1zza - Revision history

OCA at 09:32, 6 December 2023

2023-12-06T09:32:23Z

← Older revision		Revision as of 09:32, 6 December 2023
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	==Solution NMR Structure of the Membrane Protein Stannin==		==Solution NMR Structure of the Membrane Protein Stannin==
	<StructureSection load='1zza' size='340' side='right'caption='[[1zza~~]], [[NMR_Ensembles_of_Models \| 25 NMR models~~]]' scene=''>		<StructureSection load='1zza' size='340' side='right'caption='[[1zza]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zza]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zza]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZZA FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>SNN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zza OCA], [https://pdbe.org/1zza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zza RCSB], [https://www.ebi.ac.uk/pdbsum/1zza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zza ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zza OCA], [https://pdbe.org/1zza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zza RCSB], [https://www.ebi.ac.uk/pdbsum/1zza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zza ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/SNN_HUMAN SNN_HUMAN]] Plays a role in the toxic effects of organotins.		[https://www.uniprot.org/uniprot/SNN_HUMAN SNN_HUMAN] Plays a role in the toxic effects of organotins.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Buck-Koehntop~~, B A~~]]		[[Category: Buck-Koehntop BA]]
	[[Category: Buffy~~, J J~~]]		[[Category: Buffy JJ]]
	[[Category: Mascioni, A]]		[[Category: Mascioni A]]
	[[Category: Veglia, G]]		[[Category: Veglia G]]
	~~[[Category: Helix]]~~
	~~[[Category: Membrane protein~~]]

OCA at 08:20, 27 January 2021

2021-01-27T08:20:49Z

← Older revision		Revision as of 08:20, 27 January 2021
Line 1:		Line 1:

	==Solution NMR Structure of the Membrane Protein Stannin==		==Solution NMR Structure of the Membrane Protein Stannin==
	<StructureSection load='1zza' size='340' side='right' caption='[[1zza]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='1zza' size='340' side='right'caption='[[1zza]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zza]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zza]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZZA FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNN ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zza OCA], [~~http~~://pdbe.org/1zza PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zza RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zza PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zza ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zza OCA], [https://pdbe.org/1zza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zza RCSB], [https://www.ebi.ac.uk/pdbsum/1zza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zza ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/SNN_HUMAN SNN_HUMAN]] Plays a role in the toxic effects of organotins.		[[https://www.uniprot.org/uniprot/SNN_HUMAN SNN_HUMAN]] Plays a role in the toxic effects of organotins.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Buck-Koehntop, B A]]		[[Category: Buck-Koehntop, B A]]
	[[Category: Buffy, J J]]		[[Category: Buffy, J J]]

OCA at 08:47, 2 May 2018

2018-05-02T08:47:29Z

← Older revision		Revision as of 08:47, 2 May 2018
Line 1:		Line 1:

	==Solution NMR Structure of the Membrane Protein Stannin==		==Solution NMR Structure of the Membrane Protein Stannin==
	<StructureSection load='1zza' size='340' side='right' caption='[[1zza]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='1zza' size='340' side='right' caption='[[1zza]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
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	<table><tr><td colspan='2'>[[1zza]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zza]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZZA FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zza OCA], [http://pdbe.org/1zza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zza RCSB], [http://www.ebi.ac.uk/pdbsum/1zza PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zza OCA], [http://pdbe.org/1zza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zza RCSB], [http://www.ebi.ac.uk/pdbsum/1zza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zza ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 01:33, 11 September 2015

2015-09-11T01:33:00Z

← Older revision		Revision as of 01:33, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1zza' size='340' side='right' caption='[[1zza]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>		<StructureSection load='1zza' size='340' side='right' caption='[[1zza]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zza]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zza]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZZA FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zza RCSB], [http://www.ebi.ac.uk/pdbsum/1zza PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zza OCA], [http://pdbe.org/1zza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zza RCSB], [http://www.ebi.ac.uk/pdbsum/1zza PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 1zza" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Buck-Koehntop, B A]]		[[Category: Buck-Koehntop, B A]]
	[[Category: Buffy, J J]]		[[Category: Buffy, J J]]

OCA at 09:10, 25 December 2014

2014-12-25T09:10:58Z

← Older revision		Revision as of 09:10, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zza RCSB], [http://www.ebi.ac.uk/pdbsum/1zza PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zza RCSB], [http://www.ebi.ac.uk/pdbsum/1zza PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/SNN_HUMAN SNN_HUMAN]] Plays a role in the toxic effects of organotins.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 04:52, 22 December 2014

2014-12-22T04:52:21Z

← Older revision		Revision as of 04:52, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zza]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZZA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zza]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZZA FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zza RCSB], [http://www.ebi.ac.uk/pdbsum/1zza PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zza RCSB], [http://www.ebi.ac.uk/pdbsum/1zza PDBsum]</span></td></tr>
	<table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Buck-Koehntop, B A.]]		[[Category: Buck-Koehntop, B A]]
	[[Category: Buffy, J J.]]		[[Category: Buffy, J J]]
	[[Category: Mascioni, A.]]		[[Category: Mascioni, A]]
	[[Category: Veglia, G.]]		[[Category: Veglia, G]]
	[[Category: Helix]]		[[Category: Helix]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 06:47, 9 June 2014

2014-06-09T06:47:45Z

← Older revision		Revision as of 06:47, 9 June 2014
Line 1:		Line 1:
	[[~~Image~~:1zza.~~png\|left\|200px~~]]		==Solution NMR Structure of the Membrane Protein Stannin==
			<StructureSection load='1zza' size='340' side='right' caption='[[1zza]], [[NMR_Ensembles_of_Models \| 25 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[1zza]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZZA FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zza RCSB], [http://www.ebi.ac.uk/pdbsum/1zza PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Organotin compounds or alkyltins are ubiquitous environmental toxins that have been implicated in cellular death. Unlike other xenobiotic compounds, such as organomercurials and organoleads, alkyltins activate apoptotic cascades at low concentrations. Trimethyltin (TMT) chloride is amongst the most toxic organotin compounds, and is known to selectively inflict injury to specific regions of the brain. Stannin (SNN), an 88-residue mitochondrial membrane protein, has been identified as the specific marker for neuronal cell apoptosis induced by TMT intoxication. This high specificity of TMT makes SNN an ideal model system for understanding the mechanism of organotin neurotoxicity at a molecular level. Here, we report the three-dimensional structure and dynamics of SNN in detergent micelles, and its topological orientation in lipid bilayers as determined by solution and solid-state NMR spectroscopy. We found that SNN is a monotopic membrane protein composed of three domains: a single transmembrane helix (residues 10-33) that transverses the lipid bilayer at approximately a 20 degrees angle with respect to the membrane normal; a 28 residue unstructured linker, which includes a conserved CXC metal-binding motif and a putative 14-3-3zeta binding domain; and a distorted cytoplasmic helix (residues 61-79) that is partially absorbed into the plane of the lipid bilayer with a tilt angle of approximately 80 degrees from the membrane normal. The structure and architecture of SNN within the lipid environment provides insight about how this protein transmits toxic insults caused by TMT across the membrane.

	~~{{STRUCTURE_1zza\| PDB=1zza \| SCENE= }}~~		Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride.,Buck-Koehntop BA, Mascioni A, Buffy JJ, Veglia G J Mol Biol. 2005 Dec 2;354(3):652-65. Epub 2005 Sep 30. PMID:16246365<ref>PMID:16246365</ref>

	~~===Solution NMR Structure~~ of the ~~Membrane Protein Stannin===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16246365}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[1zza]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016246365<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Buck-Koehntop, B A.]]		[[Category: Buck-Koehntop, B A.]]

OCA: Protected "1zza" [edit=sysop:move=sysop]

2012-08-14T14:45:02Z

Protected "1zza" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:45, 14 August 2012
(No difference)

OCA at 14:45, 14 August 2012

2012-08-14T14:45:00Z

← Older revision		Revision as of 14:45, 14 August 2012
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	~~{{Seed}}~~
	[[Image:1zza.png\|left\|200px]]		[[Image:1zza.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_1zza", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_1zza\| PDB=1zza \| SCENE= }}		{{STRUCTURE_1zza\| PDB=1zza \| SCENE= }}

	===Solution NMR Structure of the Membrane Protein Stannin===		===Solution NMR Structure of the Membrane Protein Stannin===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16246365}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16246365 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16246365}}		{{ABSTRACT_PUBMED_16246365}}

	==About this Structure==		==About this Structure==
	~~1ZZA is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA].		[[1zza]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA].

	==Reference==		==Reference==
	Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride., Buck-Koehntop BA, Mascioni A, Buffy JJ, Veglia G, J Mol Biol. 2005 Dec 2;354(3):652-65. Epub 2005 Sep 30. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~16246365 16246365]~~		<ref group="xtra">PMID:016246365</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Buck-Koehntop, B A.]]		[[Category: Buck-Koehntop, B A.]]
	[[Category: Buffy, J J.]]		[[Category: Buffy, J J.]]
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	[[Category: Veglia, G.]]		[[Category: Veglia, G.]]
	[[Category: Helix]]		[[Category: Helix]]
			[[Category: Membrane protein]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Jul 28 16:39:46 2008''~~

OCA at 13:39, 28 July 2008

2008-07-28T13:39:49Z

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	[[Image:1zza.~~gif~~\|left\|200px]]		{{Seed}}
			[[Image:1zza.png\|left\|200px]]

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	{{STRUCTURE_1zza\| PDB=1zza \| SCENE= }}		{{STRUCTURE_1zza\| PDB=1zza \| SCENE= }}

	~~'''~~Solution NMR Structure of the Membrane Protein Stannin~~'''~~		===Solution NMR Structure of the Membrane Protein Stannin===


	~~==Overview==~~		<!--
	~~Organotin compounds or alkyltins are ubiquitous environmental toxins that have been implicated in cellular death. Unlike other xenobiotic compounds~~, ~~such as organomercurials and organoleads~~, ~~alkyltins activate apoptotic cascades at low concentrations. Trimethyltin (TMT) chloride is amongst~~ the ~~most toxic organotin compounds, and is known to selectively inflict injury~~ to ~~specific regions of~~ the ~~brain. Stannin~~ (~~SNN), an 88-residue mitochondrial membrane protein, has been identified~~ as ~~the specific marker for neuronal cell apoptosis induced by TMT intoxication. This high specificity of TMT makes SNN an ideal model system for understanding the mechanism of organotin neurotoxicity~~ at ~~a molecular level~~. ~~Here, we report the three-dimensional structure and dynamics of SNN in detergent micelles, and its topological orientation in lipid bilayers as determined by solution and solid-state NMR spectroscopy~~. ~~We found that SNN is a monotopic membrane protein composed of three domains: a single transmembrane helix (residues 10-33~~) ~~that transverses the lipid bilayer at approximately a 20 degrees angle with respect to the membrane normal; a 28 residue unstructured linker~~, ~~which includes a conserved CXC metal-binding motif and a putative 14-3-3zeta binding domain; and a distorted cytoplasmic helix (residues 61-79) that~~ is ~~partially absorbed into the plane of~~ the lipid bilayer with a tilt angle of approximately 80 degrees from the membrane normal. The structure and architecture of SNN within the lipid environment provides insight about how this protein transmits toxic insults caused by TMT across the membrane.		The line below this paragraph, {{ABSTRACT_PUBMED_16246365}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 16246365 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_16246365}}

	==About this Structure==		==About this Structure==
	1ZZA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA].		1ZZA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZA OCA].

	==Reference==		==Reference==
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	[[Category: Veglia, G.]]		[[Category: Veglia, G.]]
	[[Category: Helix]]		[[Category: Helix]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 18~~:16:01 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:39:46 2008''