1zos - Revision history

OCA at 07:12, 23 August 2023

2023-08-23T07:12:11Z

← Older revision		Revision as of 07:12, 23 August 2023
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	<StructureSection load='1zos' size='340' side='right'caption='[[1zos]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1zos' size='340' side='right'caption='[[1zos]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zos]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Strr6 Strr6~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zos]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTM:(3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL'>MTM</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methylthioadenosine_nucleosidase Methylthioadenosine nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.16 3.2.2.16] </span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTM:(3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL'>MTM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zos OCA], [https://pdbe.org/1zos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zos RCSB], [https://www.ebi.ac.uk/pdbsum/1zos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zos OCA], [https://pdbe.org/1zos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zos RCSB], [https://www.ebi.ac.uk/pdbsum/1zos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zos ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q8DQ16_STRR6 Q8DQ16_STRR6]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Methylthioadenosine nucleosidase]]~~		[[Category: Streptococcus pneumoniae R6]]
	~~[[Category: Strr6~~]]		[[Category: Almo SC]]
	[[Category: Almo~~, S C~~]]		[[Category: Furneaux RH]]
	[[Category: Furneaux~~, R H~~]]		[[Category: Schramm VL]]
	[[Category: Schramm~~, V L~~]]		[[Category: Shi W]]
	[[Category: Shi, W]]		[[Category: Singh V]]
	[[Category: Singh, V]]		[[Category: Tyler PC]]
	[[Category: Tyler~~, P C~~]]		[[Category: Zhen R]]
	[[Category: Zhen, R]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Inhibitor]]~~
	~~[[Category: Nucleosidase]]~~
	~~[[Category: Pneumoniae]]~~
	~~[[Category: Transition state~~]]

OCA at 06:35, 6 October 2021

2021-10-06T06:35:18Z

← Older revision		Revision as of 06:35, 6 October 2021
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	<StructureSection load='1zos' size='340' side='right'caption='[[1zos]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1zos' size='340' side='right'caption='[[1zos]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zos]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zos]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTM:(3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL'>MTM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTM:(3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL'>MTM</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Methylthioadenosine_nucleosidase Methylthioadenosine nucleosidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.16 3.2.2.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methylthioadenosine_nucleosidase Methylthioadenosine nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.16 3.2.2.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zos OCA], [~~http~~://pdbe.org/1zos PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zos RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zos PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zos ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zos OCA], [https://pdbe.org/1zos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zos RCSB], [https://www.ebi.ac.uk/pdbsum/1zos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zos ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:19, 4 December 2019

2019-12-04T11:19:20Z

← Older revision		Revision as of 11:19, 4 December 2019
Line 1:		Line 1:

	==Structure of 5'-methylthionadenosine/S-Adenosylhomocysteine nucleosidase from S. pneumoniae with a transition-state inhibitor MT-ImmA==		==Structure of 5'-methylthionadenosine/S-Adenosylhomocysteine nucleosidase from S. pneumoniae with a transition-state inhibitor MT-ImmA==
	<StructureSection load='1zos' size='340' side='right' caption='[[1zos]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1zos' size='340' side='right'caption='[[1zos]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zos]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zos]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZOS FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Methylthioadenosine nucleosidase]]		[[Category: Methylthioadenosine nucleosidase]]
	[[Category: Strr6]]		[[Category: Strr6]]

OCA at 18:43, 24 January 2018

2018-01-24T18:43:12Z

← Older revision		Revision as of 18:43, 24 January 2018
Line 1:		Line 1:

	==Structure of 5'-methylthionadenosine/S-Adenosylhomocysteine nucleosidase from S. pneumoniae with a transition-state inhibitor MT-ImmA==		==Structure of 5'-methylthionadenosine/S-Adenosylhomocysteine nucleosidase from S. pneumoniae with a transition-state inhibitor MT-ImmA==
	<StructureSection load='1zos' size='340' side='right' caption='[[1zos]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1zos' size='340' side='right' caption='[[1zos]], [[Resolution\|resolution]] 1.60Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTM:(3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL'>MTM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTM:(3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL'>MTM</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylthioadenosine_nucleosidase Methylthioadenosine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.16 3.2.2.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylthioadenosine_nucleosidase Methylthioadenosine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.16 3.2.2.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zos OCA], [http://pdbe.org/1zos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zos RCSB], [http://www.ebi.ac.uk/pdbsum/1zos PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zos OCA], [http://pdbe.org/1zos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zos RCSB], [http://www.ebi.ac.uk/pdbsum/1zos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zos ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zo/1zos_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zo/1zos_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 08:39, 7 February 2016

2016-02-07T08:39:02Z

← Older revision		Revision as of 08:39, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zos ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:43, 9 September 2015

2015-09-09T23:43:01Z

← Older revision		Revision as of 23:43, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1zos' size='340' side='right' caption='[[1zos]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='1zos' size='340' side='right' caption='[[1zos]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zos]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zos]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZOS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTM:(3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL'>MTM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTM:(3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL'>MTM</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylthioadenosine_nucleosidase Methylthioadenosine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.16 3.2.2.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylthioadenosine_nucleosidase Methylthioadenosine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.16 3.2.2.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zos RCSB], [http://www.ebi.ac.uk/pdbsum/1zos PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zos OCA], [http://pdbe.org/1zos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zos RCSB], [http://www.ebi.ac.uk/pdbsum/1zos PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1zos" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Methylthioadenosine nucleosidase]]		[[Category: Methylthioadenosine nucleosidase]]
	[[Category: ~~Streptococcus pneumoniae r6~~]]		[[Category: Strr6]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]
	[[Category: Furneaux, R H]]		[[Category: Furneaux, R H]]

OCA at 10:08, 8 January 2015

2015-01-08T10:08:20Z

← Older revision		Revision as of 10:08, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zos]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZOS FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zos]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZOS FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTM:(3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL'>MTM</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTM:(3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL'>MTM</scene></td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylthioadenosine_nucleosidase Methylthioadenosine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.16 3.2.2.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylthioadenosine_nucleosidase Methylthioadenosine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.16 3.2.2.16] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zos RCSB], [http://www.ebi.ac.uk/pdbsum/1zos PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zos RCSB], [http://www.ebi.ac.uk/pdbsum/1zos PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Methylthioadenosine nucleosidase]]		[[Category: Methylthioadenosine nucleosidase]]
	[[Category: Streptococcus pneumoniae r6]]		[[Category: Streptococcus pneumoniae r6]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C]]
	[[Category: Furneaux, R H.]]		[[Category: Furneaux, R H]]
	[[Category: Schramm, V L.]]		[[Category: Schramm, V L]]
	[[Category: Shi, W.]]		[[Category: Shi, W]]
	[[Category: Singh, V.]]		[[Category: Singh, V]]
	[[Category: Tyler, P C.]]		[[Category: Tyler, P C]]
	[[Category: Zhen, R]]		[[Category: Zhen, R]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 02:32, 30 September 2014

2014-09-30T02:32:25Z

← Older revision		Revision as of 02:32, 30 September 2014
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	[[Image:~~1zos~~.~~png~~\|~~left~~\|~~200px~~]]		==Structure of 5'-methylthionadenosine/S-Adenosylhomocysteine nucleosidase from S. pneumoniae with a transition-state inhibitor MT-ImmA==
			<StructureSection load='1zos' size='340' side='right' caption='[[1zos]], [[Resolution\|resolution]] 1.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1zos]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZOS FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTM:(3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL'>MTM</scene><br>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylthioadenosine_nucleosidase Methylthioadenosine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.16 3.2.2.16] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zos OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zos RCSB], [http://www.ebi.ac.uk/pdbsum/1zos PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zo/1zos_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Streptococcus pneumoniae 5'-methylthioadenosine/S-adenosylhomocysteine hydrolase (MTAN) catalyzes the hydrolytic deadenylation of its substrates to form adenine and 5-methylthioribose or S-ribosylhomocysteine (SRH). MTAN is not found in mammals but is involved in bacterial quorum sensing. MTAN gene disruption affects the growth and pathogenicity of bacteria, making it a target for antibiotic design. Kinetic isotope effects and computational studies have established a dissociative S(N)1 transition state for Escherichia coli MTAN, and transition state analogues resembling the transition state are powerful inhibitors of the enzyme [Singh, V., Lee, J. L., Nunez, S., Howell, P. L., and Schramm, V. L. (2005) Biochemistry 44, 11647-11659]. The sequence of MTAN from S. pneumoniae is 40% identical to that of E. coli MTAN, but S. pneumoniae MTAN exhibits remarkably distinct kinetic and inhibitory properties. 5'-Methylthio-Immucillin-A (MT-ImmA) is a transition state analogue resembling an early S(N)1 transition state. It is a weak inhibitor of S. pneumoniae MTAN with a K(i) of 1.0 microM. The X-ray structure of S. pneumoniae MTAN with MT-ImmA indicates a dimer with the methylthio group in a flexible hydrophobic pocket. Replacing the methyl group with phenyl (PhT-ImmA), tolyl (p-TolT-ImmA), or ethyl (EtT-ImmA) groups increases the affinity to give K(i) values of 335, 60, and 40 nM, respectively. DADMe-Immucillins are geometric and electrostatic mimics of a fully dissociated transition state and bind more tightly than Immucillins. MT-DADMe-Immucillin-A inhibits with a K(i) value of 24 nM, and replacing the 5'-methyl group with p-Cl-phenyl (p-Cl-PhT-DADMe-ImmA) gave a K(i) value of 0.36 nM. The inhibitory potential of DADMe-Immucillins relative to the Immucillins supports a fully dissociated transition state structure for S. pneumoniae MTAN. Comparison of active site contacts in the X-ray crystal structures of E. coli and S. pneumoniae MTAN with MT-ImmA would predict equal binding, yet most analogues bind 10(3)-10(4)-fold more tightly to the E. coli enzyme. Catalytic site efficiency is primarily responsible for this difference since k(cat)/K(m) for S. pneumoniae MTAN is decreased 845-fold relative to that of E. coli MTAN.

	~~{{STRUCTURE_1zos\| PDB=1zos \| SCENE= }}~~		Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae.,Singh V, Shi W, Almo SC, Evans GB, Furneaux RH, Tyler PC, Painter GF, Lenz DH, Mee S, Zheng R, Schramm VL Biochemistry. 2006 Oct 31;45(43):12929-41. PMID:17059210<ref>PMID:17059210</ref>

	~~===Structure of 5'-methylthionadenosine~~/~~S-Adenosylhomocysteine nucleosidase from S. pneumoniae with~~ a ~~transition-state inhibitor MT-ImmA===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17059210}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[1zos]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOS OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:017059210<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Methylthioadenosine nucleosidase]]		[[Category: Methylthioadenosine nucleosidase]]
	[[Category: Streptococcus pneumoniae r6]]		[[Category: Streptococcus pneumoniae r6]]

OCA: Protected "1zos" [edit=sysop:move=sysop]

2013-01-05T17:11:49Z

Protected "1zos" [edit=sysop:move=sysop]

← Older revision	Revision as of 17:11, 5 January 2013
(No difference)

OCA at 17:11, 5 January 2013

2013-01-05T17:11:47Z

← Older revision		Revision as of 17:11, 5 January 2013
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	~~{{Seed}}~~
	[[Image:1zos.png\|left\|200px]]		[[Image:1zos.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_1zos", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_1zos\| PDB=1zos \| SCENE= }}		{{STRUCTURE_1zos\| PDB=1zos \| SCENE= }}

	===Structure of 5'-methylthionadenosine/S-Adenosylhomocysteine nucleosidase from S. pneumoniae with a transition-state inhibitor MT-ImmA===		===Structure of 5'-methylthionadenosine/S-Adenosylhomocysteine nucleosidase from S. pneumoniae with a transition-state inhibitor MT-ImmA===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17059210}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17059210 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17059210}}		{{ABSTRACT_PUBMED_17059210}}

	==About this Structure==		==About this Structure==
	~~1ZOS~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOS OCA].		[[1zos]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOS OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17059210~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017059210</ref><references group="xtra"/>
	[[Category: Methylthioadenosine nucleosidase]]		[[Category: Methylthioadenosine nucleosidase]]
	[[Category: Streptococcus pneumoniae r6]]		[[Category: Streptococcus pneumoniae r6]]
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	[[Category: Pneumoniae]]		[[Category: Pneumoniae]]
	[[Category: Transition state]]		[[Category: Transition state]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jan 18 10:59:27 2010''~~