOP, NMR, 10 STRUCTURES===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_9000624}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 9000624 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_9000624}}		{{ABSTRACT_PUBMED_9000624}}

	==About this Structure==		==About this Structure==
	Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA].		[[1zig]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA].

	==Reference==		==Reference==
	~~A network of heterogeneous hydrogen bonds in GNRA tetraloops., Jucker FM, Heus HA, Yip PF, Moors EH, Pardi A, J Mol Biol. 1996 Dec 20;264(5):968-80.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~9000624 9000624]~~		<ref group="xtra">PMID:009000624</ref><references group="xtra"/>
	[[Category: Heus, H A.]]		[[Category: Heus, H A.]]
	[[Category: Jucker, F M.]]		[[Category: Jucker, F M.]]
Line 34:		Line 22:
	[[Category: Rna]]		[[Category: Rna]]
	[[Category: Tetraloop]]		[[Category: Tetraloop]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:14:49 2008''~~

OCA at 08:14, 28 July 2008

2008-07-28T08:14:51Z

← Older revision		Revision as of 08:14, 28 July 2008
Line 1:		Line 1:
	[[Image:1zig.~~gif~~\|left\|200px]]		{{Seed}}
			[[Image:1zig.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1zig\| PDB=1zig \| SCENE= }}		{{STRUCTURE_1zig\| PDB=1zig \| SCENE= }}

	~~'''~~GAGA RNA TETRALOOP, NMR, 10 STRUCTURES~~'''~~		===GAGA RNA TETRALOOP, NMR, 10 STRUCTURES===


	~~==Overview==~~		<!--
	~~RNA hairpin loops containing a GNRA consensus sequence are~~ the most frequently occurring hairpins in a variety of prokaryotic and eukaryotic RNAs. These tetraloops play important functional roles in RNA folding, in RNA-RNA tertiary interactions and as protein binding sites. Homo and heteronuclear NMR spectroscopy have been used to ~~determine~~ the ~~structures of the most abundant members of the GNRA tetraloop family~~: ~~the GAGA~~, ~~GCAA and GAAA loops closed by a C-G base pair. Analysis of~~ the ~~structures of these three hairpin loops reveals a network of heterogeneous hydrogen bonds~~. ~~The loops contain a G-A base pair, a G base~~-~~phosphate hydrogen bond and several 2' OH~~-base hydrogen bonds. These intramolecular interactions and the extensive base stacking in the loop help explain the high thermodynamic stability and give insight into the diverse biological roles of the GNRA RNA hairpins.		The line below this paragraph, {{ABSTRACT_PUBMED_9000624}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 9000624 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_9000624}}

	==About this Structure==		==About this Structure==
	Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA].		Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA].

	==Reference==		==Reference==
Line 30:		Line 34:
	[[Category: Rna]]		[[Category: Rna]]
	[[Category: Tetraloop]]		[[Category: Tetraloop]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 17~~:39:57 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:14:49 2008''